Warren Spahn has the most career wins versus the Giants, with 56 wins.

Interpreted as:

most regular-season wins as a starting by a player qb vs giants

	NAME	W	GS	L	W%	G	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Warren Spahn W. Spahn	56	108	43	.566	119	3.24	416	67	6	3	861.1	788	310	334	100	241	8	9		3,531	11	4.35	2.52	1.73	1.04	11.8	6.8	1.19	.249	3.49	8.23
2	Grover Alexander G. Alexander	39	86	43	.476	99	3.20	261	56	8	4	723.0	769		329	33	171	11	8		3,019	8	3.25	2.13	1.53	0.41	8.6	5.7	1.30	.289	4.10	9.57
3	Mordecai Brown M. Brown	36	58	25	.590	78	0.41	212	46	7	4	533.1	461		179	5	125	19	17			14	3.58	2.11	1.70	0.08		6.0	1.10	.263	3.02	7.78
4	Don Drysdale D. Drysdale	34	73	31	.523	77	2.92	358	28	7	1	543.1	479	176	201	48	138	18	4	13	2,222	8	5.93	2.29	2.59	0.80	16.1	6.2	1.14	.260	3.33	7.93
5	Eppa Rixey E. Rixey	33	68	36	.478	89	3.57	162	35	2	2	546.2	608	217	265	21	109	10	16		2,282	8	2.67	1.79	1.49	0.35	7.1	4.8	1.31	.296	4.36	10.01
6	Lew Burdette L. Burdette	32	53	17	.653	76	3.57	148	25	5	1	429.0	407	170	189	61	103	9	8		1,761	3	3.10	2.16	1.44	1.28	8.4	5.8	1.19	.240	3.97	8.54
7	Lon Warneke L. Warneke	32	57	24	.571	73	3.55	176	31	10	1	453.2	445	179	201	36	128	7	10		1,906	4	3.49	2.54	1.38	0.71	9.2	6.7	1.26	.262	3.99	8.83
8	Burleigh Grimes B. Grimes	32	73	38	.457	85	3.59	208	49	2	2	604.2	635		307	26	196	13	10		2,608	18	3.10	2.92	1.06	0.39	8.0	7.5	1.37	.281	4.57	9.45
9	Greg Maddux G. Maddux	31	55	15	.674	55	2.90	254	5	0	0	363.1	312	117	138	25	79	12	0	14	1,471	9	6.29	1.96	3.22	0.62	17.3	5.4	1.08	.261	3.42	7.73
10	Larry French L. French	31	68	26	.544	92	3.30	204	35	5	3	557.0	595	204	242	46	144	3	10		2,396	8	3.30	2.33	1.42	0.74	8.5	6.0	1.33	.275	3.91	9.61
11	Dazzy Vance D. Vance	31	59	21	.596	68	3.41	340	37	5	0	487.2	473	185	211	31	129	7	4		2,028	10	6.27	2.38	2.64	0.57	16.8	6.4	1.23	.291	3.89	8.73
12	Babe Adams B. Adams	31	62	25	.554	81	2.40	172	37	4	2	533.1	501		195	16	71	11	14		2,130	7	2.90	1.20	2.42	0.27	8.1	3.3	1.07	.261	3.29	8.45
13	Don Sutton D. Sutton	30	65	25	.545	66	3.78	356	21	9	0	459.0	412	193	210	42	145	8	1	11	1,921	13	6.98	2.84	2.46	0.82	18.5	7.5	1.21	.270	4.12	8.08
14	Phil Niekro P. Niekro	30	62	16	.652	73	3.07	301	24	4	3	477.1	436	163	188	36	154	9	6	9	1,973	22	5.68	2.90	1.95	0.68	15.3	7.8	1.24	.272	3.54	8.22
15	Bucky Walters B. Walters	30	56	23	.566	64	3.55	146	36	7	3	453.1	460	179	210	22	173	3	6		1,931	9	2.90	3.43	0.84	0.44	7.6	9.0	1.40	.276	4.17	9.13
16	Steve Carlton S. Carlton	29	58	19	.604	60	3.20	351	19	6	0	419.0	374	149	169	35	155	1	1	11	1,725	11	7.54	3.33	2.26	0.75	20.3	9.0	1.26	.287	3.63	8.03
17	Robin Roberts R. Roberts	29	69	33	.468	77	2.77	268	38	3	4	556.0	497	171	202	48	101	5	6		2,239	7	4.34	1.63	2.65	0.78	12.0	4.5	1.08	.247	3.27	8.04
18	Curt Simmons C. Simmons	29	68	31	.483	81	3.77	240	26	6	0	493.2	454	207	231	42	177	7	5		2,078	6	4.38	3.23	1.36	0.77	11.5	8.5	1.28	.256	4.21	8.28
19	Lee Meadows L. Meadows	29	61	24	.547	72	4.16	154	34	2	0	454.0	490		244	22	132	14	4			9	3.05	2.62	1.17	0.44		6.8	1.37	.290	4.84	9.71
20	Clayton Kershaw C. Kershaw	27	59	16	.628	61	2.00	413	6	5	0	404.1	300	90	101	29	70	4	0	7	1,551	15	9.19	1.56	5.90	0.65	26.6	4.5	0.92	.262	2.25	6.68
21	Bill Lee B. Lee	27	58	23	.540	72	3.76	134	26	7	4	440.1	478	184	210	36	138	4	6		1,906	9	2.74	2.82	0.97	0.74	7.0	7.2	1.40	.277	4.29	9.77
22	Curt Davis C. Davis	27	43	16	.628	65	3.55	88	19	3	5	350.0	362	138	152	30	71	12	15		1,459	6	2.26	1.83	1.24	0.77	6.0	4.9	1.24	.264	3.91	9.31
23	Charlie Root C. Root	27	42	22	.551	91	3.20	186	21	1	7	422.0	416	150	171	39	94	6	32		1,750	3	3.97	2.00	1.98	0.83	10.6	5.4	1.21	.265	3.65	8.87
24	Bob Gibson B. Gibson	26	50	22	.542	57	2.99	336	27	6	0	406.1	346	135	153	36	128	11	4	13	1,673	7	7.44	2.84	2.63	0.80	20.1	7.7	1.17	.267	3.39	7.66
25	Tom Seaver T. Seaver	25	45	13	.658	45	2.85	257	16	5	0	325.2	250	103	115	32	116	4	0	10	1,319	7	7.10	3.21	2.22	0.88	19.5	8.8	1.12	.240	3.18	6.91