5 players are tied for the most strikeouts in a game this season, with 5 strikeouts. The first three are Tyler Stephenson on May 6, Nick Castellanos on April 10 and Jose Altuve on April 3.

Interpreted as:

most strikeouts by a player in one regular-season game this year

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Tyler Stephenson T. Stephenson	5	5/6/2025	CIN	@	ATL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
2	Nick Castellanos N. Castellanos	5	4/10/2025	PHI	@	ATL	5	1	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
3	Jose Altuve J. Altuve	5	4/3/2025	HOU	@	MIN	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
4	Dylan Crews D. Crews	5	3/29/2025	WSH	vs	PHI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
5	Jackson Chourio J. Chourio	5	3/27/2025	MIL	@	NYY	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Rhys Hoskins R. Hoskins	4	6/9/2025	MIL	vs	ATL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
7	Riley Greene R. Greene	4	6/7/2025	DET	vs	CHC	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
8	Salvador Perez S. Perez	4	6/7/2025	KCR	@	CWS	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
9	Will Wilson W. Wilson	4	6/7/2025	CLE	vs	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
10	Seth Brown S. Brown	4	6/7/2025	ATH	vs	BAL	4	0	0	0	0	0	0	1	0	0	0	5	0	0	0	0	0	0
11	Jesús Sánchez J. Sánchez	4	6/6/2025	MIA	@	TBR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
12	Harrison Bader H. Bader	4	6/6/2025	MIN	vs	TOR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
13	Andrew McCutchen A. McCutchen	4	6/5/2025	PIT	vs	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
14	Eugenio Suárez E. Suárez	4	6/4/2025	AZ	@	ATL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
15	Gabriel Arias G. Arias	4	6/4/2025	CLE	@	NYY	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
16	Ke'Bryan Hayes K. Hayes	4	5/30/2025	PIT	@	SDP	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
17	Riley Greene R. Greene	4	5/28/2025	DET	vs	SFG	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
18	Lawrence Butler L. Butler	4	5/28/2025	ATH	@	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
19	Denzel Clarke D. Clarke	4	5/28/2025	ATH	@	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
20	Jarren Duran J. Duran	4	5/27/2025	BOS	@	MIL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
21	Tyler Soderstrom T. Soderstrom	4	5/27/2025	ATH	@	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
22	Luis Campusano L. Campusano	4	5/25/2025	SDP	@	ATL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
23	Bobby Witt Jr. B. Witt Jr.	4	5/24/2025	KCR	@	MIN	5	0	1	0	0	0	0	0	0	2	0	5	1	0	0	0	0	0
24	Rhys Hoskins R. Hoskins	4	5/24/2025	MIL	@	PIT	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
25	Cam Smith C. Smith	4	5/21/2025	HOU	@	TBR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0