most strikeouts in a game by a pitcher against the guardians

6 pitchers are tied for fanning the most hitters in a game against the Cleveland Indians, with 15 strikeouts. The first three are Zack Greinke on August 25, 2009, Mark Langston on June 25, 1986 and Jorge Rubio on October 2, 1966.

Interpreted as:

most strikeouts in a regular-season game by a pitcher against the guardians

	NAME	SO	DATE	TM		OPP	DEC	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Zack Greinke Z. Greinke	15	8/25/2009	KCR	vs	CLE	W	1	2.25	0	0	0	8.0	5	2	2	1	1	0	0	0	29	0
2	Mark Langston M. Langston	15	6/25/1986	SEA	vs	CLE	W	1	0.00	1	0	0	9.0	3	0	1	0	5	0	0	0	35	0
3	Jorge Rubio J. Rubio	15	10/2/1966	CAL	vs	CLE	W	1	0.00	1	1	0	9.0	5	0	0	0	2	0	0	0	33	0
4	Mickey McDermott M. McDermott	15	7/28/1951	BSA	vs	CLE	W	1	2.25	1	0	0	16.0	11	4	4	0	1	1	0	0	61	0
5	Ed Walsh E. Walsh	15	10/2/1908	CWS	@	CLE	L	1		1	0	0	8.0	4		1	0	1	0	0		29	1
6	Rube Waddell R. Waddell	15	8/19/1904	PHA	vs	CLE	L	1	0.82	1	0	0	11.0	8	1	2	0	4	0	0		44	0
7	Corbin Burnes C. Burnes	14	9/11/2021	MIL	@	CLE	W	1	0.00	0	0	0	8.0	0	0	0	0	1	0	0	0	25	0
8	Jose Fernandez J. Fernandez	14	8/2/2013	MIA	vs	CLE	W	1	0.00	0	0	0	8.0	3	0	0	0	1	0	0	0	28	0
9	Johan Santana J. Santana	14	6/2/2005	MIN	vs	CLE		1	3.38	0	0	0	8.0	4	3	3	2	1	0	0	0	29	0
10	Pedro Martinez P. Martinez	14	9/15/1999	BOS	@	CLE		1	2.57	0	0	0	7.0	8	2	2	0	1	0	0	0	30	1
11	Mark Langston M. Langston	14	9/28/1986	SEA	vs	CLE		1	3.86	0	0	0	7.0	7	3	3	0	3	0	0	0	31	0
12	Al Downing A. Downing	14	7/6/1963	NYY	@	CLE	W	1	4.70	0	0	0	7.2	6	4	4	2	5	0	0	0	33	0
13	Bob Turley B. Turley	14	4/21/1954	BAL	vs	CLE	L	1	2.00	1	0	0	9.0	2	2	2	1	4	0	0	0	34	0
14	Rube Waddell R. Waddell	14	8/11/1904	PHA	@	CLE	W	1	0.69	1	0	0	13.0	5	1	1	0	4	2	0		47	0
15	Rube Waddell R. Waddell	14	6/12/1903	PHA	vs	CLE	W	1	0.00	1	0	0	14.0	6	0	1	0	2	1	0		51	0
16	Tarik Skubal T. Skubal	13	5/25/2025	DET	vs	CLE	W	1	0.00	1	1	0	9.0	2	0	0	0	0	1	0	0	29	0
17	Justin Verlander J. Verlander	13	7/30/2019	HOU	@	CLE	W	1	0.00	0	0	0	7.0	2	0	0	0	0	0	0	0	23	0
18	Doug Fister D. Fister	13	9/5/2011	DET	@	CLE	W	1	1.13	0	0	0	8.0	4	1	2	1	1	1	0	0	31	0
19	Randy Johnson R. Johnson	13	7/7/1995	SEA	@	CLE	W	1	2.00	1	0	0	9.0	8	2	3	0	0	0	0	0	34	0
20	Gaylord Perry G. Perry	13	7/22/1975	TEX	vs	CLE	W	1	0.00	1	1	0	9.0	2	0	0	0	1	0	0	0	29	0
21	Rudy May R. May	13	9/29/1974	NYY	@	CLE	W	1	0.00	1	1	0	9.0	4	0	0	0	2	0	0	0	31	0
22	Jim Palmer J. Palmer	13	7/1/1971	BAL	@	CLE		1	2.25	0	0	0	8.0	7	2	2	0	5	0	0	1	34	0
23	Dave McNally D. McNally	13	4/7/1970	BAL	@	CLE	W	1	2.00	1	0	0	9.0	4	2	2	1	3	0	0	0	33	0
24	Mike Kilkenny M. Kilkenny	13	9/17/1969	DET	vs	CLE	W	1	0.00	1	1	0	9.0	5	0	0	0	5	0	0	0	37	0
25	Juan Pizarro J. Pizarro	13	8/25/1961	CWS	vs	CLE	W	1	2.00	1	0	0	9.0	6	2	2	1	6	0	0	1	39	0