Since 2010, the Minnesota Twins and the Washington Nationals are tied for the most runs in a loss, with 14 runs.

Interpreted as:

most runs in a regular-season loss since 2010

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Twins	14	1	7/28/2021	MIN	vs	DET	L 14-17	0	1.000	43	16	1	0	7	14	7	1	8	0	0	51	38	8	0	0	0	0	.372	.471	.884	1.354
2	Nationals	14	1	8/17/2019	WSH	vs	MIL	L 14-15	0	1.000	58	18	6	0	4	13	10	0	13	1	0	69	36	10	0	1	2	2	.310	.406	.621	1.026
3	Braves	13	1	7/18/2023	ATL	vs	ARI	L 13-16	0	1.000	37	11	4	0	3	13	4	0	5	1	0	41	24	7	0	0	0	0	.297	.366	.649	1.015
4	Cubs	13	1	8/27/2021	CHC	@	CWS	L 13-17	0	1.000	39	13	3	0	4	12	3	0	12	0	2	42	28	7	0	0	0	0	.333	.381	.718	1.099
5	Pirates	13	1	8/7/2020	PIT	vs	DET	L 13-17	0	1.000	47	16	2	0	3	13	4	0	8	0	0	52	27	5	0	1	0	1	.340	.385	.574	.959
6	Red Sox	13	1	6/29/2019	BOS	vs	NYY	L 13-17	0	1.000	43	18	3	0	3	12	6	0	5	0	0	50	30	6	0	1	0	1	.419	.480	.698	1.178
7	Rockies	13	1	6/16/2019	COL	vs	SDP	L 13-14	0	1.000	46	19	5	0	2	13	2	0	14	0	0	48	30	7	0	0	1	0	.413	.438	.652	1.090
8	Padres	13	1	6/2/2016	SDP	vs	SEA	L 13-16	0	1.000	47	20	2	1	0	11	3	1	10	0	0	51	24	3	0	0	0	1	.426	.471	.511	.981
9	Red Sox	13	1	8/23/2012	BOS	vs	LAA	L 13-14	0	1.000	48	18	4	0	3	13	1	0	12	1	1	49	31	7	0	0	0	0	.375	.388	.646	1.034
10	Phillies	13	1	5/2/2012	PHI	@	ATL	L 13-15	0	1.000	49	17	4	0	1	13	5	1	9	2	0	55	24	5	0	0	0	1	.347	.418	.490	.908
11	Diamondbacks	12	1	5/17/2025	AZ	vs	COL	L 12-14	0	1.000	43	15	5	1	2	10	4	1	7	2	0	49	28	8	0	1	0	0	.349	.408	.651	1.059
12	Twins	12	1	7/5/2024	MIN	vs	HOU	L 12-13	0	1.000	42	17	5	0	2	12	4	1	9	0	0	48	28	7	1	0	0	1	.405	.468	.667	1.135
13	Reds	12	1	9/23/2023	CIN	vs	PIT	L 12-13	0	1.000	41	16	4	0	3	12	5	0	8	3	0	46	29	7	0	0	0	1	.390	.457	.707	1.164
14	Red Sox	12	1	9/9/2023	BOS	vs	BAL	L 12-13	0	1.000	50	23	4	0	1	11	2	0	8	2	0	53	30	5	0	1	0	1	.460	.472	.600	1.072
15	Astros	12	1	7/15/2023	HOU	@	LAA	L 12-13	0	1.000	44	16	2	0	2	12	4	0	9	0	1	49	24	4	0	1	1	0	.364	.408	.545	.954
16	Mariners	12	1	9/25/2022	SEA	@	KCR	L 12-13	0	1.000	36	12	3	0	0	12	8	3	6	0	1	48	15	3	0	1	0	1	.333	.479	.417	.896
17	Marlins	12	1	6/1/2022	MIA	@	COL	L 12-13	0	1.000	41	13	1	0	3	11	9	0	6	3	0	51	23	4	0	1	0	2	.317	.431	.561	.992
18	Mets	12	1	5/24/2022	NYM	@	SFG	L 12-13	0	1.000	42	18	2	2	1	12	1	1	7	1	0	47	27	5	0	3	0	0	.429	.426	.643	1.068
19	Phillies	12	1	6/23/2021	PHI	vs	WSH	L 12-13	0	1.000	43	15	2	0	3	12	6	1	5	1	0	50	26	5	0	0	0	0	.349	.440	.605	1.045
20	Cubs	12	1	5/2/2021	CHC	@	CIN	L 12-13	0	1.000	42	14	4	0	5	12	3	0	9	2	2	45	33	9	0	0	1	0	.333	.378	.786	1.163
21	Twins	12	1	4/21/2021	MIN	@	OAK	L 12-13	0	1.000	49	18	4	0	4	10	2	0	10	1	0	51	34	8	0	0	0	1	.367	.392	.694	1.086
22	Twins	12	1	7/23/2019	MIN	vs	NYY	L 12-14	0	1.000	44	15	3	0	4	12	8	2	8	0	0	55	30	7	0	1	0	1	.341	.455	.682	1.136
23	Rockies	12	1	6/14/2019	COL	vs	SDP	L 12-16	0	1.000	53	18	3	0	3	11	2	2	9	1	0	58	30	6	0	1	0	0	.340	.379	.566	.945
24	Reds	12	1	8/29/2018	CIN	vs	MIL	L 12-13	0	1.000	42	14	2	0	5	11	6	1	11	1	1	49	31	7	0	0	0	0	.333	.429	.738	1.167
25	Orioles	12	1	8/10/2018	BAL	vs	BOS	L 12-19	0	1.000	41	17	3	0	3	11	4	0	10	1	1	47	29	6	1	1	0	1	.415	.457	.707	1.164