Between the 1920 and 1929 seasons, Babe Ruth had the most strikeouts, with 795 strikeouts.

Interpreted as:

most strikeouts by a player in the 1920s

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Babe Ruth B. Ruth	795	1,399	4,884	1,365	1,734	314	82	467	1,338	1,240	27	88	6,224	3,613	863	73	.355	.488	.740	1.228	1701	932.6	.535	206	884.9
2	High Pockets Kelly H. Pockets Kelly	571	1,351	5,186	736	1,569	304	69	134	923	339	26	62	5,684	2,413	507	133	.303	.348	.465	.814	817	111.8	.371	114	102.1
3	Bob Meusel B. Meusel	556	1,294	5,032	764	1,565	338	87	146	1,009	349	20	134	5,544	2,515	571	143	.311	.358	.500	.858	872	184.9	.389	119	141.2
4	Jimmy Dykes J. Dykes	498	1,247	4,440	676	1,285	276	59	70	539	460	72	46	5,125	1,889	405	153	.289	.365	.425	.791	724	89.7	.368	103	19.7
5	Aaron Ward A. Ward	439	1,004	3,519	450	952	155	54	50	442	331	25	35	4,024	1,365	259	149	.271	.338	.388	.725	475	-22.2	.340	89	-61.6
6	Rogers Hornsby R. Hornsby	431	1,430	5,451	1,195	2,085	405	115	250	1,153	753	24	74	6,389	3,470	770	161	.382	.460	.637	1.096	1531	739.3	.490	186	714.6
7	Marty McManus M. McManus	414	1,257	4,649	740	1,360	273	73	91	734	442	23	86	5,274	2,052	437	160	.293	.357	.441	.798	742	80.9	.367	100	2.6
8	Bernie Friberg B. Friberg	412	1,005	3,270	427	911	129	36	33	379	366	15	49	3,770	1,211	198	119	.279	.354	.370	.724	455	-15.9	.343	87	-62.1
9	Cy Williams C. Williams	401	1,239	4,274	721	1,327	200	47	202	715	490	43	58	4,883	2,227	449	76	.310	.387	.521	.908	864	264.4	.414	129	179
10	Hack Wilson H. Wilson	388	755	2,747	530	864	154	50	137	604	360	18	39	3,202	1,529	341	77	.315	.397	.557	.954	611	211.3	.429	146	194.9
11	Lou Gehrig L. Gehrig	351	767	2,746	631	919	206	72	146	635	480	15	30	3,321	1,707	424	80	.335	.436	.622	1.058	743	327.2	.470	170	313.1
12	George Grantham G. Grantham	343	926	3,190	583	983	187	64	66	496	463	17	114	3,786	1,496	317	116	.308	.399	.469	.868	635	163.7	.401	126	129.7
13	Kiki Cuyler K. Cuyler	341	797	3,033	618	1,005	169	81	70	493	297	45	210	3,465	1,546	320	90	.331	.399	.510	.909	620	185.3	.414	133	154.7
14	Heinie Sand H. Sand	340	848	3,033	457	781	145	32	18	251	382	15	21	3,529	1,044	195	99	.258	.343	.344	.688	385	-51.2	.329	75	-114
15	Jim Bottomley J. Bottomley	337	1,062	4,134	711	1,354	261	104	146	885	406	24	40	4,690	2,261	511	126	.328	.391	.547	.938	869	282.6	.422	140	248.9
16	Johnny Mostil J. Mostil	330	962	3,474	614	1,045	207	80	23	371	414	70	175	4,061	1,481	310	103	.301	.386	.426	.813	610	105.1	.380	113	74.1
17	Harry Heilmann H. Heilmann	324	1,417	5,285	962	1,924	397	101	142	1,131	615	25	70	6,115	2,949	640	190	.364	.433	.558	.991	1266	508.8	.450	153	441
18	Joe Dugan J. Dugan	315	1,171	4,461	604	1,301	241	41	38	487	220	31	24	4,856	1,738	320	144	.292	.329	.390	.719	550	-48.6	.334	85	-96.8
19	Lu Blue L. Blue	311	1,230	4,516	897	1,324	248	87	39	548	820	33	109	5,514	1,863	374	145	.293	.405	.413	.818	862	171.2	.386	115	112
20	Bucky Harris B. Harris	306	1,251	4,700	721	1,290	221	64	9	504	470	98	167	5,516	1,666	294	248	.274	.353	.354	.707	640	-39.6	.337	89	-79
21	Travis Jackson T. Jackson	299	899	3,284	474	969	162	47	81	492	239	4	45	3,633	1,468	290	106	.295	.344	.447	.791	495	40.2	.362	106	26.3
22	Rabbit Maranville R. Maranville	298	1,155	4,407	589	1,199	181	99	6	424	353	11	124	4,887	1,596	286	116	.272	.328	.362	.690	513	-93.6	.323	82	-118.7
23	Ray Powell R. Powell	298	609	2,309	343	642	88	46	29	193	227	14	21	2,592	909	163	42	.278	.346	.394	.740	322	6	.346	102	9.1
24	Hod Ford H. Ford	297	1,174	4,094	417	1,098	171	44	15	437	303	21	19	4,563	1,402	230	145	.268	.322	.342	.664	443	-124.5	.313	76	-142.9
25	Ross Youngs R. Youngs	289	953	3,638	664	1,187	187	75	39	523	454	24	118	4,212	1,641	301	96	.326	.405	.451	.856	693	174.5	.399	133	171.8