Between the 2005 and 2008 seasons, the Los Angeles Angels had the most wins by a team, with 378 wins.

Interpreted as:

most regular-season wins by a team in MLB 2005 to 2008

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Angels	378	270	.583	648	22,327	3,114	6,123	1,185	107	588	2,960	1,921	163	3,632	577	217	24,756	9,286	1,880	138	207	207	537	.274	.333	.416	.749
2	Yankees	375	273	.579	648	22,564	3,573	6,328	1,201	89	820	3,436	2,458	303	4,048	464	141	25,644	10,167	2,110	134	185	152	551	.280	.356	.451	.807
3	Red Sox	372	276	.574	648	22,430	3,442	6,215	1,371	105	730	3,276	2,660	247	4,210	312	94	25,666	9,986	2,206	94	235	193	564	.277	.357	.445	.802
4	Mets	357	291	.551	648	22,274	3,159	5,924	1,170	138	724	2,995	2,201	203	4,151	637	157	25,166	9,542	2,032	296	192	247	460	.266	.335	.428	.763
5	Phillies	354	294	.546	648	22,426	3,363	5,977	1,193	153	810	3,195	2,492	308	4,608	482	96	25,663	9,906	2,156	255	182	285	455	.267	.345	.442	.787
6	White Sox	350	299	.539	649	22,180	3,113	5,835	1,089	76	861	3,004	2,009	252	4,223	375	194	24,795	9,659	2,026	166	188	126	535	.263	.329	.435	.764
7	Indians	348	300	.537	648	22,375	3,276	6,057	1,332	106	752	3,155	2,209	291	4,712	266	129	25,220	9,857	2,190	144	201	175	492	.271	.341	.441	.782
8	Cardinals	347	300	.536	647	22,225	3,090	6,076	1,141	92	669	2,936	2,148	219	3,763	271	133	25,052	9,408	1,902	287	173	240	560	.273	.341	.423	.764
9	Twins	346	303	.533	649	22,329	3,036	6,081	1,115	151	506	2,860	2,016	193	3,668	417	158	24,911	9,016	1,772	159	214	184	609	.272	.335	.404	.739
10	Blue Jays	336	312	.519	648	22,216	3,051	5,958	1,302	122	626	2,913	2,054	258	3,843	274	117	24,858	9,382	2,050	118	212	115	569	.268	.334	.422	.757
11	Athletics	332	315	.513	647	22,155	2,930	5,653	1,141	81	626	2,795	2,425	199	4,140	232	83	25,058	8,834	1,848	92	187	102	586	.255	.332	.399	.730
12	Astros	330	317	.510	648	22,039	2,863	5,696	1,133	111	669	2,746	2,062	252	4,207	373	165	24,838	9,058	1,913	316	169	179	496	.258	.327	.411	.738
13	Brewers	329	319	.508	648	21,970	3,007	5,666	1,262	111	784	2,880	2,084	300	4,735	354	141	24,773	9,502	2,157	238	181	207	479	.258	.328	.432	.761
14	Tigers	328	320	.506	648	22,642	3,253	6,250	1,222	176	748	3,100	1,860	198	4,301	292	129	25,027	10,068	2,146	150	177	119	529	.276	.334	.445	.779
15	Cubs	327	320	.505	647	22,402	3,026	6,084	1,263	118	695	2,873	1,950	183	4,088	359	155	24,957	9,668	2,076	266	156	169	527	.272	.333	.432	.764
16	Braves	325	323	.502	648	22,362	3,181	6,039	1,264	123	712	3,053	2,212	188	4,425	266	124	25,210	9,685	2,099	277	171	203	557	.270	.338	.433	.772
17	Dodgers	325	323	.502	648	22,181	2,940	5,925	1,138	143	568	2,805	2,196	202	3,949	449	177	24,998	9,053	1,849	245	174	194	548	.267	.336	.408	.744
18	Diamondbacks	325	323	.502	648	22,002	2,901	5,630	1,226	152	681	2,783	2,229	228	4,457	310	103	24,913	9,203	2,059	255	199	185	494	.256	.328	.418	.746
19	Padres	322	327	.496	649	22,258	2,793	5,679	1,153	135	616	2,672	2,239	191	4,569	313	116	25,127	8,950	1,904	254	185	158	491	.255	.326	.402	.728
20	Marlins	316	331	.488	647	22,130	3,035	5,854	1,257	140	719	2,881	2,073	292	4,870	387	158	24,954	9,548	2,116	279	180	212	458	.265	.333	.431	.765
21	Rangers	313	335	.483	648	22,658	3,417	6,178	1,342	123	816	3,268	2,098	207	4,604	289	89	25,262	10,214	2,281	121	178	125	517	.273	.337	.451	.788
22	Rockies	307	342	.473	649	22,352	3,160	6,034	1,228	152	638	3,002	2,262	239	4,572	391	150	25,394	9,480	2,018	380	161	187	503	.270	.341	.424	.765
23	Reds	299	349	.461	649	22,152	3,056	5,719	1,188	74	830	2,926	2,321	237	4,733	378	134	25,128	9,545	2,092	254	164	195	479	.258	.333	.431	.764
24	Mariners	296	352	.457	648	22,504	2,920	6,075	1,124	118	579	2,745	1,676	211	3,711	379	146	24,692	9,172	1,821	144	157	175	523	.270	.324	.408	.732
25	Giants	294	353	.454	647	22,015	2,718	5,704	1,174	152	516	2,575	1,909	189	3,743	356	139	24,569	8,730	1,842	295	161	221	564	.259	.321	.397	.718