most strikeouts in a game by a pitcher against the guardians

6 pitchers are tied for fanning the most hitters in a game against the Cleveland Indians, with 15 strikeouts. The first three are Zack Greinke on August 25, 2009, Mark Langston on June 25, 1986 and Jorge Rubio on October 2, 1966.

Interpreted as:
most strikeouts in a regular-season game by a pitcher against the guardians
NAMESODATETMOPPDECGSERACGSHOSVIPHERRHRBBHBPGFIBBTBFWP
1Zack Greinke
Z. Greinke
15
8/25/2009
vs
W
1
2.25
0
0
0
8.0
5
2
2
1
1
0
0
0
29
0
2Mark Langston
M. Langston
15
6/25/1986
vs
W
1
0.00
1
0
0
9.0
3
0
1
0
5
0
0
0
35
0
3Jorge Rubio
J. Rubio
15
10/2/1966
vs
W
1
0.00
1
1
0
9.0
5
0
0
0
2
0
0
0
33
0
4Mickey McDermott
M. McDermott
15
7/28/1951
vs
W
1
2.25
1
0
0
16.0
11
4
4
0
1
1
0
0
61
0
5Ed Walsh
E. Walsh
15
10/2/1908
@
L
1
1
0
0
8.0
4
1
0
1
0
0
29
1
6Rube Waddell
R. Waddell
15
8/19/1904
vs
L
1
0.82
1
0
0
11.0
8
1
2
0
4
0
0
44
0
7Corbin Burnes
C. Burnes
14
9/11/2021
@
W
1
0.00
0
0
0
8.0
0
0
0
0
1
0
0
0
25
0
8Jose Fernandez
J. Fernandez
14
8/2/2013
vs
W
1
0.00
0
0
0
8.0
3
0
0
0
1
0
0
0
28
0
9Johan Santana
J. Santana
14
6/2/2005
vs
1
3.38
0
0
0
8.0
4
3
3
2
1
0
0
0
29
0
10Pedro Martinez
P. Martinez
14
9/15/1999
@
1
2.57
0
0
0
7.0
8
2
2
0
1
0
0
0
30
1
11Mark Langston
M. Langston
14
9/28/1986
vs
1
3.86
0
0
0
7.0
7
3
3
0
3
0
0
0
31
0
12Al Downing
A. Downing
14
7/6/1963
@
W
1
4.70
0
0
0
7.2
6
4
4
2
5
0
0
0
33
0
13Bob Turley
B. Turley
14
4/21/1954
vs
L
1
2.00
1
0
0
9.0
2
2
2
1
4
0
0
0
34
0
14Rube Waddell
R. Waddell
14
8/11/1904
@
W
1
0.69
1
0
0
13.0
5
1
1
0
4
2
0
47
0
15Rube Waddell
R. Waddell
14
6/12/1903
vs
W
1
0.00
1
0
0
14.0
6
0
1
0
2
1
0
51
0
16Tarik Skubal
T. Skubal
13
5/25/2025
vs
W
1
0.00
1
1
0
9.0
2
0
0
0
0
1
0
0
29
0
17Justin Verlander
J. Verlander
13
7/30/2019
@
W
1
0.00
0
0
0
7.0
2
0
0
0
0
0
0
0
23
0
18Doug Fister
D. Fister
13
9/5/2011
@
W
1
1.13
0
0
0
8.0
4
1
2
1
1
1
0
0
31
0
19Randy Johnson
R. Johnson
13
7/7/1995
@
W
1
2.00
1
0
0
9.0
8
2
3
0
0
0
0
0
34
0
20Gaylord Perry
G. Perry
13
7/22/1975
vs
W
1
0.00
1
1
0
9.0
2
0
0
0
1
0
0
0
29
0
21Rudy May
R. May
13
9/29/1974
@
W
1
0.00
1
1
0
9.0
4
0
0
0
2
0
0
0
31
0
22Jim Palmer
J. Palmer
13
7/1/1971
@
1
2.25
0
0
0
8.0
7
2
2
0
5
0
0
1
34
0
23Dave McNally
D. McNally
13
4/7/1970
@
W
1
2.00
1
0
0
9.0
4
2
2
1
3
0
0
0
33
0
24Mike Kilkenny
M. Kilkenny
13
9/17/1969
vs
W
1
0.00
1
1
0
9.0
5
0
0
0
5
0
0
0
37
0
25Juan Pizarro
J. Pizarro
13
8/25/1961
vs
W
1
2.00
1
0
0
9.0
6
2
2
1
6
0
0
1
39
0
Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.

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Schedule
DATEMATCHUPTIME (ET)
Thu
4/9
@
7:40 PM
Fri
4/10
@
7:40 PM
Sat
4/11
@
4:10 PM
Sun
4/12
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Tue
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Last Game
KCR Royals

5 - 7

2

Final

10

CLE Guardians

8 - 5

Wed 8 Apr 2026

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MLB 2026 Pitching Leaders

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MLB 2026 Standings

NL EastWLPCTGB
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NL WestWLPCTGB
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AL EastWLPCTGB
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AL CentralWLPCTGB
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1.5
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3.5
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AL WestWLPCTGB
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MLB 2026 Scores & Schedule

Scores

DATEMATCHUPSCORE
Tue
3/24
@
7-0
Wed
3/25
@
7-11
Wed
3/25
@
2-14
Wed
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@
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Wed
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Schedule

DATEMATCHUPTIME (ET)
Thu
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@
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Thu
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@
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Thu
4/9
@
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Fri
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Fri
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