Since 2000, 4 pitchers are tied for striking out the most hitters in a game with more than 9 earned runs, with 7 strikeouts. The first three are Joe Ryan on July 29, 2022, Ryan Weber on June 13, 2021 and Ben Sheets on August 15, 2005.
Interpreted as:
most strikeouts by pitcher single regular-season game and over 9 er single game since 2000| NAME | SO | ER | DATE | TM | OPP | DEC | GS | ERA | CG | SHO | SV | IP | H | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Ryan | 7 | 10 | 7/29/2022 |  MIN | @ |  SDP | L | 1 | 19.29 | 0 | 0 | 0 | 4.2 | 8 | 10 | 5 | 2 | 0 | 0 | 0 | 24 | 0 |
| 2 |  | R. Weber | 7 | 11 | 6/13/2021 |  BOS | vs |  TOR | 0 | 17.47 | 0 | 0 | 0 | 5.2 | 13 | 11 | 4 | 2 | 0 | 0 | 0 | 30 | 0 | |
| 3 |  | B. Sheets | 7 | 10 | 8/15/2005 |  MIL | @ |  COL | L | 1 | 15.00 | 0 | 0 | 0 | 6.0 | 13 | 10 | 1 | 0 | 0 | 0 | 0 | 31 | 0 |
| 4 |  | R. Ortiz | 7 | 10 | 5/21/2000 |  SFG | @ | MIL | W | 1 | 13.50 | 0 | 0 | 0 | 6.2 | 8 | 10 | 2 | 3 | 1 | 0 | 0 | 32 | 2 |
| 5 |  | J. Shields | 6 | 10 | 9/6/2013 |  KCR | vs |  DET | L | 1 | 24.55 | 0 | 0 | 0 | 3.2 | 14 | 10 | 0 | 2 | 0 | 0 | 0 | 26 | 1 |
| 6 |  | J. Garcia | 6 | 11 | 5/28/2011 |  STL | @ | COL | L | 1 | 29.70 | 0 | 0 | 0 | 3.1 | 11 | 12 | 1 | 4 | 0 | 0 | 0 | 26 | 0 |
| 7 |  | B. Backe | 6 | 11 | 8/16/2008 |  HOU | vs |  ARI | L | 1 | 17.47 | 0 | 0 | 0 | 5.2 | 9 | 11 | 3 | 5 | 0 | 0 | 0 | 29 | 0 |
| 8 |  | N. Robertson | 6 | 10 | 8/24/2006 | DET | vs |  CWS | L | 1 | 13.50 | 0 | 0 | 0 | 6.2 | 9 | 10 | 3 | 2 | 0 | 0 | 1 | 30 | 0 |
| 9 |  | O. Perez | 6 | 10 | 8/26/2003 |  LAD | @ | HOU | L | 1 | 19.29 | 0 | 0 | 0 | 4.2 | 10 | 10 | 2 | 3 | 0 | 0 | 0 | 27 | 0 |
| 10 |  | R. Rupe | 6 | 10 | 8/16/2001 |  TBD | @ |  NYY | L | 1 | 15.88 | 0 | 0 | 0 | 5.2 | 9 | 11 | 2 | 3 | 1 | 0 | 0 | 30 | 0 |
| 11 |  | P. Astacio | 6 | 10 | 7/13/2000 | COL | vs |  CIN | L | 1 | 15.00 | 0 | 0 | 0 | 6.0 | 8 | 10 | 3 | 3 | 1 | 0 | 1 | 30 | 1 |
| 12 | | J. Lima | 6 | 12 | 4/27/2000 | HOU | vs |  CHC | L | 1 | 21.60 | 0 | 0 | 0 | 5.0 | 13 | 12 | 5 | 3 | 0 | 0 | 0 | 31 | 1 |
| 13 |  | P. Blackburn | 5 | 10 | 7/24/2022 |  OAK | vs |  TEX | L | 1 | 20.77 | 0 | 0 | 0 | 4.1 | 10 | 10 | 2 | 2 | 2 | 0 | 0 | 26 | 0 |
| 14 |  | J. Ross | 5 | 10 | 4/19/2021 |  WSH | vs | STL | L | 1 | 20.77 | 0 | 0 | 0 | 4.1 | 8 | 10 | 4 | 3 | 1 | 0 | 1 | 24 | 0 |
| 15 | | G. Márquez | 5 | 10 | 8/20/2020 | COL | vs |  HOU | L | 1 | 18.00 | 0 | 0 | 0 | 5.0 | 10 | 10 | 1 | 2 | 0 | 0 | 0 | 27 | 0 |
| 16 |  | Y. Darvish | 5 | 10 | 7/26/2017 | TEX | vs |  MIA | L | 1 | 24.55 | 0 | 0 | 0 | 3.2 | 9 | 10 | 2 | 2 | 0 | 0 | 0 | 22 | 0 |
| 17 |  | M. Scherzer | 5 | 10 | 6/17/2014 | DET | vs | KCR | L | 1 | 22.50 | 0 | 0 | 0 | 4.0 | 10 | 10 | 2 | 1 | 1 | 0 | 0 | 24 | 0 |
| 18 |  | R. Hernandez | 5 | 10 | 4/1/2011 |  CLE | vs | CWS | L | 1 | 30.00 | 0 | 0 | 0 | 3.0 | 11 | 10 | 2 | 1 | 0 | 0 | 0 | 21 | 0 |
| 19 | | M. Parra | 5 | 10 | 6/2/2009 | MIL | @ |  FLA | L | 1 | 22.50 | 0 | 0 | 0 | 4.0 | 11 | 10 | 2 | 2 | 0 | 0 | 0 | 25 | 2 |
| 20 |  | O. Hernandez | 5 | 11 | 8/15/2006 |  NYM | @ |  PHI | L | 1 | 24.75 | 0 | 0 | 0 | 4.0 | 10 | 11 | 2 | 4 | 0 | 0 | 1 | 26 | 0 |
| 21 |  | P. Martinez | 5 | 10 | 4/12/2003 | BOS | vs |  BAL | L | 1 | 20.77 | 0 | 0 | 0 | 4.1 | 9 | 10 | 0 | 4 | 0 | 0 | 0 | 25 | 0 |
| 22 | | J. Cabrera | 5 | 11 | 8/24/2002 | MIL | vs |  PIT | L | 1 | 18.56 | 0 | 0 | 0 | 5.1 | 11 | 11 | 1 | 2 | 2 | 0 | 0 | 30 | 0 |
| 23 | | S. Chacon | 5 | 11 | 7/8/2001 | COL | vs |  ANA | L | 1 | 19.80 | 0 | 0 | 0 | 5.0 | 12 | 11 | 5 | 1 | 0 | 0 | 0 | 27 | 0 |
| 24 | | S. Trachsel | 5 | 10 | 4/7/2001 | NYM | @ |  MON | L | 1 | 18.00 | 0 | 0 | 0 | 5.0 | 9 | 10 | 3 | 4 | 0 | 0 | 0 | 27 | 0 |
| 25 |  | T. Hatch | 4 | 10 | 7/2/2022 | TOR | vs |  TBR | L | 1 | 19.29 | 0 | 0 | 0 | 4.2 | 12 | 10 | 3 | 2 | 1 | 0 | 0 | 26 | 0 |
Some of the information used here was obtained free of charge from Retrosheet.
Guardians 
BAL 
MIL 
Mariners 
MIA 
