Between the 2006 and 2010 seasons, the New York Yankees had the most wins by a team, with 478 wins.

Interpreted as:

most regular-season wins by an MLB team 2006 to 2010

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	478	332	.590	810	28,167	4,461	7,865	1,542	126	1,036	4,293	3,146	357	5,209	594	172	32,065	12,767	2,704	170	225	182	694	.279	.356	.453	.810
2	Red Sox	461	349	.569	810	27,993	4,222	7,642	1,725	131	954	4,017	3,253	317	5,426	461	138	31,960	12,491	2,810	128	269	241	696	.273	.352	.446	.798
3	Angels	460	350	.568	810	27,813	3,917	7,570	1,476	129	769	3,731	2,487	227	4,908	668	275	30,964	11,611	2,374	180	257	216	665	.272	.334	.417	.752
4	Phillies	456	354	.563	810	28,043	4,148	7,373	1,513	187	1,033	3,959	3,002	386	5,744	593	118	31,947	12,359	2,733	292	224	325	558	.263	.340	.441	.781
5	Twins	444	368	.547	812	27,941	3,946	7,700	1,435	200	686	3,735	2,675	218	4,678	468	174	31,322	11,593	2,321	206	282	226	760	.276	.340	.415	.755
6	Dodgers	429	381	.530	810	27,766	3,702	7,430	1,402	190	684	3,512	2,795	244	5,107	599	240	31,391	11,264	2,276	351	235	297	673	.268	.337	.406	.743
7	Cardinals	424	385	.524	809	27,694	3,751	7,474	1,433	113	809	3,562	2,683	268	4,884	342	169	31,210	11,560	2,355	344	221	331	684	.270	.338	.417	.755
8	Tigers	424	387	.523	811	28,223	4,024	7,687	1,492	198	915	3,857	2,562	247	5,524	367	164	31,437	12,320	2,605	200	205	175	641	.272	.336	.437	.773
9	Mets	423	387	.522	810	27,687	3,764	7,336	1,452	195	772	3,568	2,743	237	5,099	736	205	31,322	11,494	2,419	389	266	300	602	.265	.333	.415	.749
10	White Sox	418	393	.515	811	27,598	3,848	7,262	1,345	94	1,022	3,696	2,575	314	5,165	511	250	30,900	11,861	2,461	197	216	147	700	.263	.331	.430	.760
11	Blue Jays	416	394	.514	810	27,826	3,829	7,358	1,653	117	956	3,676	2,587	269	5,080	333	125	31,058	12,113	2,726	137	239	145	687	.264	.330	.435	.766
12	Rockies	415	396	.512	811	27,738	3,994	7,417	1,518	222	851	3,799	2,998	269	6,020	531	214	31,663	11,932	2,591	424	234	244	592	.267	.342	.430	.772
13	Braves	412	398	.509	810	27,878	3,885	7,456	1,568	131	816	3,719	2,914	246	5,545	295	147	31,611	11,734	2,515	366	207	251	689	.267	.340	.421	.761
14	Rangers	411	399	.507	810	28,103	4,123	7,642	1,595	146	942	3,922	2,586	241	5,731	494	158	31,386	12,355	2,683	205	251	165	620	.272	.336	.440	.775
15	Cubs	406	402	.502	808	27,816	3,715	7,390	1,531	151	811	3,535	2,602	242	5,589	405	181	31,181	11,656	2,493	322	199	196	654	.266	.332	.419	.751
16	Padres	405	406	.499	811	27,615	3,412	6,916	1,385	151	759	3,252	2,763	249	5,957	420	151	31,181	10,880	2,295	335	219	236	606	.250	.322	.394	.716
17	Brewers	405	405	.500	810	27,638	3,816	7,171	1,509	162	973	3,658	2,709	379	6,020	424	170	31,216	11,923	2,644	265	225	231	585	.259	.331	.431	.763
18	Rays	404	406	.499	810	27,509	3,850	7,115	1,434	179	916	3,669	2,926	274	6,175	773	258	31,114	11,655	2,529	156	249	153	527	.259	.333	.424	.757
19	Athletics	400	409	.494	809	27,560	3,580	7,037	1,414	112	715	3,398	2,942	244	5,428	490	147	31,145	10,820	2,241	147	252	112	697	.255	.330	.393	.722
20	Marlins	400	409	.494	809	27,731	3,809	7,251	1,541	170	902	3,616	2,643	343	6,553	458	181	31,247	11,838	2,613	318	212	239	531	.261	.331	.427	.758
21	Giants	399	410	.493	809	27,534	3,423	7,099	1,434	199	672	3,230	2,357	240	5,099	418	164	30,691	10,947	2,305	347	213	289	690	.258	.320	.398	.717
22	Reds	395	415	.488	810	27,628	3,699	7,130	1,426	114	954	3,540	2,763	296	5,777	495	194	31,280	11,646	2,494	377	216	224	579	.258	.330	.422	.751
23	Astros	391	418	.483	809	27,465	3,424	7,059	1,374	136	758	3,285	2,444	256	5,185	471	201	30,741	10,979	2,268	375	201	200	663	.257	.321	.400	.721
24	Indians	389	421	.480	810	27,821	3,905	7,365	1,599	124	834	3,726	2,833	382	6,014	379	157	31,450	11,714	2,557	180	234	196	622	.265	.338	.421	.759
25	Diamondbacks	383	427	.473	810	27,490	3,638	6,985	1,543	204	843	3,490	2,783	249	6,190	431	158	31,037	11,465	2,590	279	236	226	568	.254	.326	.417	.743