Max Scherzer has struck out the most batters by an active pitcher in a game, with 20 strikeouts versus the Tigers on May 11, 2016.
Interpreted as:
most strikeouts by a pitcher in a regular-season game by an active player| NAME | SO | DATE | TM | OPP | DEC | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Scherzer | 20 | 5/11/2016 |  WSH | vs |  DET | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 6 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 33 | 0 |
| 2 |  | C. Sale | 17 | 5/14/2019 |  BOS | vs |  COL | 1 | 2.57 | 0 | 0 | 0 | 7.0 | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 24 | 0 | |
| 3 | | M. Scherzer | 17 | 10/3/2015 | WSH | @ |  NYM | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 28 | 0 |
| 4 |  | S. Strider | 16 | 9/1/2022 |  ATL | vs | COL | W | 1 | 0.00 | 0 | 0 | 0 | 8.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27 | 0 |
| 5 |  | W. Buehler | 16 | 6/21/2019 |  LAD | vs | COL | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 3 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 30 | 0 |
| 6 |  | G. Cole | 16 | 5/4/2018 |  HOU | @ |  ARI | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 29 | 0 |
| 7 |  | J. Gray | 16 | 9/17/2016 | COL | vs |  SDP | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 0 |
| 8 | | M. Scherzer | 16 | 6/14/2015 | WSH | @ |  MIL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 29 | 0 |
| 9 |  | B. Snell | 15 | 7/27/2024 |  SFG | vs | COL | 1 | 0.00 | 0 | 0 | 0 | 6.0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 22 | 1 | |
| 10 |  | G. Cole | 15 | 9/1/2021 |  NYY | @ |  LAA | W | 1 | 1.29 | 0 | 0 | 0 | 7.0 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 25 | 0 |
| 11 |  | C. Burnes | 15 | 8/11/2021 |  MIL | @ |  CHC | W | 1 | 0.00 | 0 | 0 | 0 | 8.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27 | 0 |
| 12 |  | J. deGrom | 15 | 4/23/2021 | NYM | vs | WSH | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 0 |
| 13 | | G. Cole | 15 | 9/8/2019 | HOU | vs |  SEA | W | 1 | 1.13 | 0 | 0 | 0 | 8.0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 25 | 0 |
| 14 | | W. Buehler | 15 | 8/3/2019 | LAD | vs | SDP | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 5 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 31 | 1 |
| 15 |  | J. Verlander | 15 | 6/12/2019 | HOU | vs | MIL | 1 | 3.86 | 0 | 0 | 0 | 7.0 | 4 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 25 | 0 | |
| 16 | | M. Scherzer | 15 | 6/2/2019 | WSH | @ |  CIN | W | 1 | 1.13 | 0 | 0 | 0 | 8.0 | 3 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 29 | 0 |
| 17 |  | S. Bieber | 15 | 5/19/2019 |  CLE | vs |  BAL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 0 |
| 18 | | C. Sale | 15 | 5/11/2018 | BOS | @ |  TOR | 1 | 3.00 | 0 | 0 | 0 | 9.0 | 6 | 3 | 3 | 1 | 0 | 0 | 0 | 0 | 33 | 0 | |
| 19 | | M. Scherzer | 15 | 5/6/2018 | WSH | vs |  PHI | 1 | 1.42 | 0 | 0 | 0 | 6.1 | 5 | 1 | 1 | 0 | 2 | 1 | 0 | 1 | 26 | 0 | |
| 20 |  | C. Kershaw | 15 | 9/2/2015 | LAD | vs | SFG | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 6 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 32 | 0 |
| 21 |  | C. Sale | 15 | 8/16/2015 |  CWS | vs | CHC | W | 1 | 0.00 | 0 | 0 | 0 | 7.0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 26 | 0 |
| 22 | | C. Kershaw | 15 | 6/18/2014 | LAD | vs | COL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 28 | 0 |
| 23 |  | Y. Darvish | 15 | 8/12/2013 |  TEX | @ | HOU | W | 1 | 1.13 | 0 | 0 | 0 | 8.0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 26 | 0 |
| 24 | | C. Sale | 15 | 5/28/2012 | CWS | @ |  TBR | W | 1 | 1.23 | 0 | 0 | 0 | 7.1 | 3 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 27 | 0 |
| 25 |  | M. Scherzer | 15 | 5/20/2012 | DET | vs |  PIT | W | 1 | 2.57 | 0 | 0 | 0 | 7.0 | 4 | 2 | 2 | 2 | 1 | 0 | 0 | 0 | 26 | 0 |
Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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CLE 
STL 
Padres 
Athletics 
