The Tampa Bay Rays allowed their most runs in a game on June 27 and on July 23, 2002, with 22 runs.

Interpreted as:

most runs allowed by the rays in a regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Rays	22	6/27/2025	TBR	@	BAL	L 8-22	22.50	9	0	0	8.0	21	20	4	8	1	0	55	0	10.13	9.00	1.13	4.50	16.4	14.5	3.63	.515	24.75	23.63
2	Devil Rays	22	7/23/2002	TBD	@	BOS	L 4-22	19.13	4	0	0	8.0	19	17	7	7	0	0	51	1	4.50	7.88	0.57	7.88	7.8	13.7	3.25	.364	24.75	21.38
3	Devil Rays	21	7/22/2007	TBD	@	NYY	L 4-21	23.63	8	0	0	8.0	25	21	6	7	1	0	56	1	9.00	7.88	1.14	6.75	14.3	12.5	4.00	.559	23.63	28.13
4	Rays	20	5/23/2023	TBR	vs	TOR	L 1-20	19.00	9	0	0	9.0	27	19	4	1	0	0	54	2	9.00	1.00	9.00	4.00	16.7	1.9	3.11	.575	20.00	27.00
5	Rays	20	8/11/2021	TBR	@	BOS	L 8-20	22.50	6	0	0	8.0	19	20	1	9	2	2	53	0	6.75	10.13	0.67	1.13	11.3	17.0	3.50	.514	22.50	21.38
6	Devil Rays	20	6/21/2005	TBD	@	NYY	L 11-20	22.50	5	0	0	8.0	23	20	6	4	0	1	51	0	5.63	4.50	1.25	6.75	9.8	7.8	3.38	.472	22.50	25.88
7	Devil Rays	20	6/25/2002	TBD	vs	TOR	L 11-20	20.00	10	0	0	9.0	19	20	5	7	2	0	55	1	10.00	7.00	1.43	5.00	18.2	12.7	2.89	.452	20.00	19.00
8	Devil Rays	20	5/7/1999	TBD	@	CLE	L 11-20	13.50	7	0	0	8.0	21	12	5	7	1	0	53	0	7.88	7.88	1.00	5.63	13.2	13.2	3.50	.485	22.50	23.63
9	Devil Rays	19	4/18/2005	TBD	@	NYY	L 8-19	19.13	3	0	0	8.0	20	17	3	7	2	1	54	0	3.38	7.88	0.43	3.38	5.6	13.0	3.38	.436	21.38	22.50
10	Devil Rays	18	6/11/2005	TBD	@	PIT	L 2-18	13.50	8	0	0	8.0	20	12	1	4	1	0	52	0	9.00	4.50	2.00	1.13	15.4	7.7	3.00	.500	20.25	22.50
11	Devil Rays	18	5/18/2001	TBD	vs	DET	L 2-18	12.00	10	0	0	9.0	19	12	1	4	1	0	52	2	10.00	4.00	2.50	1.00	19.2	7.7	2.56	.500	18.00	19.00
12	Rays	17	7/29/2023	TBR	@	HOU	L 4-17	19.13	7	0	0	8.0	18	17	5	6	0	0	48	0	7.88	6.75	1.17	5.63	14.6	12.5	3.00	.433	19.13	20.25
13	Rays	17	5/13/2018	TBR	@	BAL	L 1-17	19.13	5	0	0	8.0	19	17	4	5	0	0	49	2	5.63	5.63	1.00	4.50	10.2	10.2	3.00	.429	19.13	21.38
14	Rays	17	8/7/2010	TBR	@	TOR	L 11-17	19.13	4	0	0	8.0	20	17	8	6	0	0	49	1	4.50	6.75	0.67	9.00	8.2	12.2	3.25	.387	19.13	22.50
15	Devil Rays	17	7/21/2007	TBD	@	NYY	L 5-17	18.00	3	0	0	8.0	20	16	2	3	0	0	47	0	3.38	3.38	1.00	2.25	6.4	6.4	2.88	.462	19.13	22.50
16	Devil Rays	17	9/13/2005	TBD	vs	NYY	L 3-17	15.00	4	0	0	9.0	20	15	1	9	0	0	55	1	4.00	9.00	0.44	1.00	7.3	16.4	3.22	.463	17.00	20.00
17	Devil Rays	17	9/15/2000	TBD	vs	OAK	L 3-17	16.00	7	0	0	9.0	20	16	3	8	0	0	54	1	7.00	8.00	0.88	3.00	13.0	14.8	3.11	.472	17.00	20.00
18	Devil Rays	17	4/9/2000	TBD	vs	CLE	L 4-17	12.00	12	0	0	9.0	16	12	3	4	1	0	50	0	12.00	4.00	3.00	3.00	24.0	8.0	2.22	.433	17.00	16.00
19	Devil Rays	17	8/10/1999	TBD	vs	BAL	L 1-17	12.00	5	0	0	9.0	20	12	0	8	2	0	58	1	5.00	8.00	0.63	0.00	8.6	13.8	3.11	.465	17.00	20.00
20	Rays	16	6/16/2015	TBR	vs	WSH	L 4-16	15.00	3	0	0	9.0	23	15	4	5	1	0	53	0	3.00	5.00	0.60	4.00	5.7	9.4	3.11	.475	16.00	23.00
21	Devil Rays	16	9/11/2007	TBD	@	BOS	L 10-16	18.00	4	0	0	8.0	20	16	4	4	0	0	47	0	4.50	4.50	1.00	4.50	8.5	8.5	3.00	.457	18.00	22.50
22	Devil Rays	16	9/25/2006	TBD	vs	NYY	L 1-16	16.00	3	0	0	9.0	20	16	4	5	1	0	51	0	3.00	5.00	0.60	4.00	5.9	9.8	2.78	.421	16.00	20.00
23	Devil Rays	16	4/5/2006	TBD	@	BAL	L 6-16	16.88	4	0	0	8.0	16	15	3	9	0	0	50	1	4.50	10.13	0.44	3.38	8.0	18.0	3.13	.382	18.00	18.00
24	Devil Rays	16	6/1/2004	TBD	@	MIN	L 4-16	16.88	6	0	0	8.0	14	15	5	8	1	0	48	3	6.75	9.00	0.75	5.63	12.5	16.7	2.75	.321	18.00	15.75
25	Devil Rays	16	8/8/2001	TBD	vs	NYY	L 1-16	14.00	10	0	0	9.0	17	14	3	8	1	0	52	0	10.00	8.00	1.25	3.00	19.2	15.4	2.78	.467	16.00	17.00