The Baltimore Orioles had their most strikeouts in a game against the Red Sox on May 8, 2019, with 22 strikeouts.

Interpreted as:

most strikeouts in a regular-season game on orioles all-time

	TEAM	SO	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	22	5/8/2019	BAL	vs	BOS	L 1-2	41	1	5	2	0	0	1	0	2	2	0	43	7	2	0	0	0	0	.122	.163	.171	.334
2	Orioles	21	9/12/1962	BAL	vs	WSH	L 1-2	58	1	10	4	0	0	1	4	0	1	0	62	14	4	0	0	0	0	.172	.226	.241	.467
3	Orioles	20	5/5/2018	BAL	@	OAK	L 0-2	41	0	7	3	0	0	0	5	1	1	2	47	10	3	0	0	1	0	.171	.277	.244	.520
4	Orioles	19	5/24/2016	BAL	@	HOU	L 2-3	47	2	8	2	0	2	2	5	0	1	0	52	16	4	0	0	1	1	.170	.250	.340	.590
5	Browns	19	7/25/1913	SLA	@	WSH	N 8-8	58	8	15	2	1	0		3	1	2		62	19	3	0				.259	.306	.328	.634
6	Orioles	18	8/12/2018	BAL	vs	BOS	L 1-4	31	1	5	0	0	0	1	5	0	0	0	37	5	0	0	1	0	0	.161	.270	.161	.432
7	Orioles	18	10/1/2017	BAL	@	TBR	L 0-6	31	0	3	0	0	0	0	0	0	0	0	31	3	0	0	0	0	0	.097	.097	.097	.194
8	Orioles	18	7/6/2016	BAL	@	LAD	W 6-4	53	6	13	3	0	2	5	7	1	0	0	61	22	5	0	0	1	1	.245	.344	.415	.759
9	Orioles	18	5/25/2016	BAL	@	HOU	L 3-4	38	3	11	5	0	0	2	4	0	1	0	42	16	5	0	0	2	0	.289	.357	.421	.778
10	Orioles	18	5/10/2015	BAL	@	NYY	L 2-6	35	2	8	3	0	1	2	0	0	0	0	35	14	4	0	0	0	0	.229	.229	.400	.629
11	Orioles	17	5/6/2025	BAL	@	MIN	L 1-9	30	1	3	1	0	0	1	3	0	0	0	33	4	1	0	0	0	0	.100	.182	.133	.315
12	Orioles	17	5/14/2023	BAL	vs	PIT	L 0-4	35	0	8	1	0	0	0	0	1	1	0	36	9	1	0	0	0	0	.229	.250	.257	.507
13	Orioles	17	9/16/2021	BAL	vs	NYY	W 3-2	37	3	10	0	0	1	2	2	0	0	1	39	13	1	0	0	1	0	.270	.308	.351	.659
14	Orioles	17	4/7/2021	BAL	@	NYY	W 4-3	37	4	4	0	0	2	3	2	0	0	0	40	10	2	1	0	0	0	.108	.154	.270	.424
15	Orioles	17	7/25/2019	BAL	@	LAA	W 10-8	65	10	18	2	0	2	10	4	0	5	0	70	26	4	0	1	0	1	.277	.314	.400	.714
16	Orioles	17	6/7/2019	BAL	@	HOU	L 3-4	39	3	5	1	0	1	3	0	1	0	0	40	9	2	0	0	0	0	.128	.150	.231	.381
17	Orioles	17	5/30/2008	BAL	vs	BOS	L 2-5	48	2	8	1	0	1	1	7	0	3	0	55	12	2	0	0	3	0	.167	.273	.250	.523
18	Orioles	17	9/21/1998	BAL	@	TOR	L 1-3	35	1	8	2	0	0	1	3	0	1	0	38	10	2	0	0	0	0	.229	.289	.286	.575
19	Orioles	17	5/26/1995	BAL	@	SEA	L 3-8	38	3	11	3	0	1	3	3	0	0	0	41	17	4	0	0	0	0	.289	.341	.447	.789
20	Orioles	17	8/25/1968	BAL	vs	BOS	W 3-2	60	3	13	3	1	0	3	12	1	0	0	77	18	4	3	1	3	1	.217	.351	.300	.651
21	Orioles	16	5/26/2024	BAL	@	CWS	W 4-1	32	4	6	2	0	2	4	3	0	2	0	36	14	4	0	1	0	0	.188	.250	.438	.688
22	Orioles	16	7/9/2023	BAL	@	MIN	W 15-2	44	15	17	1	1	6	15	4	1	0	0	49	38	8	0	0	0	0	.386	.449	.864	1.313
23	Orioles	16	6/6/2023	BAL	@	MIL	L 3-4	38	3	8	2	0	2	3	1	0	0	0	39	16	4	0	0	1	0	.211	.231	.421	.652
24	Orioles	16	5/6/2023	BAL	@	ATL	L 4-5	35	4	8	3	0	0	4	1	0	1	1	36	11	3	0	0	0	0	.229	.250	.314	.564
25	Orioles	16	6/26/2022	BAL	@	CWS	L 3-4	35	3	7	1	0	1	3	2	0	0	0	38	11	2	0	1	0	0	.200	.237	.314	.551