Between the 2005 and 2009 seasons, the New York Yankees had the most wins by a team, with 478 wins.

Interpreted as:

most regular-season wins by a team in MLB 2005 to 2009

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	478	332	.590	810	28,224	4,488	7,932	1,526	110	1,064	4,317	3,121	357	5,062	575	169	32,091	12,870	2,700	165	224	187	695	.281	.357	.456	.813
2	Angels	475	335	.586	810	27,949	3,997	7,727	1,478	140	761	3,801	2,468	204	4,686	725	280	31,061	11,768	2,379	181	259	239	665	.276	.337	.421	.758
3	Red Sox	467	343	.577	810	27,973	4,314	7,710	1,706	130	942	4,098	3,319	317	5,330	438	133	32,008	12,502	2,778	113	286	232	701	.276	.356	.447	.803
4	Phillies	447	363	.552	810	28,004	4,183	7,416	1,505	188	1,034	3,983	3,081	379	5,763	601	124	32,001	12,399	2,727	310	227	332	545	.265	.343	.443	.786
5	Cardinals	438	371	.541	809	27,690	3,820	7,512	1,435	121	829	3,630	2,676	280	4,804	346	164	31,217	11,676	2,385	355	216	313	687	.271	.339	.422	.761
6	Twins	433	379	.533	812	27,937	3,853	7,620	1,386	191	678	3,630	2,601	238	4,689	502	190	31,257	11,422	2,255	210	271	230	756	.273	.337	.409	.746
7	White Sox	429	382	.529	811	27,643	3,837	7,245	1,335	96	1,045	3,699	2,543	314	5,245	488	243	30,927	11,907	2,476	200	227	151	674	.262	.329	.431	.760
8	Mets	427	383	.527	810	27,727	3,830	7,396	1,465	187	819	3,626	2,727	239	5,079	759	201	31,324	11,692	2,471	384	247	296	604	.267	.335	.422	.757
9	Dodgers	420	390	.519	810	27,773	3,720	7,436	1,416	182	713	3,544	2,803	265	5,017	565	225	31,382	11,355	2,311	323	218	270	689	.268	.338	.409	.747
10	Tigers	414	397	.510	811	28,182	3,996	7,693	1,467	211	931	3,818	2,400	259	5,415	364	162	31,260	12,375	2,609	203	216	149	660	.273	.333	.439	.772
11	Indians	413	397	.510	810	27,943	4,049	7,525	1,646	134	913	3,885	2,791	372	5,923	350	160	31,540	12,178	2,693	183	251	195	632	.269	.341	.436	.777
12	Braves	411	399	.507	810	27,901	3,916	7,498	1,564	143	861	3,753	2,814	240	5,489	324	150	31,545	11,931	2,568	372	218	257	699	.269	.338	.428	.766
13	Blue Jays	411	399	.507	810	27,912	3,849	7,474	1,641	135	835	3,679	2,602	303	4,871	347	140	31,220	11,890	2,611	142	261	138	699	.268	.334	.426	.760
14	Cubs	410	398	.507	808	27,888	3,733	7,482	1,556	147	856	3,551	2,542	242	5,273	415	189	31,201	11,900	2,559	331	198	213	661	.268	.333	.427	.759
15	Brewers	409	401	.505	810	27,480	3,792	7,113	1,543	148	966	3,637	2,694	371	5,966	422	178	31,069	11,850	2,657	296	228	251	607	.259	.331	.431	.762
16	Athletics	407	402	.503	809	27,739	3,689	7,117	1,448	102	761	3,518	2,952	249	5,186	365	131	31,304	11,052	2,311	123	241	118	716	.257	.331	.398	.729
17	Astros	404	405	.499	810	27,475	3,506	7,111	1,403	143	811	3,362	2,510	295	5,197	486	209	30,876	11,233	2,357	382	214	216	649	.259	.325	.409	.734
18	Marlins	403	406	.498	809	27,702	3,807	7,347	1,553	165	878	3,608	2,641	355	6,096	462	193	31,266	11,864	2,596	349	219	258	568	.265	.335	.428	.763
19	Rangers	400	410	.494	810	28,184	4,201	7,614	1,638	150	1,040	4,016	2,570	244	5,857	438	125	31,388	12,672	2,828	161	229	148	614	.270	.334	.450	.784
20	Rockies	399	412	.492	811	27,750	3,964	7,442	1,528	202	828	3,762	2,922	286	5,849	497	205	31,635	11,858	2,558	456	221	227	614	.268	.342	.427	.769
21	Padres	397	414	.490	811	27,683	3,431	6,994	1,418	166	757	3,277	2,825	248	5,751	395	145	31,305	11,015	2,341	328	221	210	622	.253	.325	.398	.723
22	Diamondbacks	395	415	.488	810	27,567	3,621	7,038	1,533	197	854	3,469	2,800	265	5,755	412	143	31,181	11,527	2,584	309	240	232	587	.255	.327	.418	.745
23	Giants	382	427	.472	809	27,508	3,375	7,115	1,449	195	638	3,187	2,301	239	4,901	434	167	30,626	10,868	2,282	362	216	262	679	.259	.319	.395	.714
24	Mariners	381	429	.470	810	28,047	3,560	7,505	1,404	137	739	3,358	2,097	260	4,804	468	179	30,805	11,400	2,280	200	201	214	647	.268	.322	.406	.729
25	Reds	377	433	.465	811	27,614	3,729	7,068	1,468	99	988	3,563	2,852	290	5,862	474	174	31,315	11,698	2,555	354	205	232	582	.256	.330	.424	.753