Luis Castillo has a 44-53 record with an ERA of 3.62 and 860 strikeouts in 137 appearances for the Reds in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2017 |  CIN | 15 | 3 | 7 | .300 | 15 | 3.12 | 98 | 0 | 0 | 0 | 89.1 | 64 | 31 | 32 | 11 | 32 | 3 | 0 | 1 | 359 | 2 | 9.87 | 3.22 | 3.06 | 1.11 | 27.3 | 8.9 | 1.07 | .247 | 3.22 | 71 | 3.73 | 85 | 6.45 | 6.6 |
| 2 | | L. Castillo | 2018 | CIN | 31 | 10 | 12 | .455 | 31 | 4.30 | 165 | 0 | 0 | 0 | 169.2 | 158 | 81 | 89 | 28 | 49 | 5 | 0 | 1 | 708 | 4 | 8.75 | 2.60 | 3.37 | 1.49 | 23.3 | 6.9 | 1.22 | .282 | 4.72 | 105 | 4.31 | 103 | 8.38 | -2.2 |
| 3 | | L. Castillo | 2019 | CIN | 32 | 15 | 8 | .652 | 32 | 3.40 | 226 | 0 | 0 | 0 | 190.2 | 139 | 72 | 76 | 22 | 79 | 7 | 0 | 0 | 781 | 5 | 10.67 | 3.73 | 2.86 | 1.04 | 28.9 | 10.1 | 1.14 | .262 | 3.59 | 74 | 3.69 | 80 | 6.56 | 19 |
| 4 | | L. Castillo | 2020 | CIN | 12 | 4 | 6 | .400 | 12 | 3.21 | 89 | 1 | 0 | 0 | 70.0 | 62 | 25 | 31 | 5 | 24 | 1 | 0 | 0 | 292 | 1 | 11.44 | 3.09 | 3.71 | 0.64 | 30.5 | 8.2 | 1.23 | .329 | 3.99 | 68 | 2.64 | 57 | 7.97 | 15.2 |
| 5 | | L. Castillo | 2021 | CIN | 33 | 8 | 16 | .333 | 33 | 3.98 | 192 | 0 | 0 | 0 | 187.2 | 181 | 83 | 94 | 19 | 75 | 7 | 0 | 4 | 803 | 1 | 9.21 | 3.60 | 2.56 | 0.91 | 23.9 | 9.3 | 1.36 | .318 | 4.51 | 90 | 3.74 | 84 | 8.68 | 14.5 |
| 6 | | L. Castillo | 2022 | CIN | 14 | 4 | 4 | .500 | 14 | 2.86 | 90 | 0 | 0 | 0 | 85.0 | 63 | 27 | 30 | 7 | 28 | 4 | 0 | 0 | 349 | 0 | 9.53 | 2.96 | 3.21 | 0.74 | 25.8 | 8.0 | 1.07 | .255 | 3.18 | 67 | 3.19 | 76 | 6.67 | 9.1 |
| Total | 137 | 44 | 53 | .454 | 137 | 3.62 | 860 | 1 | 0 | 0 | 792.1 | 667 | 319 | 352 | 92 | 287 | 27 | 0 | 6 | 3,292 | 13 | 9.77 | 3.26 | 3.00 | 1.05 | 26.1 | 8.7 | 1.20 | .284 | 4.00 | 83 | 3.69 | 84 | 7.58 | 62.2 |
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