Since 2021, the Los Angeles Dodgers have the most wins by a team, with 451 wins.

Interpreted as:

most regular-season wins by a team in MLB since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	451	257	.637	708	24,074	3,771	6,145	1,269	110	1,029	3,636	2,695	329	5,970	444	95	27,390	10,721	2,408	53	239	132	425	.255	.335	.445	.781
2	Astros	411	295	.582	706	24,058	3,406	6,223	1,207	71	906	3,277	2,267	291	5,267	365	107	26,865	10,290	2,184	52	197	94	558	.259	.327	.428	.755
3	Braves	409	296	.580	705	23,918	3,466	6,062	1,215	75	1,064	3,332	2,241	275	6,197	382	108	26,656	10,619	2,354	50	172	84	467	.253	.322	.444	.766
4	Yankees	403	303	.571	706	23,497	3,325	5,644	1,009	60	1,027	3,168	2,710	258	6,138	395	120	26,705	9,854	2,096	48	192	110	568	.240	.323	.419	.742
5	Brewers	399	310	.563	709	23,679	3,245	5,658	1,099	89	809	3,094	2,562	297	6,296	605	140	26,769	9,362	1,997	72	159	93	488	.239	.319	.395	.714
6	Rays	395	312	.559	707	23,790	3,243	5,788	1,204	103	798	3,081	2,272	318	6,335	603	190	26,569	9,592	2,105	30	159	63	404	.243	.316	.403	.719
7	Phillies	390	317	.552	707	23,953	3,342	6,038	1,185	115	884	3,207	2,313	271	6,079	527	114	26,805	10,105	2,184	84	184	101	472	.252	.323	.422	.745
8	Mariners	385	321	.545	706	23,533	3,084	5,440	1,043	58	870	2,960	2,468	419	6,637	459	127	26,628	9,209	1,971	45	163	56	446	.231	.313	.391	.705
9	Giants	380	328	.537	708	23,706	3,135	5,654	1,134	95	832	3,000	2,419	312	6,378	291	81	26,697	9,474	2,061	79	181	98	498	.239	.315	.400	.715
10	Mets	380	328	.537	708	23,557	3,157	5,786	1,102	94	837	3,021	2,260	443	5,785	386	93	26,509	9,587	2,033	86	163	85	508	.246	.321	.407	.728
11	Padres	377	329	.534	706	23,699	3,189	5,871	1,166	78	781	3,045	2,449	253	5,440	458	133	26,704	9,536	2,025	118	185	106	520	.248	.322	.402	.725
12	Blue Jays	377	330	.533	707	23,986	3,286	6,152	1,266	72	864	3,155	2,261	274	5,409	354	114	26,734	10,154	2,202	49	164	70	547	.256	.326	.423	.749
13	Guardians	372	333	.528	705	23,603	3,020	5,764	1,141	106	700	2,862	2,028	310	5,308	568	140	26,219	9,217	1,947	80	198	133	473	.244	.310	.391	.700
14	Cardinals	370	337	.523	707	23,863	3,142	5,943	1,181	80	821	3,012	2,255	319	5,668	412	117	26,709	9,747	2,082	81	191	79	469	.249	.320	.408	.728
15	Red Sox	358	352	.504	710	24,331	3,376	6,245	1,447	92	823	3,222	2,174	292	6,273	402	124	27,020	10,345	2,362	45	178	102	486	.257	.323	.425	.748
16	Twins	352	355	.498	707	23,866	3,188	5,832	1,208	89	878	3,038	2,275	364	6,199	275	85	26,726	9,852	2,175	40	181	60	526	.244	.317	.413	.730
17	Orioles	349	357	.494	706	23,842	3,148	5,824	1,197	109	846	3,018	2,090	283	6,086	404	116	26,453	9,777	2,152	55	183	54	428	.244	.311	.410	.721
18	Cubs	348	359	.492	707	23,726	3,258	5,801	1,125	130	815	3,107	2,347	339	6,261	556	152	26,687	9,631	2,070	97	178	71	476	.244	.319	.406	.725
19	Tigers	347	362	.489	709	23,739	2,906	5,623	1,054	150	689	2,791	2,056	229	6,408	317	102	26,254	9,044	1,893	48	182	43	454	.237	.302	.381	.683
20	Reds	333	376	.470	709	23,677	3,191	5,718	1,157	104	812	3,047	2,265	396	6,357	546	169	26,588	9,519	2,073	87	163	48	479	.242	.316	.402	.718
21	Diamondbacks	327	380	.463	707	23,801	3,309	5,849	1,231	148	774	3,142	2,389	285	5,757	481	112	26,833	9,698	2,153	141	217	73	469	.246	.319	.407	.727
22	Rangers	325	383	.459	708	23,882	3,100	5,765	1,066	83	834	2,964	2,133	233	6,011	465	128	26,455	9,499	1,983	45	162	62	424	.241	.308	.398	.706
23	Angels	313	394	.443	707	23,663	2,962	5,610	1,040	101	863	2,829	2,063	302	6,450	385	143	26,253	9,441	2,004	80	145	100	470	.237	.305	.399	.704
24	Royals	312	396	.441	708	23,716	2,931	5,838	1,120	157	668	2,813	1,863	247	5,521	572	167	26,156	9,276	1,945	101	229	58	419	.246	.305	.391	.696
25	Marlins	305	401	.432	706	23,740	2,748	5,747	1,073	97	669	2,618	1,901	255	6,162	485	141	26,147	9,021	1,839	92	159	75	528	.242	.303	.380	.683