Between the 2000 and 2009 seasons, Andy Pettitte won the most games, with 148 wins.

Interpreted as:

most regular-season wins for a pitcher 2000s

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Andy Pettitte A. Pettitte	148	89	.624	303	300	3.90	1,441	11	3	0	1882.0	1,975	815	917	165	545	32	1	29	8,008	31	6.89	2.61	2.64	0.79	18.0	6.8	1.34	.311	4.39	87	3.61	81	9.44	179.8
2	Randy Johnson R. Johnson	143	78	.647	287	281	3.34	2,182	32	12	0	1885.1	1,616	699	790	212	484	89	3	22	7,686	34	10.42	2.31	4.51	1.01	28.4	6.3	1.11	.298	3.77	75	3.12	70	7.71	275.2
3	Jamie Moyer J. Moyer	140	94	.598	321	315	4.23	1,178	11	3	0	1980.1	2,025	931	989	270	550	80	2	31	8,414	21	5.35	2.50	2.14	1.23	14.0	6.5	1.30	.277	4.49	97	4.61	105	9.20	-46.8
4	Roy Halladay R. Halladay	139	69	.668	275	267	3.40	1,400	47	14	0	1883.1	1,832	712	790	151	374	52	4	21	7,712	37	6.69	1.79	3.74	0.72	18.2	4.8	1.17	.293	3.78	74	3.31	74	8.75	243.9
5	Roy Oswalt R. Oswalt	137	70	.662	283	271	3.23	1,473	18	6	0	1803.1	1,756	647	695	154	412	66	5	30	7,455	21	7.35	2.06	3.58	0.77	19.8	5.5	1.20	.299	3.47	75	3.34	76	8.76	208.1
6	Tim Hudson T. Hudson	137	76	.643	290	289	3.50	1,270	21	11	0	1923.1	1,837	749	818	156	570	71	0	59	8,024	52	5.94	2.67	2.23	0.73	15.8	7.1	1.25	.282	3.83	79	3.81	86	8.60	135.6
7	CC Sabathia	136	81	.627	288	288	3.62	1,590	28	11	0	1889.1	1,738	760	827	168	590	59	0	22	7,834	36	7.57	2.81	2.69	0.80	20.3	7.5	1.23	.289	3.94	82	3.58	82	8.28	166.2
8	Mark Buehrle M. Buehrle	135	97	.582	326	301	3.80	1,188	24	8	0	2061.0	2,143	871	973	236	470	52	6	35	8,562	17	5.19	2.05	2.53	1.03	13.9	5.5	1.27	.288	4.25	82	4.16	90	9.36	106
9	Greg Maddux G. Maddux	134	101	.570	308	308	3.70	1,211	16	7	0	1939.2	1,965	797	877	196	308	57	0	59	7,964	24	5.62	1.43	3.93	0.91	15.2	3.9	1.17	.286	4.07	86	3.70	85	9.12	147.3
10	Mike Mussina M. Mussina	134	87	.606	283	282	3.87	1,488	18	9	0	1790.2	1,801	769	828	194	364	41	0	14	7,379	35	7.48	1.83	4.09	0.98	20.2	4.9	1.21	.304	4.16	86	3.50	78	9.05	192.8
11	Barry Zito B. Zito	133	106	.556	321	320	3.84	1,501	10	4	0	1999.0	1,775	852	929	209	826	81	0	36	8,484	36	6.76	3.72	1.82	0.94	17.7	9.7	1.30	.267	4.18	88	4.29	98	7.99	23.4
12	Derek Lowe D. Lowe	130	99	.568	410	270	3.81	1,177	9	3	66	1833.2	1,863	776	885	149	519	54	115	39	7,746	32	5.78	2.55	2.27	0.73	15.2	6.7	1.30	.293	4.34	86	3.79	87	9.14	114.6
13	Livan Hernandez L. Hernandez	129	124	.510	332	332	4.46	1,335	36	7	0	2201.1	2,450	1,091	1,165	250	720	57	0	57	9,533	29	5.46	2.94	1.85	1.02	14.0	7.6	1.44	.307	4.76	104	4.40	102	10.02	-19.5
14	Javier Vazquez J. Vazquez	128	116	.525	328	327	3.98	2,001	23	6	0	2163.0	2,101	957	1,025	269	528	64	0	40	9,023	59	8.33	2.20	3.79	1.12	22.2	5.9	1.22	.297	4.26	89	3.66	82	8.74	195
15	Johan Santana J. Santana	122	60	.670	310	234	3.12	1,733	9	6	1	1709.2	1,430	592	641	187	473	34	23	10	6,946	65	9.12	2.49	3.66	0.98	24.9	6.8	1.11	.275	3.37	70	3.37	78	7.53	181.5
16	Tom Glavine T. Glavine	118	87	.576	283	283	3.77	948	11	7	0	1753.2	1,769	734	790	178	600	30	0	59	7,431	10	4.87	3.08	1.58	0.91	12.8	8.1	1.35	.280	4.05	89	4.39	101	9.08	-6.9
17	Bartolo Colon B. Colon	117	82	.588	246	245	4.07	1,222	23	5	0	1573.2	1,571	712	777	205	510	31	0	19	6,660	26	6.99	2.92	2.40	1.17	18.3	7.7	1.32	.291	4.44	90	4.22	94	8.98	45
18	Jon Garland J. Garland	117	102	.534	311	288	4.42	960	10	6	1	1829.1	1,944	898	992	228	593	53	9	27	7,827	40	4.72	2.92	1.62	1.12	12.3	7.6	1.39	.286	4.88	97	4.71	103	9.56	-22.8
19	Curt Schilling C. Schilling	117	63	.650	243	221	3.54	1,545	26	7	9	1569.1	1,515	618	630	194	257	21	21	9	6,368	23	8.86	1.47	6.01	1.11	24.3	4.0	1.13	.304	3.61	78	3.23	73	8.69	204.8
20	Kevin Millwood K. Millwood	115	103	.528	307	305	4.18	1,398	15	4	0	1860.2	1,923	865	937	201	578	56	0	35	7,982	41	6.76	2.80	2.42	0.97	17.5	7.2	1.34	.300	4.53	94	4.00	90	9.30	87.6
21	Jeff Suppan J. Suppan	115	110	.511	324	321	4.55	1,079	11	4	0	1965.2	2,168	993	1,093	260	683	83	0	47	8,608	70	4.94	3.13	1.58	1.19	12.5	7.9	1.45	.293	5.00	102	4.87	110	9.93	-92
22	Pedro Martinez P. Martinez	112	50	.691	227	227	3.01	1,620	18	6	0	1468.0	1,171	491	530	132	350	86	0	10	5,917	24	9.93	2.15	4.63	0.81	27.4	5.9	1.04	.279	3.25	68	2.91	67	7.18	241.6
23	Tim Wakefield T. Wakefield	110	95	.537	346	250	4.33	1,209	7	0	7	1747.0	1,664	840	928	224	616	107	30	18	7,477	71	6.23	3.17	1.96	1.15	16.2	8.2	1.31	.271	4.78	93	4.60	106	8.57	-55.8
24	Roger Clemens R. Clemens	107	50	.682	229	228	3.34	1,356	3	1	0	1454.1	1,268	539	596	129	478	45	0	19	6,029	53	8.39	2.96	2.84	0.80	22.5	7.9	1.20	.283	3.69	75	3.42	76	7.85	169.1
25	Josh Beckett J. Beckett	106	68	.609	228	225	3.79	1,330	9	4	0	1401.0	1,280	590	641	151	426	48	1	14	5,835	44	8.54	2.74	3.12	0.97	22.8	7.3	1.22	.291	4.12	86	3.60	84	8.22	103.1