The Cleveland Indians had their most runs in a game against the Red Sox on July 7, 1923, with 27 runs.

Interpreted as:

most runs in a regular-season game by guardians

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Indians	27	7/7/1923	CLE	vs	BSA	W 27-3	43	24	5	2	0	25	14	1	1	4	2	61	33	7	3				.558	.672	.767	1.440
2	Indians	26	8/12/1948	CLE	@	SLA	W 26-3	55	29	5	1	4	24	6	0	4	4	0	61	48	10	0			2	.527	.574	.873	1.446
3	Indians	25	5/11/1930	CLE	vs	PHA	W 25-7	47	25	9	0	0	24	7	0	2	1	0	57	34	9	3				.532	.593	.723	1.316
4	Indians	24	7/29/1928	CLE	vs	NYY	W 24-6	52	27	2	1	0	24	4	0	5	2	0	58	31	3	2				.519	.554	.596	1.150
5	Bronchos	23	9/2/1902	CLE	vs	BAL	W 23-7	52	23	6	1	1	18	3	0	-8	3	-11	56	34	8	1		-11	-11	.442	.473	.654	1.127
6	Indians	22	4/18/2009	CLE	@	NYY	W 22-4	52	25	7	0	6	22	6	0	10	0	0	58	50	13	0	0	0	0	.481	.534	.962	1.496
7	Indians	22	8/31/2004	CLE	@	NYY	W 22-0	49	22	5	1	3	22	9	0	6	1	0	59	38	9	0	1	0	0	.449	.525	.776	1.301
8	Indians	22	8/7/1923	CLE	@	WSH	W 22-2	46	26	3	4	0	19	8	0	2	0	1	56	37	7	2				.565	.630	.804	1.434
9	Indians	21	4/29/1952	CLE	@	PHA	W 21-9	51	25	3	0	4	20	7	0	4	0	1	58	40	7	0		0	2	.490	.552	.784	1.336
10	Indians	21	6/18/1950	CLE	vs	PHA	W 21-2	37	14	1	0	2	18	16	0	4	0	0	53	21	3	0		0	2	.378	.566	.568	1.134
11	Indians	21	4/14/1925	CLE	@	SLA	W 21-14	49	19	2	0	4	19	7	0	5	5	1	59	33	6	3				.388	.464	.673	1.138
12	Indians	20	5/7/1999	CLE	vs	TBD	W 20-11	44	21	2	1	5	19	7	1	7	0	1	52	40	8	0	0	0	1	.477	.558	.909	1.467
13	Indians	20	5/4/1991	CLE	@	OAK	W 20-6	46	20	3	1	3	20	6	0	4	0	0	54	34	7	2	0	0	1	.435	.500	.739	1.239
14	Indians	20	7/22/1917	CLE	vs	PHA	W 20-6	38	17	2	0	1	20	5	0	1	3		48	22	3	5				.447	.512	.579	1.091
15	Indians	19	8/15/2019	CLE	@	NYY	W 19-5	49	24	4	0	7	19	4	1	8	0	0	54	49	11	0	0	0	1	.490	.537	1.000	1.537
16	Indians	19	7/11/2018	CLE	vs	CIN	W 19-4	42	19	1	0	4	19	7	0	6	0	0	49	32	5	0	0	0	2	.452	.531	.762	1.293
17	Indians	19	6/28/2013	CLE	@	CWS	W 19-10	47	21	8	1	1	18	9	1	11	2	0	57	34	10	0	0	0	1	.447	.544	.723	1.267
18	Indians	19	4/20/2013	CLE	@	HOU	W 19-6	49	22	7	0	3	18	8	1	5	0	0	58	38	10	0	0	0	1	.449	.534	.776	1.310
19	Indians	19	5/16/2011	CLE	@	KCR	W 19-1	44	20	7	0	1	19	8	0	5	3	0	53	30	8	1	0	0	1	.455	.538	.682	1.220
20	Indians	19	7/4/2006	CLE	vs	NYY	W 19-1	44	21	6	0	6	19	6	1	6	0	0	52	45	12	1	0	0	0	.477	.549	1.023	1.572
21	Indians	19	7/13/1996	CLE	@	MIN	W 19-11	48	22	12	0	3	19	5	1	7	2	0	54	43	15	0	0	0	0	.458	.519	.896	1.414
22	Indians	19	4/10/1977	CLE	@	BOS	W 19-9	43	19	6	1	1	15	5	0	6	1	3	51	30	8	2	1	1	0	.442	.490	.698	1.187
23	Indians	19	5/18/1955	CLE	@	BOS	W 19-0	44	19	2	1	3	18	9	1	5	0	0	56	32	6	1	1	1	0	.432	.527	.727	1.255
24	Indians	19	6/13/1936	CLE	@	PHA	W 19-1	42	17	4	1	2	15	10	0	4	0	1	52	29	7	0				.405	.519	.690	1.210
25	Indians	18	7/16/2004	CLE	@	SEA	W 18-6	46	21	5	0	8	18	5	3	5	0	0	55	50	13	1	0	0	0	.457	.537	1.087	1.624