Between the 2001 and 2004 seasons, the New York Yankees had the most wins by a team, with 400 wins.

Interpreted as:

most regular-season wins by a team in MLB 2001 to 2004

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	400	245	.620	647	22,310	3,475	6,029	1,188	66	898	3,339	2,513	297	4,230	443	157	25,404	10,043	2,152	115	169	180	580	.270	.350	.450	.800
2	Athletics	392	256	.605	648	22,356	3,245	5,862	1,266	89	769	3,101	2,413	270	3,988	209	85	25,322	9,613	2,124	92	191	186	519	.262	.339	.430	.769
3	Braves	386	260	.598	647	22,233	3,147	5,971	1,168	117	751	3,004	2,183	207	4,158	315	139	25,092	9,626	2,036	271	198	216	526	.269	.337	.433	.770
4	Cardinals	380	268	.586	648	22,182	3,332	6,068	1,220	114	784	3,170	2,199	256	4,053	370	156	25,186	9,868	2,118	326	223	260	505	.274	.343	.445	.788
5	Giants	376	270	.582	647	22,111	3,187	5,898	1,199	137	796	3,044	2,539	227	3,905	227	123	25,376	9,759	2,132	303	196	414	516	.267	.346	.441	.787
6	Red Sox	368	279	.569	647	22,734	3,541	6,333	1,408	127	835	3,393	2,344	264	4,207	282	128	25,641	10,500	2,370	86	213	189	520	.279	.350	.462	.812
7	Mariners	365	283	.563	648	22,532	3,234	6,221	1,161	122	596	3,069	2,321	220	4,039	529	179	25,479	9,414	1,879	170	236	199	496	.276	.346	.418	.764
8	Twins	361	286	.558	647	22,420	3,120	6,093	1,304	143	677	2,938	1,992	247	4,181	435	219	24,988	9,714	2,124	147	182	150	514	.272	.335	.433	.769
9	Dodgers	356	292	.549	648	22,047	2,806	5,641	1,036	111	688	2,682	1,890	243	4,079	367	156	24,595	8,963	1,835	264	151	183	497	.256	.320	.407	.726
10	Astros	356	292	.549	648	22,082	3,204	5,865	1,206	127	753	3,043	2,317	290	4,259	290	136	25,166	9,584	2,086	294	183	207	525	.266	.341	.434	.775
11	Angels	343	305	.529	648	22,391	3,114	6,126	1,156	128	622	2,943	1,882	280	3,586	505	210	24,962	9,404	1,906	201	208	161	462	.274	.335	.420	.755
12	Phillies	338	309	.522	647	22,206	3,087	5,812	1,248	120	710	2,943	2,487	209	4,508	429	146	25,330	9,430	2,078	244	184	238	476	.262	.339	.425	.764
13	White Sox	333	315	.514	648	21,987	3,310	5,864	1,176	96	893	3,178	2,093	222	3,896	353	170	24,701	9,911	2,165	212	187	100	490	.267	.334	.451	.785
14	Cubs	332	316	.512	648	22,049	2,996	5,699	1,137	114	801	2,870	2,143	198	4,584	269	116	24,929	9,467	2,052	353	186	210	504	.258	.327	.429	.757
15	Marlins	329	319	.508	648	22,014	2,910	5,800	1,172	138	617	2,752	2,079	243	4,221	512	230	24,789	9,099	1,927	278	175	193	503	.263	.331	.413	.745
16	Diamondbacks	325	323	.502	648	22,217	2,969	5,833	1,165	161	660	2,837	2,202	187	4,096	292	154	25,036	9,300	1,986	252	178	232	498	.263	.332	.419	.750
17	Indians	313	335	.483	648	22,271	3,193	5,886	1,190	118	746	3,054	2,191	265	4,147	311	194	25,092	9,550	2,054	181	184	133	546	.264	.335	.429	.764
18	Blue Jays	311	336	.481	647	22,436	3,193	5,964	1,239	141	717	3,032	2,051	288	4,400	322	129	25,055	9,636	2,097	82	198	142	526	.266	.332	.429	.762
19	Rangers	305	343	.471	648	22,582	3,419	6,074	1,227	120	942	3,274	2,090	273	4,299	293	127	25,269	10,367	2,289	120	204	144	466	.269	.335	.459	.795
20	Expos	301	347	.465	648	21,769	2,751	5,558	1,190	116	588	2,604	2,071	186	4,090	428	192	24,530	8,744	1,894	344	160	253	532	.255	.323	.402	.725
21	Padres	296	352	.457	648	22,101	2,897	5,735	1,077	119	564	2,743	2,356	184	4,318	328	152	25,014	8,742	1,760	176	197	158	523	.259	.333	.396	.729
22	Mets	294	352	.455	646	21,828	2,658	5,463	1,062	84	616	2,523	2,032	243	4,300	330	144	24,521	8,541	1,762	274	144	201	531	.250	.319	.391	.710
23	Reds	289	359	.446	648	22,080	2,888	5,579	1,127	92	721	2,750	2,174	291	5,021	376	165	24,964	9,053	1,940	282	137	185	476	.253	.326	.410	.736
24	Rockies	288	360	.444	648	22,297	3,387	6,174	1,268	167	765	3,209	2,195	223	4,385	342	177	25,172	10,071	2,200	282	175	187	521	.277	.345	.452	.797
25	Pirates	281	365	.435	646	21,792	2,731	5,553	1,061	129	608	2,587	1,948	322	4,330	328	199	24,504	8,696	1,798	286	156	170	440	.255	.323	.399	.722