The Houston Astros allowed their most runs in a game versus the Cubs on June 3, 1987, with 22 runs.

Interpreted as:

most runs astros given up in a regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Astros	22	6/3/1987	HOU	@	CHC	L 7-22	24.75	6	0	0	8.0	21	22	6	9	0	0	54	1	6.75	10.13	0.67	6.75	11.1	16.7	3.75	.455	24.75	23.63
2	Astros	21	9/10/2019	HOU	vs	OAK	L 7-21	21.00	7	0	0	9.0	25	21	6	4	0	0	56	0	7.00	4.00	1.75	6.00	12.5	7.1	3.22	.487	21.00	25.00
3	Astros	19	4/20/2013	HOU	vs	CLE	L 6-19	15.00	5	0	0	9.0	22	15	3	8	1	0	58	0	5.00	8.00	0.63	3.00	8.6	13.8	3.33	.463	19.00	22.00
4	Astros	19	9/25/2011	HOU	vs	COL	L 3-19	17.00	4	0	0	9.0	25	17	4	5	1	0	58	0	4.00	5.00	0.80	4.00	6.9	8.6	3.33	.477	19.00	25.00
5	Astros	19	6/17/1979	HOU	@	MON	L 3-19	21.38	5	0	0	8.0	24	19	5	3	1	0	48	0	5.63	3.38	1.67	5.63	10.4	6.3	3.38	.559	21.38	27.00
6	Astros	19	9/30/1965	HOU	vs	STL	L 8-19	18.00	4	0	0	9.0	19	18	1	7	0	0	54	0	4.00	7.00	0.57	1.00	7.4	13.0	2.89	.429	19.00	19.00
7	Astros	18	7/29/2007	HOU	vs	SDP	L 11-18	16.00	8	0	0	9.0	19	16	3	5	0	1	53	1	8.00	5.00	1.60	3.00	15.1	9.4	2.67	.432	18.00	19.00
8	Astros	18	5/21/2005	HOU	@	TEX	L 3-18	20.25	9	0	0	8.0	17	18	8	5	0	0	45	1	10.13	5.63	1.80	9.00	20.0	11.1	2.75	.391	20.25	19.13
9	Astros	18	7/4/2004	HOU	vs	TEX	L 3-18	18.00	9	0	0	9.0	16	18	6	8	0	2	51	1	9.00	8.00	1.13	6.00	17.6	15.7	2.67	.357	18.00	16.00
10	Astros	18	8/3/1989	HOU	@	CIN	L 2-18	20.25	3	0	0	8.0	26	18	3	1	0	0	51	3	3.38	1.13	3.00	3.38	5.9	2.0	3.38	.523	20.25	29.25
11	Astros	17	8/24/2023	HOU	vs	BOS	L 1-17	17.00	7	0	0	9.0	25	17	3	6	2	0	58	0	7.00	6.00	1.17	3.00	12.1	10.3	3.44	.550	17.00	25.00
12	Astros	17	5/4/2013	HOU	vs	DET	L 2-17	16.00	4	0	0	9.0	21	16	3	5	0	0	53	0	4.00	5.00	0.80	3.00	7.5	9.4	2.89	.439	17.00	21.00
13	Astros	17	8/30/1999	HOU	vs	NYM	L 1-17	17.00	7	0	0	9.0	21	17	5	5	0	0	51	0	7.00	5.00	1.40	5.00	13.7	9.8	2.89	.471	17.00	21.00
14	Astros	17	4/7/1996	HOU	vs	SDP	L 2-17	7.00	8	0	0	9.0	17	7	3	6	1	0	54	0	8.00	6.00	1.33	3.00	14.8	11.1	2.56	.389	17.00	17.00
15	Astros	17	5/21/1989	HOU	vs	PIT	L 5-17	9.00	4	0	0	9.0	18	9	2	3	1	0	52	0	4.00	3.00	1.33	2.00	7.7	5.8	2.33	.381	17.00	18.00
16	Astros	17	5/6/1979	HOU	@	CIN	L 5-17	13.50	6	0	0	8.0	17	12	3	5	0	0	47	0	6.75	5.63	1.20	3.38	12.8	10.6	2.75	.424	19.13	19.13
17	Astros	17	4/29/1968	HOU	vs	CIN	L 2-17	16.00	5	0	0	9.0	22	16	2	2	0	0	53	0	5.00	2.00	2.50	2.00	9.4	3.8	2.67	.455	17.00	22.00
18	Astros	16	4/6/2016	HOU	@	NYY	L 6-16	16.88	7	0	0	8.0	17	15	3	7	0	0	49	0	7.88	7.88	1.00	3.38	14.3	14.3	3.00	.438	18.00	19.13
19	Astros	16	8/19/2013	HOU	@	TEX	L 5-16	11.25	3	0	0	8.0	14	10	1	5	0	2	45	0	3.38	5.63	0.60	1.13	6.7	11.1	2.38	.361	18.00	15.75
20	Astros	16	5/16/2008	HOU	@	TEX	L 8-16	10.13	3	0	0	8.0	17	9	6	7	0	1	51	0	3.38	7.88	0.43	6.75	5.9	13.7	3.00	.314	18.00	19.13
21	Astros	16	5/8/2005	HOU	@	ATL	L 0-16	18.00	9	0	0	8.0	17	16	5	2	0	0	43	0	10.13	2.25	4.50	5.63	20.9	4.7	2.38	.444	18.00	19.13
22	Astros	16	6/9/2001	HOU	@	TEX	L 4-16	18.00	1	0	0	8.0	17	16	5	5	0	0	45	0	1.13	5.63	0.20	5.63	2.2	11.1	2.75	.353	18.00	19.13
23	Astros	16	9/20/1992	HOU	@	ATL	L 1-16	18.00	4	0	0	8.0	15	16	4	5	0	1	42	1	4.50	5.63	0.80	4.50	9.5	11.9	2.50	.379	18.00	16.88
24	Astros	16	4/13/1991	HOU	vs	SFG	L 2-16	14.00	6	0	0	9.0	19	14	2	5	0	1	49	1	6.00	5.00	1.20	2.00	12.2	10.2	2.67	.472	16.00	19.00
25	Astros	16	7/27/1985	HOU	@	NYM	L 4-16	0.00	4	0	0	8.0	15	0	1	3	0	0	45	1	4.50	3.38	1.33	1.13	8.9	6.7	2.25	.378	18.00	16.88