Randy Johnson struck out the most hitters in 2000, with 347 strikeouts.

	NAME	SO	SEASON	TM	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Randy Johnson R. Johnson	347	2000	ARI	35	19	7	.731	35	2.64	8	3	0	248.2	202	73	89	23	76	6	0	1	1,001	5	12.56	2.75	4.57	0.83	34.7	7.6	1.12	.326	3.22	56	2.53	53	7.31	61.1
2	Pedro Martinez P. Martinez	284	2000	BOS	29	18	6	.750	29	1.74	7	4	0	217.0	128	42	44	17	32	14	0	0	817	1	11.78	1.33	8.88	0.71	34.8	3.9	0.74	.236	1.82	35	2.16	47	5.31	61.5
3	Chan Ho Park C. Ho Park	217	2000	LAD	34	18	10	.643	34	3.27	3	1	0	226.0	173	82	92	21	124	12	0	4	963	13	8.64	4.94	1.75	0.84	22.5	12.9	1.31	.258	3.66	76	4.22	91	6.89	11.1
4	Kevin Brown K. Brown	216	2000	LAD	33	13	6	.684	33	2.58	5	1	0	230.0	181	66	76	21	47	9	0	1	921	4	8.45	1.84	4.60	0.82	23.5	5.1	0.99	.255	2.97	60	3.16	68	7.08	38.5
5	Bartolo Colon B. Colon	212	2000	CLE	30	15	8	.652	30	3.88	2	1	0	188.0	163	81	86	21	98	4	0	4	807	4	10.15	4.69	2.16	1.01	26.3	12.1	1.39	.301	4.12	77	3.95	80	7.80	20
6	Mike Mussina M. Mussina	210	2000	BAL	34	11	15	.423	34	3.79	6	1	0	237.2	236	100	105	28	46	3	0	0	987	3	7.95	1.74	4.57	1.06	21.3	4.7	1.19	.297	3.98	80	3.51	73	8.94	34.7
7	Ryan Dempster R. Dempster	209	2000	FLA	33	14	10	.583	33	3.66	2	1	0	226.1	210	92	102	30	97	5	0	7	974	4	8.31	3.86	2.15	1.19	21.5	10.0	1.36	.284	4.06	82	4.35	95	8.35	5.2
8	Al Leiter A. Leiter	200	2000	NYM	31	16	8	.667	31	3.20	2	1	0	208.0	176	74	84	19	76	11	0	1	874	4	8.65	3.29	2.63	0.82	22.9	8.7	1.21	.276	3.63	72	3.64	80	7.62	21.6
9	Javier Vazquez J. Vazquez	196	2000	MON	33	11	9	.550	33	4.05	2	1	0	217.2	247	98	104	24	61	5	0	10	945	3	8.10	2.52	3.21	0.99	20.7	6.5	1.42	.338	4.30	88	3.67	78	10.21	25.1
10	Rick Ankiel R. Ankiel	194	2000	STL	31	11	7	.611	30	3.50	0	0	0	175.0	137	68	80	21	90	6	0	2	735	12	9.98	4.63	2.16	1.08	26.4	12.2	1.30	.274	4.11	76	4.11	86	7.05	13.3
11	Pedro Astacio P. Astacio	193	2000	COL	32	12	9	.571	32	5.27	3	0	0	196.1	217	115	119	32	77	15	0	5	875	8	8.85	3.53	2.51	1.47	22.1	8.8	1.50	.332	5.46	93	4.68	90	9.95	11.6
12	Darryl Kile D. Kile	192	2000	STL	34	20	9	.690	34	3.91	5	1	0	232.1	215	101	109	33	58	13	0	1	960	8	7.44	2.25	3.31	1.28	20.0	6.0	1.18	.274	4.22	85	4.24	88	8.33	14.5
13	Jon Lieber J. Lieber	192	2000	CHC	35	12	11	.522	35	4.41	6	1	0	251.0	248	123	130	36	54	10	0	3	1,047	2	6.88	1.94	3.56	1.29	18.3	5.2	1.20	.281	4.66	97	4.23	90	8.89	13.4
14	Greg Maddux G. Maddux	190	2000	ATL	35	19	9	.679	35	3.00	6	3	0	249.1	225	83	91	19	42	10	0	12	1,012	1	6.86	1.52	4.52	0.69	18.8	4.2	1.07	.274	3.28	65	3.22	69	8.12	40.2
15	Chuck Finley C. Finley	189	2000	CLE	34	16	11	.593	34	4.17	3	0	0	218.0	211	101	108	23	101	2	0	3	936	9	7.80	4.17	1.87	0.95	20.2	10.8	1.43	.303	4.46	82	4.18	85	8.71	17.8
16	Roger Clemens R. Clemens	188	2000	NYY	32	13	8	.619	32	3.70	1	0	0	204.1	184	84	96	26	84	10	0	0	878	2	8.28	3.70	2.24	1.15	21.4	9.6	1.31	.277	4.23	77	4.32	90	8.10	11.4
17	Kris Benson K. Benson	184	2000	PIT	32	10	12	.455	32	3.85	2	1	0	217.2	206	93	104	24	86	10	0	5	936	5	7.61	3.56	2.14	0.99	19.7	9.2	1.34	.288	4.30	82	4.19	90	8.52	11.3
18	Hideo Nomo H. Nomo	181	2000	DET	32	8	12	.400	31	4.74	1	0	0	190.0	191	100	102	31	89	3	0	1	828	16	8.57	4.22	2.03	1.47	21.9	10.7	1.47	.305	4.83	99	4.79	102	9.05	-2.8
19	Dave Burba D. Burba	180	2000	CLE	32	16	6	.727	32	4.47	0	0	0	191.1	199	95	99	19	91	2	0	2	848	7	8.47	4.28	1.98	0.89	21.2	10.7	1.52	.324	4.66	88	3.99	81	9.36	19.5
20	Matt Clement M. Clement	170	2000	SDP	34	13	17	.433	34	5.14	0	0	0	205.0	194	117	131	22	125	16	0	4	940	23	7.46	5.49	1.36	0.97	18.1	13.3	1.56	.283	5.75	119	4.93	109	8.52	-10.1
21	Tim Hudson T. Hudson	169	2000	OAK	32	20	6	.769	32	4.14	2	2	0	202.1	169	93	100	24	82	7	0	5	847	7	7.52	3.65	2.06	1.07	20.0	9.7	1.24	.257	4.45	86	4.32	90	7.52	10.3
22	Kevin Millwood K. Millwood	168	2000	ATL	36	10	13	.435	35	4.66	0	0	0	212.2	213	110	115	26	62	3	0	2	903	4	7.11	2.62	2.71	1.10	18.6	6.9	1.29	.290	4.87	102	4.05	87	9.01	14.4
23	Curt Schilling C. Schilling	168	2000	TOT	29	11	12	.478	29	3.81	8	2	0	210.1	204	89	90	27	45	1	0	4	862	4	7.19	1.93	3.73	1.16	19.5	5.2	1.18	.285	3.85	82	3.85	83	8.73	19.2
24	Russ Ortiz R. Ortiz	167	2000	SFG	33	14	12	.538	32	5.01	0	0	0	195.2	192	109	117	28	112	7	0	1	871	8	7.68	5.15	1.49	1.29	19.2	12.9	1.55	.294	5.38	113	5.10	114	8.83	-15
25	David Wells D. Wells	166	2000	TOR	35	20	8	.714	35	4.11	9	1	0	229.2	266	105	115	23	31	8	0	0	972	9	6.51	1.21	5.35	0.90	17.1	3.2	1.29	.327	4.51	82	3.49	72	10.42	34