4 players are tied for the most runs for the Orioles in a game, with 5 runs. The first three are Cal Ripken Jr. on June 13, 1999, Roy Cullenbine on July 31, 1941 and Ski Melillo on June 22, 1931.

Interpreted as:

most runs scored regular-season game by orioles player

	NAME	R	DATE	TM		OPP	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Cal Ripken Jr. C. Ripken Jr.	5	6/13/1999	BAL	@	ATL	6	6	1	0	2	6	0	0	0	0	0	6	13	3	0	0	0	0
2	Roy Cullenbine R. Cullenbine	5	7/31/1941	SLA	@	BSA	2	1	0	0	1	5	3	1	0	0	0	6	4	1	0			0
3	Ski Melillo S. Melillo	5	6/22/1931	SLA	vs	NYY	3	3	0	0	0	2	3	0	0	0	0	6	3	0	0
4	George Sisler G. Sisler	5	4/19/1922	SLA	@	CLE	6	4	1	1	0	0	0	0	0	3	0	6	7	2	0
5	George Sisler G. Sisler	5	5/30/1921	SLA	@	CWS	5	3	1	0	1	2	1	0	0	2	0	6	7	2	0
6	Ramón Laureano R. Laureano	4	6/27/2025	BAL	vs	TBR	3	2	1	0	0	2	2	0	1	1	0	5	3	1	0	0	0	0
7	Colton Cowser C. Cowser	4	6/27/2025	BAL	vs	TBR	4	3	3	0	0	2	2	0	0	0	0	6	6	3	0	0	0	0
8	Ryan O'Hearn R. O'Hearn	4	6/11/2023	BAL	vs	KCR	3	3	0	0	1	1	2	0	0	0	0	5	6	1	0	0	0	0
9	Adam Frazier A. Frazier	4	5/4/2023	BAL	@	KCR	3	2	0	0	0	0	2	0	0	1	0	5	2	0	0	0	0	0
10	Austin Hays A. Hays	4	4/11/2023	BAL	vs	OAK	5	4	1	0	1	2	0	0	1	0	0	5	8	2	0	0	0	0
11	Ryan Mountcastle R. Mountcastle	4	5/30/2022	BAL	@	BOS	5	4	1	0	1	1	0	0	0	0	0	5	8	2	0	0	0	1
12	Chris Davis C. Davis	4	5/20/2014	BAL	@	PIT	5	4	0	0	3	5	0	0	1	0	0	5	13	3	0	0	0	0
13	Nate McLouth N. McLouth	4	4/28/2013	BAL	@	OAK	5	4	1	0	0	0	0	0	0	1	0	5	5	1	0	0	0	0
14	Adam Jones A. Jones	4	9/17/2012	BAL	@	SEA	4	3	1	0	0	1	1	0	0	0	0	5	4	1	0	0	0	0
15	Ty Wigginton T. Wigginton	4	6/14/2009	BAL	vs	ATL	4	3	0	0	2	3	1	0	0	0	0	5	9	2	0	0	0	0
16	Melvin Mora M. Mora	4	8/17/2008	BAL	@	DET	6	5	2	0	2	6	0	0	0	0	0	6	13	4	0	0	0	0
17	Kevin Millar K. Millar	4	8/14/2007	BAL	@	NYY	3	3	0	0	1	1	2	0	0	0	0	5	6	1	0	0	0	0
18	Ramon Hernandez R. Hernandez	4	9/17/2006	BAL	@	DET	4	4	2	0	0	1	1	1	0	0	0	6	6	2	0	0	1	0
19	Bernie Castro B. Castro	4	9/27/2005	BAL	vs	NYY	5	3	1	0	0	0	1	0	0	0	0	6	4	1	0	0	0	0
20	Melvin Mora M. Mora	4	9/27/2005	BAL	vs	NYY	5	2	1	0	1	5	1	0	1	0	0	6	6	2	0	0	0	0
21	Javy Lopez J. Lopez	4	4/22/2005	BAL	@	TOR	4	3	1	0	1	2	1	0	0	0	0	5	7	2	0	0	1	0
22	David Newhan D. Newhan	4	7/21/2004	BAL	@	BOS	5	4	1	0	1	2	0	0	0	0	0	5	8	2	0	0	0	0
23	Jerry Hairston J. Hairston	4	7/5/2004	BAL	vs	TBD	5	4	2	0	0	1	0	0	0	0	0	5	6	2	0	0	0	0
24	Melvin Mora M. Mora	4	6/9/2004	BAL	vs	ARI	3	1	1	0	0	0	1	1	0	0	0	5	2	1	0	0	0	0
25	Brian Roberts B. Roberts	4	5/4/2004	BAL	vs	CWS	4	3	1	0	0	0	1	0	0	4	0	5	4	1	0	0	0	0