Since 2021, the Los Angeles Dodgers have the most wins by a team, with 452 wins.

Interpreted as:

most team regular-season wins in the MLB since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	452	257	.638	709	24,109	3,777	6,152	1,272	110	1,031	3,642	2,699	329	5,982	444	95	27,429	10,737	2,413	53	239	133	425	.255	.335	.445	.781
2	Astros	412	295	.583	707	24,090	3,409	6,228	1,208	71	908	3,280	2,268	291	5,275	366	107	26,898	10,302	2,187	52	197	94	559	.259	.327	.428	.755
3	Braves	409	297	.579	706	23,952	3,469	6,068	1,215	75	1,065	3,334	2,242	275	6,202	382	108	26,691	10,628	2,355	50	172	84	467	.253	.322	.444	.766
4	Yankees	404	303	.571	707	23,526	3,328	5,649	1,009	60	1,029	3,171	2,713	258	6,144	395	121	26,737	9,865	2,098	48	192	110	568	.240	.323	.419	.742
5	Brewers	400	311	.563	711	23,751	3,256	5,676	1,101	89	813	3,105	2,567	297	6,312	606	140	26,847	9,394	2,003	73	159	93	488	.239	.319	.396	.714
6	Rays	396	312	.559	708	23,822	3,248	5,796	1,204	103	800	3,084	2,274	318	6,344	605	190	26,603	9,606	2,107	30	159	63	404	.243	.316	.403	.719
7	Phillies	391	317	.552	708	23,991	3,350	6,049	1,185	115	887	3,214	2,317	272	6,089	527	114	26,848	10,125	2,187	84	184	101	472	.252	.323	.422	.745
8	Mariners	385	322	.545	707	23,565	3,085	5,447	1,043	58	871	2,961	2,469	419	6,645	459	127	26,661	9,219	1,972	45	163	56	448	.231	.313	.391	.704
9	Giants	380	329	.536	709	23,740	3,137	5,660	1,136	95	833	3,002	2,422	312	6,382	291	81	26,735	9,485	2,064	80	181	98	499	.238	.315	.400	.714
10	Mets	380	329	.536	709	23,595	3,162	5,794	1,104	94	838	3,026	2,263	443	5,791	386	93	26,550	9,600	2,036	86	163	85	509	.246	.321	.407	.728
11	Padres	378	329	.535	707	23,737	3,192	5,881	1,166	78	781	3,048	2,455	254	5,448	459	133	26,749	9,546	2,025	118	185	106	521	.248	.323	.402	.725
12	Blue Jays	377	331	.532	708	24,017	3,289	6,157	1,266	72	866	3,158	2,267	274	5,416	354	114	26,771	10,165	2,204	49	164	70	548	.256	.325	.423	.749
13	Guardians	372	334	.527	706	23,636	3,022	5,771	1,142	106	700	2,864	2,030	310	5,317	571	140	26,254	9,225	1,948	80	198	133	473	.244	.310	.390	.700
14	Cardinals	370	338	.523	708	23,902	3,149	5,955	1,184	80	823	3,018	2,260	319	5,676	412	117	26,753	9,768	2,087	81	191	79	469	.249	.320	.409	.729
15	Red Sox	359	353	.504	712	24,401	3,390	6,267	1,452	92	825	3,236	2,186	294	6,289	404	124	27,106	10,378	2,369	45	180	103	491	.257	.323	.425	.749
16	Twins	353	355	.499	708	23,905	3,198	5,844	1,210	89	881	3,047	2,280	366	6,213	275	85	26,772	9,875	2,180	40	181	60	526	.244	.318	.413	.731
17	Orioles	350	357	.495	707	23,878	3,153	5,837	1,198	109	847	3,023	2,092	283	6,090	404	116	26,492	9,794	2,154	55	184	54	431	.244	.311	.410	.721
18	Cubs	349	359	.493	708	23,760	3,266	5,810	1,127	131	816	3,115	2,352	339	6,270	559	152	26,729	9,647	2,074	97	181	71	476	.245	.319	.406	.725
19	Tigers	347	363	.489	710	23,772	2,907	5,630	1,055	150	689	2,792	2,060	229	6,418	317	102	26,291	9,052	1,894	48	182	43	455	.237	.302	.381	.683
20	Reds	334	377	.470	711	23,737	3,196	5,730	1,162	104	814	3,052	2,275	396	6,374	548	170	26,659	9,542	2,080	87	164	49	480	.241	.316	.402	.718
21	Diamondbacks	328	380	.463	708	23,836	3,317	5,860	1,232	148	778	3,150	2,393	285	5,764	482	113	26,872	9,722	2,158	141	217	73	470	.246	.319	.408	.727
22	Rangers	325	384	.458	709	23,913	3,101	5,769	1,066	83	834	2,965	2,134	233	6,023	465	128	26,487	9,503	1,983	45	162	62	424	.241	.308	.397	.705
23	Angels	314	395	.443	709	23,736	2,975	5,630	1,045	102	864	2,841	2,070	303	6,464	386	144	26,336	9,471	2,011	81	146	100	472	.237	.305	.399	.704
24	Royals	313	396	.441	709	23,755	2,941	5,851	1,121	157	670	2,823	1,865	247	5,526	573	167	26,198	9,296	1,948	102	229	58	419	.246	.305	.391	.696
25	Marlins	305	403	.431	708	23,801	2,752	5,758	1,075	97	669	2,622	1,905	256	6,171	487	141	26,214	9,034	1,841	93	159	75	530	.242	.303	.380	.683