Antonio Senzatela has allowed the most runs this season, with 52 runs.

Interpreted as:

most runs given up by a player in 1 inning this regular season

	NAME	R	SEASON	TM	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Antonio Senzatela A. Senzatela	52	2025	COL	13	1	10	.091	12	6.68	33	0	0	0	62.0	101	46	11	21	1	0	0	300	3	4.79	3.05	1.57	1.60	11.0	7.0	1.97	.385	7.55	146	5.37	130	14.66	-7.9
2	Sandy Alcantara S. Alcantara	51	2025	MIA	12	2	7	.222	12	7.89	44	0	0	0	57.0	60	50	8	30	2	0	0	261	4	6.95	4.74	1.47	1.26	16.9	11.5	1.58	.294	8.05	192	5.03	127	9.47	-6.9
3	Kyle Freeland K. Freeland	51	2025	COL	13	1	8	.111	13	5.19	52	0	0	0	67.2	91	39	7	13	2	0	1	303	1	6.92	1.73	4.00	0.93	17.2	4.3	1.54	.367	6.78	114	3.53	85	12.10	4.5
4	Germán Márquez G. Márquez	51	2025	COL	12	2	7	.222	12	6.98	38	0	0	0	58.0	77	45	4	21	4	0	0	271	4	5.90	3.26	1.81	0.62	14.0	7.7	1.69	.358	7.91	153	3.94	95	11.95	1.3
5	Zac Gallen Z. Gallen	45	2025	AZ	13	4	7	.364	13	5.13	70	0	0	0	73.2	65	42	11	33	2	0	1	319	1	8.55	4.03	2.12	1.34	21.9	10.3	1.33	.266	5.50	126	4.53	118	7.94	-6
6	Jeffrey Springs J. Springs	43	2025	ATH	13	5	4	.556	12	4.66	56	0	0	0	67.2	60	35	11	31	0	0	0	295	0	7.45	4.12	1.81	1.46	19.0	10.5	1.34	.249	5.72	118	4.89	121	7.98	-6.3
7	Brandon Pfaadt B. Pfaadt	43	2025	AZ	13	7	4	.636	13	5.51	51	0	0	0	65.1	72	40	12	17	6	0	1	286	2	7.03	2.34	3.00	1.65	17.8	5.9	1.36	.300	5.92	135	4.94	129	9.92	-8.5
8	Dean Kremer D. Kremer	42	2025	BAL	13	5	6	.455	13	4.98	53	0	0	0	72.1	83	40	10	19	1	0	0	315	5	6.59	2.36	2.79	1.24	16.8	6.0	1.41	.315	5.23	128	4.22	106	10.33	-2.1
9	Tanner Houck T. Houck	41	2025	BOS	9	0	3	.000	9	8.04	32	0	0	0	43.2	57	39	10	17	5	0	0	203	2	6.60	3.50	1.88	2.06	15.8	8.4	1.69	.338	8.45	192	6.08	149	11.75	-9.6
10	Eduardo Rodriguez E. Rodriguez	41	2025	AZ	9	1	3	.250	9	7.05	52	0	0	0	44.2	58	35	8	18	0	0	0	211	2	10.48	3.63	2.89	1.61	24.6	8.5	1.70	.376	8.26	173	4.27	112	11.69	-2.3
11	Luis Severino L. Severino	41	2025	ATH	13	1	5	.167	13	4.54	55	0	0	0	77.1	75	39	4	23	5	0	1	333	1	6.40	2.68	2.39	0.47	16.5	6.9	1.27	.289	4.77	115	3.40	84	8.73	5.6
12	Trevor Williams T. Williams	41	2025	WSH	12	3	6	.333	12	6.03	47	0	0	0	59.2	70	40	7	16	2	0	0	264	1	7.09	2.41	2.94	1.06	17.8	6.1	1.44	.328	6.18	151	3.92	98	10.56	0.5
13	Bowden Francis B. Francis	40	2025	TOR	12	2	7	.222	12	5.84	48	0	0	0	57.0	65	37	17	19	4	0	0	252	3	7.58	3.00	2.53	2.68	19.0	7.5	1.47	.293	6.32	149	6.47	160	10.26	-15.3
14	Kyle Hendricks K. Hendricks	39	2025	LAA	12	3	6	.333	12	5.40	41	0	0	0	65.0	66	39	11	20	4	0	3	278	0	5.68	2.77	2.05	1.52	14.7	7.2	1.32	.272	5.40	134	5.11	122	9.14	-6.5
15	Michael Lorenzen M. Lorenzen	39	2025	KCR	12	3	6	.333	12	5.12	54	0	0	0	65.0	75	37	12	20	2	0	0	288	9	7.48	2.77	2.70	1.66	18.8	6.9	1.46	.315	5.40	123	4.82	119	10.38	-5.5
16	Charlie Morton C. Morton	39	2025	BAL	14	2	7	.222	8	6.20	52	0	0	0	53.2	58	37	10	27	3	1	0	247	1	8.72	4.53	1.93	1.68	21.1	10.9	1.58	.310	6.54	160	5.22	132	9.73	-7.7
17	Jesús Luzardo J. Luzardo	39	2025	PHI	13	5	2	.714	13	4.46	83	0	0	0	72.2	81	36	6	24	1	0	0	314	1	10.28	2.97	3.46	0.74	26.4	7.6	1.44	.375	4.83	110	2.88	72	10.03	9.1
18	JP Sears	39	2025	ATH	13	5	5	.500	13	5.21	49	0	0	0	67.1	73	39	15	14	4	0	0	290	1	6.55	1.87	3.50	2.00	16.9	4.8	1.29	.279	5.21	132	5.30	131	9.76	-9.4
19	Ben Brown B. Brown	39	2025	CHC	13	3	4	.429	11	5.37	78	0	0	0	63.2	71	38	7	20	3	0	0	282	1	11.03	2.83	3.90	0.99	27.7	7.1	1.43	.368	5.51	137	3.12	81	10.04	5.3
20	Max Meyer M. Meyer	39	2025	MIA	12	3	5	.375	12	4.73	68	0	0	0	64.2	72	34	12	20	2	0	0	285	0	9.46	2.78	3.40	1.67	23.9	7.0	1.42	.328	5.43	115	4.39	111	10.02	-3.2
21	Jack Kochanowicz J. Kochanowicz	39	2025	LAA	12	3	7	.300	12	5.34	44	0	0	0	64.0	68	38	10	32	5	0	2	283	3	6.19	4.50	1.38	1.41	15.5	11.3	1.56	.302	5.48	132	5.45	131	9.56	-8.8
22	Dylan Cease D. Cease	38	2025	SDP	13	1	5	.167	13	4.72	85	0	0	0	68.2	66	36	8	24	1	0	1	292	2	11.14	3.15	3.54	1.05	29.1	8.2	1.31	.333	4.98	122	3.19	82	8.65	5.5
23	Mitch Keller M. Keller	38	2025	PIT	13	1	8	.111	13	4.13	61	0	0	0	76.1	77	35	5	20	4	0	0	324	1	7.19	2.36	3.05	0.59	18.8	6.2	1.27	.308	4.48	100	3.26	83	9.08	5.8
24	Andre Pallante A. Pallante	37	2025	STL	12	4	3	.571	12	4.91	44	0	0	0	66.0	68	36	11	23	0	0	0	284	4	6.00	3.14	1.91	1.50	15.5	8.1	1.38	.277	5.05	124	4.94	128	9.27	-8.1
25	Jordan Hicks J. Hicks	36	2025	SFG	13	1	5	.167	9	6.47	43	0	0	0	48.2	55	35	3	20	4	2	0	217	4	7.95	3.70	2.15	0.55	19.8	9.2	1.54	.354	6.66	165	3.58	94	10.17	1.1