The New York Yankees scored the most runs by a team in a game in 1927, with 21 runs against the Washington Senators on July 4, 1927.

Interpreted as:

most runs by a team in a regular-season game in 1927

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Yankees	21	7/4/1927	NYY	vs	WSH	W 21-1	41	19	5	3	3	20	11	0	2	0	0	54	39	11	2	.463	.577	.951	1.528
2	Robins	20	5/22/1927	BKN	vs	PHN	W 20-4	43	22	1	1	0	16	4	0	5	2	0	51	25	2	4	.512	.553	.581	1.135
3	Yankees	19	7/9/1927	NYY	@	DET	W 19-7	44	20	4	0	4	19	8	1	5	2	1	54	36	8	1	.455	.547	.818	1.365
4	Yankees	18	5/31/1927	NYY	@	PHA	W 18-5	48	24	4	2	3	18	1	2	3	0	1	53	41	9	2	.500	.529	.854	1.384
5	Senators	17	8/5/1927	WSH	vs	SLA	W 17-8	42	17	4	1	1	14	6	0	1	0	0	50	26	6	2	.405	.479	.619	1.098
6	Browns	17	7/5/1927	SLA	vs	DET	W 17-8	44	20	3	1	4	13	6	0	2	4	0	52	37	8	2	.455	.520	.841	1.361
7	Tigers	17	5/9/1927	DET	vs	BSA	W 17-11	41	22	2	3	3	17	6	0	2	1	1	49	39	8	2	.537	.596	.951	1.547
8	Reds	16	9/11/1927	CIN	vs	BSN	W 16-5	41	18	4	1	1	15	4	0	2	1	0	45	27	6	0	.439	.489	.659	1.147
9	Senators	16	5/7/1927	WSH	@	SLA	W 16-9	34	9	2	0	0	10	10	1	5	2	1	47	11	2	2	.265	.444	.324	.768
10	Cubs	16	4/28/1927	CHC	@	PIT	W 16-4	40	17	2	1	1	14	8	0	5	2	0	52	24	4	4	.425	.521	.600	1.121
11	Yankees	15	9/29/1927	NYY	vs	WSH	W 15-4	38	19	3	2	2	14	5	0	3	1	0	45	32	7	2	.500	.558	.842	1.400
12	Athletics	15	9/13/1927	PHA	vs	CWS	W 15-5	37	19	6	2	0	15	7	1	1	1	3	46	29	8	1	.514	.600	.784	1.384
13	Yankees	15	7/26/1927	NYY	vs	SLA	W 15-1	37	14	0	0	2	11	7	0	2	1	0	46	20	2	2	.378	.477	.541	1.018
14	Yankees	15	5/29/1927	NYY	vs	BSA	W 15-7	39	17	3	0	1	13	8	1	1	0	0	49	23	4	1	.436	.542	.590	1.131
15	Phillies	15	5/20/1927	PHN	vs	CIN	W 15-2	38	15	0	0	3	13	4	0	4	1	0	44	24	3	2	.395	.452	.632	1.084
16	Athletics	15	4/28/1927	PHA	vs	WSH	W 15-7	37	15	3	0	0	14	10	0	0	2	1	49	18	3	2	.405	.532	.486	1.018
17	Browns	15	4/23/1927	SLA	@	DET	W 15-10	43	15	6	1	0	15	5	1	4	4	1	50	23	7	1	.349	.429	.535	.963
18	Giants	15	4/12/1927	NYG	@	PHN	W 15-7	42	17	5	1	3	15	4	1	0	1	0	48	33	9	1	.405	.468	.786	1.254
19	Braves	14	10/1/1927	BSN	vs	PHN	W 14-9	39	18	2	2	0	14	3	0	1	2	0	44	24	4	2	.462	.500	.615	1.115
20	Yankees	14	9/6/1927	NYY	@	BSA	W 14-2	44	20	7	0	3	14	4	0	5	2	1	50	36	10	2	.455	.500	.818	1.318
21	Senators	14	9/6/1927	WSH	@	PHA	W 14-9	42	16	0	3	2	13	5	0	7	3	0	50	28	5	3	.381	.447	.667	1.113
22	Pirates	14	9/3/1927	PIT	vs	SLN	W 14-0	40	18	2	1	0	14	5	1	5	0	0	46	22	3	0	.450	.522	.550	1.072
23	Yankees	14	8/27/1927	NYY	@	SLA	W 14-4	39	15	3	1	3	14	9	0	1	1	1	49	29	7	1	.385	.500	.744	1.244
24	Indians	14	8/20/1927	CLE	vs	NYY	W 14-8	38	19	5	1	0	12	2	0	1	0	1	45	26	6	5	.500	.525	.684	1.209
25	Tigers	14	8/19/1927	DET	vs	BSA	W 14-7	30	12	6	1	1	12	9	0	1	3	0	41	23	8	2	.400	.538	.767	1.305