The Minnesota Twins had their most runs in a game versus the Tigers on April 24, 1996, with 24 runs.

Interpreted as:

most runs in single twins regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Twins	24	4/24/1996	MIN	@	DET	W 24-11	46	19	4	1	3	22	12	1	5	2	0	60	34	8	0	1	1	0	.413	.533	.739	1.272
2	Twins	23	6/4/2002	MIN	vs	CLE	W 23-2	50	25	6	1	3	22	7	0	4	0	0	57	42	10	0	0	1	0	.500	.561	.840	1.401
3	Twins	21	6/4/1994	MIN	@	DET	W 21-7	49	24	3	0	4	20	5	1	8	0	0	57	39	7	1	1	0	1	.490	.536	.796	1.332
4	Twins	21	5/20/1994	MIN	vs	BOS	W 21-2	44	22	5	0	1	21	7	1	6	1	0	54	30	6	0	2	0	0	.500	.556	.682	1.237
5	Senators	21	8/5/1929	WSH	vs	DET	W 21-5	41	21	1	2	1	16	6	0	1	4	0	51	29	4	4				.512	.574	.707	1.282
6	Twins	20	9/4/2023	MIN	@	CLE	W 20-6	46	20	2	0	6	20	6	0	4	0	0	53	40	8	0	1	0	0	.435	.491	.870	1.360
7	Twins	20	6/13/2017	MIN	vs	SEA	W 20-7	49	28	2	0	5	19	2	0	4	0	0	51	45	7	0	0	0	1	.571	.588	.918	1.507
8	Twins	20	8/22/2014	MIN	vs	DET	W 20-6	46	20	4	1	4	18	9	0	8	1	0	55	38	9	0	0	0	0	.435	.527	.826	1.353
9	Twins	20	5/21/2009	MIN	@	CWS	W 20-1	46	20	4	0	4	18	5	1	5	0	0	54	36	8	1	1	1	0	.435	.491	.783	1.273
10	Twins	20	7/6/2007	MIN	@	CWS	W 20-14	47	21	4	0	2	20	8	0	1	0	0	57	31	6	0	2	1	1	.447	.509	.660	1.168
11	Twins	20	4/27/1980	MIN	vs	OAK	W 20-11	41	20	1	2	0	19	8	1	5	0	1	52	25	3	0	2	0	2	.488	.558	.610	1.167
12	Senators	20	8/1/1943	WSH	vs	SLA	W 20-6	41	19	4	1	0	18	12	2	3	5	0	56	25	5	1			1	.463	.600	.610	1.210
13	Senators	20	8/22/1925	WSH	@	DET	W 20-5	44	19	5	1	3	18	10	0	1	0	0	55	35	9	1				.432	.537	.795	1.332
14	Senators	20	8/24/1923	WSH	@	CLE	W 20-8	42	22	6	3	0	18	14	0	0	3	2	59	34	9	3				.524	.643	.810	1.452
15	Senators	20	9/29/1915	WSH	vs	PHA	W 20-5	43	23	4	2	0		4	1	3	7		52	31	6	4				.535	.583	.721	1.304
16	Senators	20	9/7/1901	WSH	@	MIL	W 20-8	39	15	4	0	0	13	7	1	-10	3	-10	47	19	4	0		-10	-10	.385	.489	.487	.977
17	Twins	19	7/16/2012	MIN	vs	BAL	W 19-7	41	20	6	0	1	17	5	1	3	1	1	48	29	7	0	1	0	2	.488	.542	.707	1.249
18	Twins	19	7/26/2010	MIN	@	KCR	W 19-1	44	20	7	2	2	19	6	1	12	0	0	52	37	11	0	1	0	1	.455	.519	.841	1.360
19	Twins	19	5/20/1989	MIN	@	TEX	W 19-3	46	20	2	0	4	19	8	0	6	1	0	55	34	6	0	1	0	0	.435	.509	.739	1.248
20	Twins	19	6/26/1977	MIN	vs	CWS	W 19-12	39	18	4	1	2	17	11	0	6	0	1	52	30	7	1	1	1	0	.462	.569	.769	1.338
21	Senators	19	7/10/1926	WSH	vs	SLA	W 19-4	40	19	4	2	0	16	7	0	2	3	1	48	27	6	1				.475	.553	.675	1.228
22	Senators	19	7/18/1925	WSH	@	CLE	W 19-6	44	24	5	3	1	18	3	1	2	3	1	52	38	9	4				.545	.583	.864	1.447
23	Senators	19	7/27/1920	WSH	@	CLE	W 19-6	48	22	2	0	0	16	7	0	7	3	0	56	24	2	1				.458	.527	.500	1.027
24	Twins	18	5/18/2019	MIN	@	SEA	W 18-4	46	19	5	0	6	18	6	0	5	0	0	53	42	11	0	1	0	0	.413	.472	.913	1.385
25	Twins	18	9/4/2012	MIN	@	CWS	W 18-9	41	17	0	1	2	18	8	0	7	0	0	51	25	3	0	2	0	1	.415	.490	.610	1.100