The Baltimore Orioles had their most runs in a game against the Red Sox on April 26, 2015 and on September 15, 1920, with 18 runs.

Interpreted as:

orioles most runs in a regular-season game vs red sox

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	18	4/26/2015	BAL	vs	BOS	W 18-7	44	20	4	1	1	17	4	0	5	0	0	49	29	6	0	1	0	0	.455	.490	.659	1.149
2	Browns	18	9/15/1920	SLA	vs	BSA	W 18-5	43	22	6	0	1	17	5	0	1	3	0	51	31	7	3				.512	.563	.721	1.283
3	Orioles	17	9/27/1960	BAL	@	BOS	W 17-3	44	18	3	1	4	16	8	0	7	0	0	53	35	8	0	1	0	1	.409	.491	.795	1.286
4	Orioles	16	8/25/2017	BAL	@	BOS	W 16-3	48	21	1	1	2	14	2	0	8	1	0	52	30	4	0	2	0	0	.438	.442	.625	1.067
5	Orioles	16	6/11/1993	BAL	@	BOS	W 16-4	45	16	7	0	1	13	4	1	7	0	0	52	26	8	0	2	1	0	.356	.404	.578	.982
6	Orioles	16	6/29/1985	BAL	@	BOS	W 16-4	44	19	4	0	2	16	5	0	4	1	0	51	29	6	0	2	0	1	.432	.471	.659	1.130
7	Orioles	16	9/9/1979	BAL	@	BOS	W 16-4	43	16	4	0	3	15	7	1	5	1	0	51	29	7	0	0	2	1	.372	.471	.674	1.145
8	Orioles	16	6/18/1966	BAL	@	BOS	W 16-6	44	18	3	1	5	16	8	0	9	0	0	53	38	9	1	0	0	0	.409	.500	.864	1.364
9	Browns	16	7/31/1941	SLA	@	BSA	W 16-11	38	14	5	0	1	16	12	1	3	0	0	54	22	6	3			1	.368	.529	.579	1.108
10	Orioles	15	8/19/2022	BAL	vs	BOS	W 15-10	40	18	6	0	5	15	3	1	6	0	0	45	39	11	0	1	0	0	.450	.489	.975	1.464
11	Orioles	15	9/20/1984	BAL	vs	BOS	W 15-1	44	20	8	0	2	15	6	0	11	1	0	50	34	10	0	0	1	0	.455	.520	.773	1.293
12	Browns	15	5/12/1929	SLA	vs	BSA	W 15-3	39	18	1	0	2	11	3	0	1	1	0	43	25	3	1				.462	.500	.641	1.141
13	Browns	15	6/10/1925	SLA	@	BSA	W 15-8	38	17	3	1	1	13	6	0	2	0	0	50	25	5	6				.447	.523	.658	1.181
14	Browns	15	6/12/1920	SLA	vs	BSA	W 15-4	44	22	6	2	0	14	3	0	2	2	0	48	32	8	1				.500	.532	.727	1.259
15	Browns	15	6/12/1906	SLA	vs	BSA	W 15-3	39	18	2	1	1	13		1		2			25	4	1				.462		.641
16	Orioles	14	9/26/2022	BAL	@	BOS	W 14-8	40	14	2	2	5	13	8	0	7	0	0	48	35	9	0	0	0	1	.350	.458	.875	1.333
17	Orioles	14	4/26/1997	BAL	vs	BOS	W 14-5	39	18	3	0	4	13	1	3	3	0	0	44	33	7	0	1	0	2	.462	.500	.846	1.346
18	Orioles	14	6/20/1986	BAL	@	BOS	W 14-3	44	20	3	0	0	14	9	1	6	0	0	56	23	3	1	1	0	1	.455	.545	.523	1.068
19	Browns	14	7/13/1927	SLA	vs	BSA	W 14-3	35	18	6	1	1	13	7	0	0	1	1	45	29	8	3				.514	.595	.829	1.424
20	Orioles	13	9/9/2023	BAL	@	BOS	W 13-12	41	14	4	0	5	12	3	0	10	0	0	44	33	9	0	0	1	0	.341	.386	.805	1.191
21	Orioles	13	9/24/2020	BAL	@	BOS	W 13-1	42	18	7	0	3	13	2	1	3	1	0	47	34	10	1	1	0	0	.429	.457	.810	1.266
22	Orioles	13	6/1/2016	BAL	vs	BOS	W 13-9	37	14	4	0	0	12	9	0	4	0	0	48	18	4	0	2	0	0	.378	.479	.486	.966
23	Orioles	13	5/31/2004	BAL	@	BOS	W 13-4	42	16	5	0	2	13	6	0	1	3	0	50	27	7	1	1	0	0	.381	.449	.643	1.092
24	Orioles	13	9/8/2003	BAL	vs	BOS	W 13-10	41	16	5	0	0	11	1	1	2	1	0	45	21	5	2	0	0	0	.390	.419	.512	.931
25	Orioles	13	4/12/2003	BAL	@	BOS	W 13-6	40	15	5	0	0	13	6	1	8	1	0	48	20	5	1	0	0	0	.375	.468	.500	.968