most strikeouts against one team career pitcher

Mickey Mantle has the most career strikeouts by a player against a team, with 262 strikeouts against the Cleveland Indians.

Interpreted as:

most strikeouts by a player against one team career pitcher

	NAME	SO	OPP	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mickey Mantle M. Mantle	262	Indians	316	1,059	208	290	34	5	65	183	246	0	13	5	1,313	529	104	0	8	21	15	.274	.408	.500	.908
2	Mickey Mantle M. Mantle	250	Tigers	325	1,146	227	343	44	7	73	205	210	1	14	7	1,368	620	124	3	8	17	14	.299	.406	.541	.947
3	Reggie Jackson R. Jackson	249	Tigers	235	848	115	208	37	5	38	132	98	8	15	11	962	369	80	1	7	9	14	.245	.327	.435	.762
4	Reggie Jackson R. Jackson	243	Twins	252	902	144	225	54	4	51	142	102	9	9	8	1,018	440	109	1	4	13	20	.249	.330	.488	.818
5	Mike Schmidt M. Schmidt	234	Pirates	264	927	163	220	40	4	62	188	155	10	14	10	1,110	454	106	3	15	27	18	.237	.348	.490	.838
6	Reggie Jackson R. Jackson	231	White Sox	249	885	140	237	42	4	46	136	115	9	32	10	1,014	425	92	0	5	20	14	.268	.356	.480	.836
7	Mickey Mantle M. Mantle	231	White Sox	322	1,121	210	329	54	10	72	192	206	0	23	6	1,333	619	136	3	3	23	22	.293	.402	.552	.954
8	Chris Davis C. Davis	230	Yankees	156	538	71	120	22	0	32	89	53	8	0	0	606	238	54	0	7	6	7	.223	.299	.442	.741
9	Mickey Mantle M. Mantle	230	Red Sox	299	972	211	296	42	9	69	195	230	3	20	5	1,209	563	120	3	1	11	13	.305	.439	.579	1.018
10	Alex Rodriguez A. Rodriguez	228	Blue Jays	242	923	160	248	50	0	58	178	112	18	22	6	1,060	472	108	0	7	13	31	.269	.357	.511	.868
11	Alex Rodriguez A. Rodriguez	223	Red Sox	265	996	195	282	46	3	59	170	133	21	48	8	1,159	511	108	0	9	6	27	.283	.376	.513	.889
12	Reggie Jackson R. Jackson	223	Red Sox	236	832	123	221	50	3	51	149	121	6	25	5	964	430	104	0	5	16	11	.266	.361	.517	.878
13	Mike Schmidt M. Schmidt	222	Cubs	269	971	189	284	39	12	78	207	146	11	17	6	1,142	581	129	2	12	31	20	.292	.387	.598	.985
14	Mike Schmidt M. Schmidt	222	Expos	262	914	157	232	49	6	57	161	150	6	13	4	1,083	464	112	2	11	17	19	.254	.359	.508	.867
15	Jim Thome J. Thome	221	Twins	196	695	148	218	34	3	61	156	118	6	2	2	826	441	98	1	6	9	12	.314	.415	.635	1.049
16	Alex Rodriguez A. Rodriguez	219	Rays	231	877	157	234	51	2	56	160	105	15	23	7	1,002	457	109	0	5	7	22	.267	.353	.521	.874
17	Willie Stargell W. Stargell	217	Phillies	279	875	138	241	46	9	44	171	123	18	2	1	1,026	437	99	1	9	37	20	.275	.373	.499	.872
18	Reggie Jackson R. Jackson	216	Indians	229	787	132	200	35	7	42	139	114	9	14	5	917	375	84	2	5	18	12	.254	.353	.476	.829
19	Mickey Mantle M. Mantle	216	Orioles	312	1,048	206	305	61	15	50	179	218	3	23	7	1,279	546	126	2	8	9	18	.291	.412	.521	.933
20	Mickey Mantle M. Mantle	214	Twins	304	1,071	216	313	37	11	72	183	190	2	17	3	1,272	588	120	2	7	12	12	.292	.398	.549	.947
21	Reggie Jackson R. Jackson	212	Angels	206	745	118	198	35	8	40	131	106	11	24	12	869	369	83	3	4	6	12	.266	.364	.495	.859
22	Willie McCovey W. McCovey	212	Dodgers	297	918	123	221	30	5	45	162	142	7	3	5	1,074	396	80	1	6	24	10	.241	.345	.431	.776
23	Jim Thome J. Thome	211	Tigers	221	718	159	212	38	4	66	154	168	10	1	2	900	456	108	0	4	16	9	.295	.433	.635	1.068
24	Ryan Howard R. Howard	210	Nationals	176	632	86	160	28	2	44	134	79	12	2	0	725	324	74	0	2	25	12	.253	.346	.513	.859
25	Derek Jeter D. Jeter	210	Blue Jays	269	1,087	186	341	50	8	24	110	108	18	31	7	1,228	479	82	11	4	4	25	.314	.384	.441	.824