Shohei Ohtani has put up the most runs by a designated hitter in a season, with 146 runs in 2025.

	NAME	R	SEASON	TM	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Shohei Ohtani S. Ohtani	146	2025	LAD	158	611	172	25	9	55	102	109	3	187	20	6	725	380	89	0	2	20	9	.282	.392	.622	1.014	147	61.7	.418	173	63.1
2	Shohei Ohtani S. Ohtani	134	2024	LAD	159	636	197	38	7	54	130	81	6	162	59	4	728	411	99	0	5	10	7	.310	.390	.646	1.036	156	70.5	.431	181	70.3
3	Paul Molitor P. Molitor	133	1991	MIL	158	665	216	32	13	17	75	77	6	62	19	8	749	325	62	0	1	16	11	.325	.399	.489	.888	127	42.1	.391	145	39.8
4	Edgar Martinez E. Martinez	121	1996	SEA	139	499	163	52	2	26	103	123	8	84	3	3	634	297	80	0	4	12	15	.327	.464	.595	1.059	144	62.2	.450	164	56
5	Edgar Martinez E. Martinez	121	1995	SEA	145	511	182	52	0	29	113	116	8	87	4	3	639	321	81	0	4	19	11	.356	.479	.628	1.107	152	72.5	.469	182	68.8
6	Paul Molitor P. Molitor	121	1993	TOR	160	636	211	37	5	22	111	77	3	71	22	4	725	324	64	1	8	3	13	.332	.402	.509	.911	130	43.3	.401	145	39.9
7	David Ortiz D. Ortiz	119	2005	BOS	159	601	180	40	1	47	148	102	1	124	1	0	713	363	88	0	9	9	13	.300	.397	.604	1.001	140	54.5	.418	157	49.5
8	David Ortiz D. Ortiz	116	2007	BOS	149	549	182	52	1	35	117	111	4	103	3	1	667	341	88	0	3	12	16	.332	.445	.621	1.066	149	66.2	.449	175	62.6
9	David Ortiz D. Ortiz	115	2006	BOS	151	558	160	29	2	54	137	119	4	117	1	0	686	355	85	0	5	23	12	.287	.413	.636	1.049	142	56	.427	157	50.9
10	Frank Thomas F. Thomas	115	2000	CWS	159	582	191	44	0	43	143	112	5	94	1	3	707	364	87	0	8	18	13	.328	.436	.625	1.061	155	61.7	.441	160	57.6
11	Paul Molitor P. Molitor	114	1987	MIL	118	465	164	41	5	16	75	69	2	67	45	10	542	263	62	5	1	2	4	.353	.438	.566	1.003	115	48.3	.433	165	44.5
12	Kyle Schwarber K. Schwarber	111	2025	PHI	162	604	145	23	2	56	132	108	11	197	10	2	724	340	81	0	1	6	4	.240	.365	.563	.928	132	46	.391	153	45.8
13	J.D. Martinez	111	2018	BOS	150	569	188	37	2	43	130	69	4	146	6	1	649	358	82	0	7	11	19	.330	.402	.629	1.031	136	59.7	.427	171	54.9
14	Kyle Schwarber K. Schwarber	110	2024	PHI	150	573	142	22	0	38	104	106	5	197	5	3	692	278	60	0	8	4	6	.248	.366	.485	.851	112	31	.366	135	29.2
15	Brian Downing B. Downing	110	1987	CAL	155	567	154	29	3	29	77	106	17	85	5	5	695	276	61	2	3	6	10	.272	.400	.487	.886	121	35.4	.387	138	34
16	Frank Thomas F. Thomas	109	1998	CWS	160	585	155	35	2	29	109	110	6	93	7	0	712	281	66	0	11	2	14	.265	.381	.480	.861	115	26.4	.376	126	23.9
17	Jim Thome J. Thome	108	2006	CWS	143	490	141	26	0	42	109	107	6	147	0	0	610	293	68	0	7	12	4	.288	.416	.598	1.014	123	46.5	.421	152	41.3
18	Gary Sheffield G. Sheffield	107	2007	DET	133	494	131	20	1	25	75	84	9	71	22	5	593	228	46	0	6	2	10	.265	.378	.462	.839	92	18.6	.368	123	16.8
19	George Springer G. Springer	106	2025	TOR	140	498	154	27	1	32	84	69	8	111	18	1	579	279	60	0	4	3	14	.309	.399	.560	.959	113	44.6	.408	167	45.4
20	Edgar Martinez E. Martinez	104	1997	SEA	155	542	179	35	1	28	108	119	11	86	2	4	678	300	64	0	6	11	21	.330	.456	.554	1.009	142	58.6	.436	164	55.5
21	Frank Thomas F. Thomas	104	1991	CWS	158	559	178	31	2	32	109	138	1	112	1	2	700	309	65	0	2	13	20	.318	.453	.553	1.006	146	66.8	.442	179	65.4
22	Hal McRae H. McRae	104	1977	KCR	162	641	191	54	11	21	92	59	13	43	18	14	720	330	86	2	5	5	12	.298	.366	.515	.881	118	34.1	.383	137	31.9
23	Jim Rice J. Rice	104	1977	BOS	160	644	206	29	15	39	114	53	8	120	5	4	710	382	83	0	5	10	21	.320	.376	.593	.969	134	51.2	.414	150	42.4
24	Shohei Ohtani S. Ohtani	103	2021	LAA	155	537	138	26	8	46	100	96	4	189	26	10	639	318	80	0	2	20	7	.257	.372	.592	.965	119	41.8	.393	150	39.4
25	Don Baylor D. Baylor	103	1978	CAL	158	591	151	26	0	34	99	56	18	71	22	9	677	279	60	0	12	9	15	.255	.332	.472	.804	93	19.4	.356	126	20