The Milwaukee Brewers had the highest run differential by a team in wins this season, with a differential of 392 runs.

Interpreted as:

most runs differential in wins this regular season

	TEAM	DIFF	W	SEASON	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Brewers	392	97	2025	0	1.000	97	3,332	653	967	189	11	123	608	376	47	692	118	33	3,820	1,547	323	22	43	14	63	.290	.366	.464	.830
2	Yankees	389	94	2025	0	1.000	94	3,221	646	913	181	12	192	626	430	41	804	98	28	3,739	1,694	385	4	43	34	54	.283	.371	.526	.896
3	Cubs	384	92	2025	0	1.000	92	3,201	611	919	177	25	167	596	348	31	678	120	18	3,632	1,647	369	7	45	13	37	.287	.358	.515	.873
4	Tigers	355	87	2025	0	1.000	87	2,980	548	848	150	21	138	522	296	44	719	36	12	3,356	1,454	309	4	32	7	53	.285	.354	.488	.842
5	Phillies	355	96	2025	0	1.000	96	3,290	604	951	189	16	160	585	358	42	750	90	18	3,741	1,652	365	14	37	13	53	.289	.362	.502	.865
6	Dodgers	353	93	2025	0	1.000	93	3,192	622	895	171	16	168	597	359	37	743	52	17	3,636	1,602	355	6	42	25	53	.280	.356	.502	.858
7	Blue Jays	352	94	2025	0	1.000	94	3,295	636	1,012	197	10	143	612	315	45	575	55	15	3,715	1,658	350	27	33	19	72	.307	.372	.503	.875
8	Red Sox	344	89	2025	0	1.000	89	3,095	589	888	218	16	139	563	314	42	690	85	22	3,487	1,555	373	9	27	11	54	.287	.358	.502	.860
9	Rangers	319	81	2025	0	1.000	81	2,749	496	752	153	8	122	478	296	31	605	70	13	3,109	1,287	283	5	28	11	46	.274	.348	.468	.816
10	Mariners	316	90	2025	0	1.000	90	3,090	562	837	155	5	168	540	339	52	753	99	20	3,528	1,506	328	19	28	24	54	.271	.350	.487	.837
11	Athletics	311	76	2025	0	1.000	76	2,686	490	783	163	9	140	472	242	26	641	48	21	2,991	1,384	312	14	23	9	41	.292	.353	.515	.868
12	Mets	307	83	2025	0	1.000	83	2,850	543	826	169	14	153	531	294	51	631	87	11	3,236	1,482	336	10	31	17	62	.290	.363	.520	.883
13	Padres	307	90	2025	0	1.000	90	3,053	514	863	158	10	107	486	334	33	614	70	16	3,481	1,362	275	34	27	12	52	.283	.357	.446	.803
14	Astros	306	87	2025	0	1.000	87	3,005	519	857	152	9	136	495	285	44	647	55	23	3,370	1,435	297	12	24	12	61	.285	.353	.478	.831
15	Reds	296	83	2025	0	1.000	83	2,795	494	779	142	11	112	468	300	32	678	60	16	3,165	1,279	265	7	31	12	54	.279	.352	.458	.809
16	Rays	286	77	2025	0	1.000	77	2,676	502	787	148	11	118	474	236	25	639	113	23	2,974	1,311	277	9	28	5	42	.294	.353	.490	.843
17	Braves	282	76	2025	0	1.000	76	2,636	495	754	134	9	117	478	319	26	581	48	12	3,018	1,257	260	12	25	10	52	.286	.366	.477	.842
18	Diamondbacks	272	80	2025	0	1.000	80	2,691	496	754	156	20	129	486	303	42	618	75	23	3,105	1,337	305	30	39	10	50	.280	.357	.497	.854
19	Orioles	270	75	2025	0	1.000	75	2,544	447	698	139	13	116	425	258	39	630	64	21	2,871	1,211	268	3	27	12	48	.274	.347	.476	.823
20	Royals	269	82	2025	0	1.000	82	2,806	474	804	184	9	115	466	242	37	511	78	24	3,131	1,351	308	20	26	12	47	.287	.348	.481	.830
21	Giants	268	81	2025	0	1.000	81	2,725	492	720	135	21	117	469	308	32	666	39	16	3,114	1,248	273	13	36	10	42	.264	.342	.458	.800
22	Twins	262	70	2025	0	1.000	70	2,396	434	678	129	11	111	414	258	50	548	56	20	2,728	1,162	251	5	19	7	40	.283	.362	.485	.847
23	Guardians	256	88	2025	0	1.000	88	2,921	470	746	163	14	107	452	293	38	703	90	17	3,311	1,258	284	22	37	21	40	.255	.327	.431	.758
24	Cardinals	255	78	2025	0	1.000	78	2,623	466	736	154	5	97	442	262	40	598	55	19	2,971	1,191	256	16	30	13	44	.281	.351	.454	.805
25	Pirates	238	71	2025	0	1.000	71	2,385	368	659	133	11	66	354	255	29	585	52	20	2,698	1,012	210	5	24	13	62	.276	.350	.424	.774