The Seattle Mariners had their most strikeouts in a game on September 25, 2012 and on April 29, 1986, with 20 strikeouts.

Interpreted as:

most strikeouts in a regular-season game mariners

	TEAM	SO	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mariners	20	9/25/2012	SEA	@	LAA	L 4-5	37	4	11	5	0	2	4	2	0	0	0	40	22	7	1	0	0	0	.297	.333	.595	.928
2	Mariners	20	4/29/1986	SEA	@	BOS	L 1-3	30	1	3	0	0	1	1	0	0	0	0	30	6	1	0	0	0	0	.100	.100	.200	.300
3	Mariners	19	4/8/2025	SEA	vs	HOU	L 1-2	40	1	5	2	0	0	1	3	1	4	0	44	7	2	0	0	0	1	.125	.205	.175	.380
4	Mariners	19	6/13/2024	SEA	vs	CWS	L 2-3	33	2	3	1	0	2	2	2	0	0	0	35	10	3	0	0	0	0	.091	.143	.303	.446
5	Mariners	19	4/29/2023	SEA	@	TOR	L 0-1	35	0	6	0	0	0	0	2	0	1	0	37	6	0	0	0	0	0	.171	.216	.171	.388
6	Mariners	19	8/30/2015	SEA	@	CWS	L 5-6	44	5	12	1	1	2	5	3	0	0	1	47	21	4	0	0	1	1	.273	.319	.477	.796
7	Mariners	19	6/5/2013	SEA	vs	CWS	L 5-7	58	5	16	2	0	1	5	7	0	2	0	65	21	3	0	0	0	4	.276	.354	.362	.716
8	Mariners	19	4/17/2013	SEA	vs	DET	L 1-2	48	1	11	3	0	0	1	4	0	0	0	53	14	3	1	0	0	3	.229	.288	.292	.580
9	Mariners	18	4/20/2025	SEA	@	TOR	W 8-3	39	8	12	1	0	3	8	2	1	0	1	42	22	4	0	0	0	0	.308	.357	.564	.921
10	Mariners	18	6/18/2023	SEA	vs	CWS	W 5-1	29	5	5	1	1	0	5	4	0	1	0	33	8	2	0	0	0	0	.172	.273	.276	.549
11	Mariners	18	9/20/2020	SEA	vs	SDP	L 4-7	36	4	5	2	0	1	4	5	0	0	0	42	10	3	0	1	0	1	.139	.238	.278	.516
12	Mariners	18	9/24/2019	SEA	vs	HOU	L 0-3	31	0	4	1	0	0	0	1	0	0	0	32	5	1	0	0	0	0	.129	.156	.161	.318
13	Mariners	18	9/18/2012	SEA	vs	BAL	L 2-4	65	2	12	4	0	1	2	6	0	1	0	72	19	5	1	0	1	0	.185	.254	.292	.546
14	Mariners	18	7/26/2011	SEA	@	NYY	L 1-4	28	1	1	0	0	0	1	3	0	0	0	31	1	0	0	0	0	0	.036	.129	.036	.165
15	Mariners	18	4/19/1986	SEA	vs	OAK	L 2-7	32	2	5	1	0	0	2	5	0	0	0	37	6	1	0	0	0	0	.156	.270	.188	.458
16	Mariners	18	4/24/1978	SEA	@	CAL	W 6-5	45	6	11	2	0	1	6	8	0	5	0	55	16	3	1	1	1	0	.244	.352	.356	.707
17	Mariners	17	8/27/2024	SEA	vs	TBR	L 2-3	31	2	5	0	0	0	1	4	0	2	1	35	5	0	0	0	0	0	.161	.257	.161	.418
18	Mariners	17	9/16/2020	SEA	vs	SFG	L 3-9	31	3	6	1	0	0	3	8	2	0	1	41	7	1	0	0	0	1	.194	.390	.226	.616
19	Mariners	17	9/8/2019	SEA	@	HOU	L 1-21	28	1	1	0	0	1	1	0	0	0	0	28	4	1	0	0	0	0	.036	.036	.143	.179
20	Mariners	17	8/9/2016	SEA	vs	DET	W 6-5	56	6	16	2	1	1	6	4	0	0	1	61	23	4	0	1	0	2	.286	.328	.411	.739
21	Mariners	17	7/20/2012	SEA	@	TBR	L 3-4	48	3	5	1	1	1	3	3	1	1	1	52	11	3	0	0	0	0	.104	.173	.229	.402
22	Mariners	17	9/13/2011	SEA	vs	NYY	L 2-3	31	2	6	2	0	0	2	4	2	2	1	38	8	2	0	1	1	0	.194	.316	.258	.574
23	Mariners	16	9/12/2024	SEA	vs	TEX	L 4-5	32	4	6	0	0	1	3	5	0	4	0	38	9	1	1	0	0	0	.188	.297	.281	.579
24	Mariners	16	9/27/2023	SEA	vs	HOU	L 3-8	34	3	8	1	0	1	3	9	0	2	0	43	12	2	0	0	0	1	.235	.395	.353	.748
25	Mariners	16	8/26/2022	SEA	vs	CLE	W 3-2	33	3	8	1	0	0	3	2	0	0	1	39	9	1	2	2	1	2	.242	.270	.273	.543