Between the 1960 and 1969 seasons, Bob Gibson struck out the most batters, with 2,071 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Bob Gibson B. Gibson	2,071	336	164	105	.610	302	2.74	164	41	4	2447.0	1,984	746	847	166	822	75	14	59	10,047	65	7.62	3.02	2.52	0.61	20.6	8.2	1.15	.263	3.12	74	2.81	78	7.30	202.9
2	Jim Bunning J. Bunning	2,019	378	150	118	.560	360	3.01	108	35	11	2590.1	2,338	867	984	230	621	111	15	67	10,670	31	7.01	2.16	3.25	0.80	18.9	5.8	1.14	.274	3.42	83	2.98	84	8.12	175.3
3	Don Drysdale D. Drysdale	1,910	371	158	126	.556	359	2.83	135	40	4	2629.2	2,341	827	961	207	598	112	10	102	10,718	64	6.54	2.05	3.19	0.71	17.8	5.6	1.12	.270	3.29	84	2.92	89	8.01	100
4	Sandy Koufax S. Koufax	1,910	260	137	60	.695	237	2.36	122	37	6	1807.2	1,304	474	542	136	512	14	14	36	7,216	57	9.51	2.55	3.73	0.68	26.5	7.1	1.00	.252	2.70	67	2.28	67	6.49	226.4
5	Juan Marichal J. Marichal	1,840	328	191	88	.685	320	2.57	197	45	2	2549.2	2,161	728	861	223	503	30	8	57	10,212	37	6.49	1.78	3.66	0.79	18.0	4.9	1.04	.254	3.04	74	2.84	84	7.63	148.5
6	Sam McDowell S. McDowell	1,663	262	89	80	.527	225	2.95	70	19	10	1590.0	1,207	522	608	91	788	43	19	38	6,689	84	9.41	4.46	2.11	0.52	24.9	11.8	1.25	.272	3.44	85	2.73	77	6.83	146.5
7	Jim Maloney J. Maloney	1,585	282	134	80	.626	255	3.08	74	30	3	1802.0	1,457	617	689	132	771	33	10	37	7,506	120	7.92	3.85	2.06	0.66	21.1	10.3	1.24	.266	3.44	84	3.05	86	7.28	98.1
8	Jim Kaat J. Kaat	1,435	353	142	119	.544	316	3.27	102	16	5	2223.2	2,156	809	983	204	561	81	16	41	9,322	82	5.81	2.27	2.56	0.83	15.4	6.0	1.22	.277	3.98	90	3.30	87	8.73	114.7
9	Bob Veale B. Veale	1,428	265	100	76	.568	223	2.83	73	19	4	1611.1	1,372	506	587	67	714	26	16	44	6,782	77	7.98	3.99	2.00	0.37	21.1	10.5	1.29	.287	3.28	82	2.67	81	7.66	114
10	Camilo Pascual C. Pascual	1,391	288	127	92	.580	273	3.34	93	26	2	1864.2	1,660	692	800	174	628	32	8	26	7,789	60	6.71	3.03	2.21	0.84	17.9	8.1	1.23	.267	3.86	92	3.32	89	8.01	92.4
11	Dean Chance D. Chance	1,361	327	115	100	.535	261	2.77	82	32	18	1900.2	1,598	586	706	99	628	55	40	59	7,813	58	6.44	2.97	2.17	0.47	17.4	8.0	1.17	.264	3.34	82	2.85	81	7.57	138.1
12	Mickey Lolich M. Lolich	1,336	267	102	74	.580	219	3.46	62	21	9	1528.1	1,318	587	640	145	518	60	25	27	6,375	53	7.87	3.05	2.58	0.85	21.0	8.1	1.20	.272	3.77	100	3.13	87	7.76	80.7
13	Earl Wilson E. Wilson	1,332	296	115	96	.545	281	3.59	65	12	0	1867.0	1,673	744	828	214	714	26	9	32	7,861	78	6.42	3.44	1.87	1.03	16.9	9.1	1.28	.262	3.99	99	3.78	101	8.06	-1.3
14	Chris Short C. Short	1,329	370	115	96	.545	239	3.19	76	20	13	1843.2	1,693	653	739	137	615	49	57	60	7,685	59	6.49	3.00	2.16	0.67	17.3	8.0	1.25	.280	3.61	91	3.13	93	8.26	47.3
15	Gaylord Perry G. Perry	1,234	289	95	84	.531	205	2.95	88	14	9	1685.2	1,514	552	638	118	430	37	30	77	6,932	62	6.59	2.30	2.87	0.63	17.8	6.2	1.15	.273	3.41	86	2.79	85	8.08	92.8
16	Larry Jackson L. Jackson	1,206	340	141	132	.516	321	3.29	116	30	0	2335.2	2,264	853	988	174	535	40	8	65	9,664	32	4.65	2.06	2.25	0.67	12.5	5.5	1.20	.271	3.81	89	3.21	90	8.72	94.7
17	Milt Pappas M. Pappas	1,201	326	131	102	.562	302	3.36	79	28	1	2033.2	1,893	759	840	199	558	47	17	58	8,395	60	5.32	2.47	2.15	0.88	14.3	6.6	1.21	.265	3.72	93	3.52	98	8.38	16.4
18	Ray Sadecki R. Sadecki	1,174	321	99	103	.490	261	3.91	72	17	4	1777.2	1,755	773	884	185	662	25	21	44	7,613	75	5.94	3.35	1.77	0.94	15.4	8.7	1.36	.282	4.48	106	3.71	103	8.89	-23.1
19	Denny Lemaster D. Lemaster	1,161	263	81	91	.471	228	3.43	63	14	3	1546.0	1,447	590	650	156	507	20	12	57	6,504	69	6.76	2.95	2.29	0.91	17.9	7.8	1.26	.277	3.78	101	3.35	102	8.42	-15.2
20	Steve Barber S. Barber	1,144	315	111	96	.536	263	3.27	59	21	5	1727.0	1,541	627	734	106	834	34	19	39	7,398	72	5.96	4.35	1.37	0.55	15.5	11.3	1.38	.272	3.83	94	3.51	98	8.03	12.5
21	Gary Bell G. Bell	1,132	442	93	96	.492	182	3.68	49	8	44	1599.0	1,445	653	755	161	664	44	147	60	6,806	58	6.37	3.74	1.70	0.91	16.6	9.8	1.32	.267	4.25	102	3.75	101	8.13	-10.8
22	Juan Pizarro J. Pizarro	1,119	351	100	78	.562	187	3.29	56	11	25	1477.0	1,302	540	622	137	616	22	91	49	6,273	46	6.82	3.75	1.82	0.83	17.8	9.8	1.30	.266	3.79	93	3.53	99	7.93	12.7
23	Dick Ellsworth D. Ellsworth	1,108	352	112	132	.459	308	3.69	87	9	2	2079.1	2,188	853	993	189	568	41	16	68	8,823	68	4.80	2.46	1.95	0.82	12.6	6.4	1.33	.289	4.30	99	3.53	97	9.47	27.3
24	Denny McLain D. McLain	1,098	213	114	57	.667	205	3.04	93	26	1	1501.2	1,221	507	554	176	422	19	2	16	6,041	22	6.58	2.53	2.60	1.05	18.2	7.0	1.09	.242	3.32	89	3.44	97	7.32	18.6
25	Gary Peters G. Peters	1,097	256	91	78	.538	216	2.92	60	18	3	1559.0	1,339	506	574	102	513	46	16	40	6,435	64	6.33	2.96	2.14	0.59	17.0	8.0	1.19	.264	3.31	87	3.04	88	7.73	71.9