The Boston Red Sox had their highest run differential in a season in 1912, with a differential of 255 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	255	1912	154	.691	105	47	5,071	799	1,404	269	84	29	654	565	45	586	185	182	5,872	1,928	382	191				.277	.355	.380	.735
2	Red Sox	229	2018	162	.667	108	54	5,623	876	1,509	355	31	208	829	569	55	1,253	125	31	6,302	2,550	594	7	48	38	130	.268	.339	.453	.792
3	Red Sox	229	1949	155	.623	96	58	5,320	896	1,500	272	36	131	835	835	17	510	43	25	6,250	2,237	439	78			169	.282	.381	.420	.802
4	Red Sox	223	1950	154	.610	94	60	5,516	1,027	1,665	287	61	161	974	719	25	580	32	17	6,322	2,557	509	62			153	.302	.385	.464	.848
5	Red Sox	210	2007	162	.593	96	66	5,589	867	1,561	352	35	166	829	689	64	1,042	96	24	6,426	2,481	553	30	54	54	146	.279	.362	.444	.806
6	Americans	203	1903	141	.659	91	47	4,919	708	1,336	222	113	48	609	262	36	559	141		5,365	1,928	383	148				.272	.313	.392	.705
7	Red Sox	198	1946	156	.675	104	50	5,318	792	1,441	268	50	109	737	687	15	661	45	36	6,126	2,136	427	106			133	.271	.356	.402	.758
8	Red Sox	197	2013	162	.599	97	65	5,651	853	1,566	363	29	178	819	581	72	1,308	123	19	6,378	2,521	570	24	50	51	137	.277	.349	.446	.795
9	Red Sox	194	2002	162	.574	93	69	5,640	859	1,560	348	33	177	810	545	72	944	80	28	6,332	2,505	558	22	53	39	139	.277	.345	.444	.789
10	Red Sox	187	1948	155	.619	96	59	5,363	907	1,471	277	40	121	854	821	32	549	38	17	6,282	2,191	438	66			144	.274	.374	.409	.782
11	Red Sox	184	2016	162	.574	93	69	5,670	878	1,598	343	25	208	836	558	43	1,160	83	24	6,319	2,615	576	8	40	34	137	.282	.348	.461	.810
12	Red Sox	181	2004	162	.605	98	64	5,720	949	1,613	373	25	222	912	659	69	1,189	68	30	6,515	2,702	620	12	55	39	123	.282	.360	.472	.832
13	Red Sox	169	1915	155	.669	101	50	5,024	668	1,308	202	76	14	574	527	49	476	118	117	5,865	1,704	292	265				.260	.336	.339	.676
14	Red Sox	167	1942	152	.612	93	59	5,248	761	1,451	244	55	103	702	591	22	508	68	61	5,984	2,114	402	123			94	.276	.352	.403	.755
15	Red Sox	152	2003	162	.586	95	67	5,769	961	1,667	371	40	238	932	620	53	943	88	35	6,530	2,832	649	24	64	61	126	.289	.360	.491	.851
16	Red Sox	151	2008	162	.586	95	67	5,596	845	1,565	353	33	173	807	646	70	1,068	120	35	6,402	2,503	559	28	62	49	147	.280	.358	.447	.805
17	Red Sox	151	1938	150	.591	88	61	5,229	902	1,566	298	56	98	860	649	13	462	55	51	6,003	2,270	452	112				.299	.378	.434	.812
18	Americans	151	1901	138	.581	79	57	4,866	759	1,353	183	104	37	632	331	47	281	157		5,349	1,855	324	105				.278	.330	.381	.711
19	Red Sox	147	1998	162	.568	92	70	5,601	876	1,568	338	35	205	827	541	70	1,049	72	39	6,299	2,591	578	35	52	32	144	.280	.348	.463	.810
20	Red Sox	147	1977	161	.602	97	64	5,510	859	1,551	258	56	213	828	528	42	905	66	47	6,184	2,560	527	45	59	38	132	.281	.345	.465	.810
21	Americans	142	1904	157	.617	95	59	5,231	608	1,294	194	105	26	522	347	51	573	101		5,784	1,776	325	155				.247	.301	.340	.640
22	Red Sox	139	1978	163	.607	99	64	5,587	796	1,493	270	46	172	738	582	24	835	74	51	6,316	2,371	488	65	58	43	135	.267	.336	.424	.760
23	Red Sox	138	2011	162	.556	90	72	5,710	875	1,600	352	35	203	842	578	50	1,108	102	42	6,410	2,631	590	22	50	52	136	.280	.349	.461	.810
24	Red Sox	136	2009	162	.586	95	67	5,543	872	1,495	335	25	212	822	659	70	1,120	126	39	6,342	2,516	572	19	51	39	137	.270	.352	.454	.806
25	Red Sox	130	1979	160	.569	91	69	5,538	841	1,567	310	34	194	805	512	33	708	60	43	6,184	2,527	538	42	59	38	158	.283	.344	.456	.800