The Toronto Blue Jays had their most runs in a game versus the Red Sox on July 22, 2022, with 28 runs.

Interpreted as:

most runs in a regular-season game by the blue jays

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Blue Jays	28	7/22/2022	TOR	@	BOS	W 28-5	57	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
2	Blue Jays	24	6/26/1978	TOR	vs	BAL	W 24-10	47	24	7	2	2	24	8	0	6	0	0	56	41	11	0	1	0	0	.511	.571	.872	1.444
3	Blue Jays	22	9/12/2021	TOR	@	BAL	W 22-7	45	19	5	0	5	22	8	2	8	0	0	55	39	10	0	0	0	0	.422	.527	.867	1.394
4	Blue Jays	20	5/23/2023	TOR	@	TBR	W 20-1	52	27	3	1	4	18	1	0	9	2	0	54	44	8	0	1	0	1	.519	.519	.846	1.365
5	Blue Jays	20	6/25/2002	TOR	@	TBD	W 20-11	45	19	3	0	5	20	7	2	10	0	0	55	37	8	0	1	0	0	.422	.509	.822	1.331
6	Blue Jays	19	8/12/2019	TOR	vs	TEX	W 19-4	43	21	9	0	4	19	4	0	7	1	1	47	42	13	0	0	0	0	.488	.532	.977	1.509
7	Blue Jays	19	8/9/1999	TOR	@	TEX	W 19-4	51	25	6	0	4	19	2	1	5	0	0	54	43	10	0	0	1	2	.490	.519	.843	1.362
8	Blue Jays	19	6/26/1983	TOR	@	SEA	W 19-7	46	21	3	0	4	18	9	1	6	0	0	57	36	7	0	1	0	1	.457	.544	.783	1.326
9	Blue Jays	19	9/10/1977	TOR	@	NYY	W 19-3	49	20	4	0	3	17	2	0	1	1	0	51	33	7	0	0	0	2	.408	.431	.673	1.105
10	Blue Jays	18	9/20/2022	TOR	@	PHI	W 18-11	49	21	7	1	2	17	3	1	8	0	0	53	36	10	0	0	0	1	.429	.472	.735	1.206
11	Blue Jays	18	6/13/2021	TOR	@	BOS	W 18-4	44	20	3	0	8	18	4	0	7	1	0	49	47	11	0	1	0	3	.455	.490	1.068	1.558
12	Blue Jays	18	8/31/2009	TOR	@	TEX	W 18-10	39	14	4	1	4	18	7	2	8	0	2	49	32	9	0	1	0	0	.359	.469	.821	1.290
13	Blue Jays	18	5/16/2003	TOR	@	KCR	W 18-1	48	22	4	0	1	15	5	2	9	0	0	56	29	5	0	1	0	0	.458	.518	.604	1.122
14	Blue Jays	18	7/29/1995	TOR	vs	OAK	W 18-11	37	16	5	0	3	17	9	3	6	0	0	50	30	8	0	1	0	1	.432	.560	.811	1.371
15	Blue Jays	18	9/14/1987	TOR	vs	BAL	W 18-3	44	21	2	0	10	18	4	0	4	0	0	48	53	12	0	0	0	1	.477	.521	1.205	1.725
16	Blue Jays	17	5/29/2017	TOR	vs	CIN	W 17-2	46	23	5	0	3	16	7	1	1	0	0	54	37	8	0	0	0	1	.500	.574	.804	1.378
17	Blue Jays	17	7/3/2016	TOR	vs	CLE	W 17-1	40	18	5	0	3	17	10	0	5	0	1	53	32	8	1	2	2	0	.450	.538	.800	1.338
18	Blue Jays	17	8/7/2010	TOR	vs	TBR	W 17-11	43	20	4	0	8	17	6	0	4	0	0	49	48	12	0	0	0	1	.465	.531	1.116	1.647
19	Blue Jays	17	4/20/1990	TOR	vs	KCR	W 17-6	42	19	2	1	5	17	7	1	2	0	0	51	38	8	1	0	0	0	.452	.540	.905	1.445
20	Blue Jays	17	4/11/1988	TOR	vs	NYY	W 17-9	44	20	5	0	2	16	9	2	4	2	0	56	31	7	0	1	0	1	.455	.554	.705	1.258
21	Blue Jays	16	7/14/2011	TOR	vs	NYY	W 16-7	43	20	5	0	0	14	3	0	5	1	0	46	25	5	0	0	0	2	.465	.500	.581	1.081
22	Blue Jays	16	8/20/2010	TOR	@	BOS	W 16-2	44	20	3	0	4	16	3	0	5	0	0	48	35	7	0	1	0	2	.455	.479	.795	1.275
23	Blue Jays	16	5/14/2010	TOR	vs	TEX	W 16-10	38	15	3	0	5	16	9	0	6	1	0	47	33	8	0	0	0	0	.395	.511	.868	1.379
24	Blue Jays	16	9/19/2000	TOR	vs	NYY	W 16-3	42	19	6	0	1	14	6	0	4	0	0	48	28	7	0	0	0	3	.452	.521	.667	1.188
25	Blue Jays	16	5/3/1999	TOR	@	SEA	W 16-10	44	17	5	0	4	16	4	1	7	0	0	50	34	9	0	1	1	1	.386	.440	.773	1.213