The Baltimore Orioles gave up their most runs in a game against the Rangers on August 22, 2007, with 30 runs.

Interpreted as:

most runs allowed regular-season game by orioles

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Orioles	30	8/22/2007	BAL	vs	TEX	L 3-30	30.00	11	0	0	9.0	29	30	6	8	0	0	65	1	11.00	8.00	1.38	6.00	16.9	12.3	4.11	.575	30.00	29.00
2	Browns	29	6/8/1950	SLA	@	BSA	L 4-29	29.25	2	0	0	8.0	28	26	7	11	0	0	64	0	2.25	12.38	0.18	7.88	3.1	17.2	4.88	.477	32.63	31.50
3	Orioles	26	4/19/1996	BAL	@	TEX	L 7-26	29.25	2	0	0	8.0	19	26	5	13	1	0	55	1	2.25	14.62	0.15	5.63	3.6	23.6	4.00	.412	29.25	21.38
4	Browns	26	8/12/1948	SLA	vs	CLE	L 3-26	0.00	4	0	0	9.0	29	0	4	6	0		61	2	4.00	6.00	0.67	4.00	6.6	9.8	3.89	.532	26.00	29.00
5	Orioles	24	4/20/2025	BAL	vs	CIN	L 2-24	24.00	6	0	0	9.0	25	24	3	11	2	0	64	0	6.00	11.00	0.55	3.00	9.4	17.2	4.00	.524	24.00	25.00
6	Orioles	24	6/26/1978	BAL	@	TOR	L 10-24	27.00	6	0	0	8.0	24	24	2	8	0	0	56	1	6.75	9.00	0.75	2.25	10.7	14.3	4.00	.550	27.00	27.00
7	Orioles	23	8/10/2019	BAL	vs	HOU	L 2-23	23.00	4	0	0	9.0	25	23	6	2	0	0	52	1	4.00	2.00	2.00	6.00	7.7	3.8	3.00	.475	23.00	25.00
8	Orioles	22	9/12/2021	BAL	vs	TOR	L 7-22	22.00	8	0	0	9.0	19	22	5	8	2	0	55	0	8.00	8.00	1.00	5.00	14.5	14.5	3.00	.438	22.00	19.00
9	Browns	21	6/24/1949	SLA	@	BSA	L 2-21	23.63	4	0	0	8.0	25	21	2	12	0		60	0	4.50	13.50	0.33	2.25	6.7	20.0	4.63	.548	23.63	28.13
10	Browns	21	4/14/1925	SLA	vs	CLE	L 14-21	0.00	5	0	0	9.0	19	0	4	7	0		59	1	5.00	7.00	0.71	4.00	8.5	11.9	2.89	.349	21.00	19.00
11	Browns	21	7/25/1920	SLA	@	DET	L 8-21	0.00	2	0	0	8.0	22	0	0	6	0		52	0	2.25	6.75	0.33	0.00	3.8	11.5	3.50	.500	23.63	24.75
12	Orioles	20	8/14/1955	BAL	vs	NYY	L 6-20	16.00	4	0	0	9.0	20	16	2	11	1	0	59	1	4.00	11.00	0.36	2.00	6.8	18.6	3.44	.439	20.00	20.00
13	Browns	20	6/7/1950	SLA	@	BSA	L 4-20	22.50	7	0	0	8.0	23	20	5	7	0	0	52	0	7.88	7.88	1.00	5.63	13.5	13.5	3.75	.545	22.50	25.88
14	Browns	20	8/7/1949	SLA	@	NYY	L 2-20	13.50	2	0	0	8.0	22	12	1	3	4		55	0	2.25	3.38	0.67	1.13	3.6	5.5	3.13	.467	22.50	24.75
15	Browns	20	8/1/1943	SLA	@	WSH	L 6-20	0.00	3	0	0	8.0	19	0	0	12	2		56	1	3.38	13.50	0.25	0.00	5.4	21.4	3.88	.487	22.50	21.38
16	Browns	20	8/14/1937	SLA	@	DET	L 7-20	0.00	1	0	0	8.0	22	0	6	5	1		52	0	1.13	5.63	0.20	6.75	1.9	9.6	3.38	.410	22.50	24.75
17	Browns	20	5/21/1925	SLA	vs	PHA	L 4-20	0.00	3	0	0	9.0	19	0	5	6	1		53	0	3.00	6.00	0.50	5.00	5.7	11.3	2.78	.368	20.00	19.00
18	Brewers	20	9/7/1901	MIL	vs	WSH	L 8-20	0.00	-10	0	0	7.0	15	0	0	7	1	-10	0	1	-12.86	9.00	-1.43	0.00			3.14	7.500	25.71	19.29
19	Orioles	19	5/23/2025	BAL	@	BOS	L 5-19	21.38	7	0	0	8.0	20	19	3	8	0	0	53	1	7.88	9.00	0.88	3.38	13.2	15.1	3.50	.486	21.38	22.50
20	Orioles	19	7/6/2024	BAL	@	OAK	L 8-19	21.38	6	0	0	8.0	18	19	5	6	1	0	49	0	6.75	6.75	1.00	5.63	12.2	12.2	3.00	.419	21.38	20.25
21	Orioles	19	9/26/2018	BAL	@	BOS	L 3-19	21.38	7	0	0	8.0	22	19	5	3	0	0	48	0	7.88	3.38	2.33	5.63	14.6	6.3	3.13	.515	21.38	24.75
22	Orioles	19	8/10/2018	BAL	vs	BOS	L 12-19	18.00	6	0	0	9.0	16	18	3	10	1	1	53	2	6.00	10.00	0.60	3.00	11.3	18.9	2.89	.394	19.00	16.00
23	Orioles	19	7/16/2012	BAL	@	MIN	L 7-19	14.63	3	0	0	8.0	20	13	1	5	1	0	48	0	3.38	5.63	0.60	1.13	6.3	10.4	3.13	.500	21.38	22.50
24	Orioles	19	4/15/2009	BAL	@	TEX	L 6-19	10.13	7	0	0	8.0	19	9	2	7	1	1	53	2	7.88	7.88	1.00	2.25	13.2	13.2	3.25	.472	21.38	21.38
25	Orioles	19	7/25/2000	BAL	vs	NYY	L 1-19	19.00	5	0	0	9.0	20	19	5	7	0	0	52	0	5.00	7.00	0.71	5.00	9.6	13.5	3.00	.429	19.00	20.00