Sean Manaea struck out his most batters in a game against the Mariners on July 22, 2021, with 13 strikeouts.

Interpreted as:

Sean Manaea most strike outs in a regular-season game

	NAME	SO	DATE	TM		OPP	DEC	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Sean Manaea S. Manaea	13	7/22/2021	OAK	@	SEA	W	1	1.29	0	0	0	7.0	3	1	1	1	3	1	0	0	28	0
2	Sean Manaea S. Manaea	12	5/14/2022	SDP	@	ATL		1	3.86	0	0	0	7.0	6	3	3	1	2	0	0	0	27	0
3	Sean Manaea S. Manaea	11	8/27/2024	NYM	@	ARI	W	1	4.05	0	0	0	6.2	4	3	3	2	0	0	0	0	25	0
4	Sean Manaea S. Manaea	11	7/30/2024	NYM	vs	MIN	W	1	0.00	0	0	0	7.0	2	0	0	0	1	0	0	0	24	0
5	Sean Manaea S. Manaea	11	6/20/2021	OAK	@	NYY	L	1	3.38	0	0	0	5.1	3	2	2	0	2	0	0	0	21	0
6	Sean Manaea S. Manaea	10	8/5/2024	NYM	@	STL	W	1	0.00	0	0	0	7.0	6	0	0	0	0	0	0	0	28	1
7	Sean Manaea S. Manaea	10	6/1/2024	NYM	vs	ARI	L	1	7.94	0	0	0	5.2	6	5	6	1	2	0	0	0	25	0
8	Sean Manaea S. Manaea	10	5/7/2021	OAK	vs	TBR		1	1.23	0	0	0	7.1	2	1	1	0	1	0	0	0	25	0
9	Sean Manaea S. Manaea	10	9/8/2019	OAK	vs	DET	W	1	1.29	0	0	0	7.0	2	1	1	1	2	0	0	0	25	0
10	Sean Manaea S. Manaea	10	4/21/2018	OAK	vs	BOS	W	1	0.00	1	1	0	9.0	0	0	0	0	2	0	0	0	30	1
11	Sean Manaea S. Manaea	10	4/9/2017	OAK	@	TEX	L	1	8.44	0	0	0	5.1	3	5	6	1	2	2	0	0	24	1
12	Sean Manaea S. Manaea	9	9/6/2024	NYM	vs	CIN		1	5.40	0	0	0	6.2	3	4	4	2	2	1	0	0	24	0
13	Sean Manaea S. Manaea	9	8/21/2024	NYM	vs	BAL		1	3.86	0	0	0	7.0	3	3	3	1	0	1	0	0	25	0
14	Sean Manaea S. Manaea	9	7/12/2024	NYM	vs	COL	W	1	3.86	0	0	0	7.0	5	3	3	2	1	0	0	0	27	0
15	Sean Manaea S. Manaea	9	9/9/2021	OAK	vs	CWS	W	1	1.29	0	0	0	7.0	5	1	1	0	1	0	0	0	26	0
16	Sean Manaea S. Manaea	9	9/3/2021	OAK	@	TOR		1	2.57	0	0	0	7.0	5	2	2	1	0	0	0	0	26	0
17	Sean Manaea S. Manaea	9	7/28/2021	OAK	@	SDP	W	1	0.00	0	0	0	6.0	1	0	0	0	1	0	0	0	20	0
18	Sean Manaea S. Manaea	9	5/31/2017	OAK	@	CLE	W	1	1.29	0	0	0	7.0	3	1	1	1	1	0	0	0	24	1
19	Sean Manaea S. Manaea	9	7/27/2016	OAK	@	TEX		1	4.05	0	0	0	6.2	11	3	3	1	0	0	0	0	29	0
20	Sean Manaea S. Manaea	8	8/26/2025	NYM	vs	PHI		1	3.86	0	0	0	4.2	6	2	2	0	0	0	0	0	19	0
21	Sean Manaea S. Manaea	8	8/21/2025	NYM	@	WSH	L	1	7.71	0	0	0	4.2	3	4	4	0	1	2	0	0	22	1
22	Sean Manaea S. Manaea	8	9/11/2024	NYM	@	TOR		1	1.35	0	0	0	6.2	3	1	1	0	4	0	0	0	27	0
23	Sean Manaea S. Manaea	8	4/1/2024	NYM	vs	DET		1	0.00	0	0	0	6.0	1	0	0	0	2	0	0	0	20	0
24	Sean Manaea S. Manaea	8	9/27/2023	SFG	vs	SDP		1	3.00	0	0	0	6.0	7	2	2	1	0	0	0	0	24	0
25	Sean Manaea S. Manaea	8	5/22/2023	SFG	@	MIN	W	0	0.00	0	0	0	3.2	3	0	0	0	3	0	0	0	17	0

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Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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