The Baltimore Orioles had their most runs in a game versus the Blue Jays on September 28, 2000, with 23 runs.

Interpreted as:

most runs in a regular-season game by orioles

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	23	9/28/2000	BAL	vs	TOR	W 23-1	47	23	2	0	3	20	5	1	5	0	0	54	34	5	0	1	0	1	.489	.537	.723	1.260
2	Orioles	22	6/27/2025	BAL	vs	TBR	W 22-8	46	21	9	1	4	20	8	1	9	2	0	55	44	14	0	0	0	0	.457	.545	.957	1.502
3	Orioles	22	6/13/1999	BAL	@	ATL	W 22-1	51	25	7	0	4	22	6	0	8	0	0	57	44	11	0	0	0	0	.490	.544	.863	1.407
4	Brewers	21	5/5/1901	MIL	vs	CWS	W 21-7	53	25	6	1	1	18	2	0	-10	2	-10	57	36	8	2		-10	-10	.472	.491	.679	1.170
5	Browns	20	8/18/1951	SLA	vs	DET	W 20-9	42	18	1	0	1	15	11	1	3	0	0	55	22	2	1		0	1	.429	.556	.524	1.079
6	Orioles	19	6/16/2015	BAL	vs	PHI	W 19-3	39	17	2	0	8	17	8	1	7	0	0	49	43	10	0	1	0	2	.436	.531	1.103	1.633
7	Orioles	19	8/28/1957	BAL	@	CLE	W 19-6	46	19	7	1	3	18	7	0	8	1	0	54	37	11	1	0	1	1	.413	.491	.804	1.295
8	Browns	19	5/11/1925	SLA	vs	NYY	W 19-10	38	17	4	0	1	15	14	0	1	2	1	53	24	5	1				.447	.596	.632	1.228
9	Brewers	19	8/5/1901	MIL	vs	DET	W 19-4	45	17	3	1	2	12	1	1	-9	6	-10	50	28	6	3		-10	-10	.378	.404	.622	1.026
10	Orioles	18	6/6/2021	BAL	vs	CLE	W 18-5	43	21	3	0	2	16	3	1	6	0	0	47	30	5	0	0	0	2	.488	.532	.698	1.230
11	Orioles	18	8/16/2015	BAL	vs	OAK	W 18-2	48	26	7	0	4	18	3	0	8	0	0	51	45	11	0	0	0	1	.542	.569	.938	1.506
12	Orioles	18	4/26/2015	BAL	vs	BOS	W 18-7	44	20	4	1	1	17	4	0	5	0	0	49	29	6	0	1	0	0	.455	.490	.659	1.149
13	Orioles	18	4/19/2006	BAL	vs	CLE	W 18-9	46	21	4	0	3	17	1	0	3	2	0	47	34	7	0	0	0	1	.457	.468	.739	1.207
14	Orioles	18	8/15/1996	BAL	@	OAK	W 18-5	46	19	1	0	5	18	7	0	8	0	0	53	35	6	0	0	0	0	.413	.491	.761	1.251
15	Orioles	18	6/8/1986	BAL	@	NYY	W 18-9	46	22	2	0	4	17	8	0	4	0	2	55	36	6	1	0	0	1	.478	.556	.783	1.338
16	Orioles	18	9/28/1973	BAL	vs	CLE	W 18-4	34	14	3	0	1	17	15	0	5	3	1	50	20	4	0	1	1	2	.412	.580	.588	1.168
17	Orioles	18	4/29/1970	BAL	@	CWS	W 18-2	48	20	2	0	5	17	7	0	5	0	0	55	37	7	0	0	0	0	.417	.491	.771	1.262
18	Orioles	18	4/22/1965	BAL	@	WSH	W 18-4	47	20	1	1	3	17	4	1	4	2	1	52	32	5	0	0	0	0	.426	.481	.681	1.162
19	Browns	18	6/3/1944	SLA	vs	PHA	W 18-8	43	17	8	0	2	18	3	0	1	2	0	46	31	10	0			0	.395	.435	.721	1.156
20	Browns	18	7/2/1925	SLA	vs	CWS	W 18-5	38	15	4	0	3	15	7	0	2	0	0	45	28	7	0				.395	.489	.737	1.226
21	Browns	18	9/15/1920	SLA	vs	BSA	W 18-5	43	22	6	0	1	17	5	0	1	3	0	51	31	7	3				.512	.563	.721	1.283
22	Orioles	17	6/20/2024	BAL	@	NYY	W 17-5	48	20	7	0	3	17	7	2	7	1	0	58	36	10	0	1	0	0	.417	.500	.750	1.250
23	Orioles	17	5/13/2018	BAL	vs	TBR	W 17-1	44	19	3	1	4	17	5	0	5	0	0	49	36	8	0	0	0	0	.432	.490	.818	1.308
24	Orioles	17	9/27/2005	BAL	vs	NYY	W 17-9	37	14	4	0	3	16	9	1	5	1	0	48	27	7	0	1	0	0	.378	.500	.730	1.230
25	Orioles	17	8/10/1999	BAL	@	TBD	W 17-1	47	20	6	1	0	15	8	2	5	0	0	58	28	7	0	1	0	2	.426	.517	.596	1.113