Trevor Story put up the most runs in a game in 2022, with 5 runs against the Mariners on May 19, 2022.

Interpreted as:

most runs in a regular-season game by a player in 2022

	NAME	R	DATE	TM		OPP	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Trevor Story T. Story	5	5/19/2022	BOS	vs	SEA	4	4	0	0	3	7	1	0	0	1	0	5	13	3	0	0	0	0
2	Joey Meneses J. Meneses	4	10/1/2022	WSH	vs	PHI	4	3	1	0	1	4	1	0	0	0	0	5	7	2	0	0	0	0
3	Teoscar Hernández T. Hernández	4	10/1/2022	TOR	vs	BOS	5	4	2	0	1	2	0	0	0	0	0	5	9	3	0	0	0	1
4	Jose Altuve J. Altuve	4	9/27/2022	HOU	vs	ARI	4	3	1	0	2	2	1	0	0	0	0	5	10	3	0	0	0	0
5	Gleyber Torres G. Torres	4	9/21/2022	NYY	vs	PIT	4	3	0	0	2	5	1	0	0	0	0	5	9	2	0	0	0	0
6	Enrique Hernández E. Hernández	4	9/18/2022	BOS	vs	KCR	3	2	1	0	0	1	2	0	0	0	0	5	3	1	0	0	0	0
7	Martín Maldonado M. Maldonado	4	9/18/2022	HOU	vs	OAK	4	4	0	0	1	4	0	0	0	0	0	4	7	1	0	0	0	0
8	MJ Melendez	4	9/17/2022	KCR	@	BOS	5	3	1	0	0	2	0	0	0	1	0	5	4	1	0	0	0	0
9	Tony Kemp T. Kemp	4	9/11/2022	OAK	vs	CWS	4	3	0	1	1	3	0	1	0	0	0	5	8	2	0	0	0	0
10	Bo Bichette B. Bichette	4	9/6/2022	TOR	@	BAL	5	4	1	0	1	2	0	0	0	0	0	5	8	2	0	0	0	0
11	Josh Donaldson J. Donaldson	4	8/25/2022	NYY	@	OAK	5	3	2	0	0	3	1	0	1	0	0	6	5	2	0	0	0	0
12	Jake Fraley J. Fraley	4	8/21/2022	CIN	@	PIT	2	2	0	0	1	3	3	0	0	1	0	5	5	1	0	0	0	0
13	Alex Bregman A. Bregman	4	8/18/2022	HOU	@	CWS	6	4	2	0	2	6	0	0	1	1	0	6	12	4	0	0	0	0
14	Teoscar Hernández T. Hernández	4	7/22/2022	TOR	@	BOS	4	3	0	0	1	2	1	0	1	0	0	5	6	1	0	0	0	0
15	Danny Jansen D. Jansen	4	7/22/2022	TOR	@	BOS	6	3	0	0	2	6	1	0	1	0	0	7	9	2	0	0	0	0
16	Santiago Espinal S. Espinal	4	7/22/2022	TOR	@	BOS	6	2	0	0	0	1	1	0	0	0	0	7	2	0	0	0	0	0
17	Amed Rosario A. Rosario	4	6/15/2022	CLE	@	COL	5	3	0	1	1	1	0	0	0	1	0	5	8	2	0	0	0	0
18	Brendan Rodgers B. Rodgers	4	6/1/2022	COL	vs	MIA	5	3	0	0	3	4	1	0	1	0	0	6	12	3	0	0	0	0
19	Ryan Mountcastle R. Mountcastle	4	5/30/2022	BAL	@	BOS	5	4	1	0	1	1	0	0	0	0	0	5	8	2	0	0	0	1
20	Alejandro Kirk A. Kirk	4	5/29/2022	TOR	@	LAA	4	2	1	0	0	1	1	0	0	0	0	5	3	1	0	0	0	0
21	Alex Verdugo A. Verdugo	4	5/19/2022	BOS	vs	SEA	5	3	1	0	0	0	0	0	0	0	0	5	4	1	0	0	0	0
22	Luis Arraez L. Arraez	4	5/18/2022	MIN	@	OAK	5	3	2	0	0	2	1	0	0	1	0	6	5	2	0	0	0	0
23	Hunter Dozier H. Dozier	4	5/13/2022	KCR	@	COL	5	5	1	0	0	1	0	0	0	0	0	5	6	1	0	0	0	0
24	Whit Merrifield W. Merrifield	4	5/11/2022	KCR	@	TEX	4	4	0	0	1	1	0	0	0	1	0	4	7	1	0	0	0	0
25	Mauricio Dubón M. Dubón	4	5/7/2022	SFG	vs	STL	4	2	0	0	1	2	1	0	0	0	0	5	5	1	0	0	0	0