Ty Cobb has put up the most career runs at home, with 1,110 runs.

Interpreted as:

stadium with the most runs by a player at home

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Ty Cobb T. Cobb	1,110	1,509	5,528	2,031	374	160	35		646	43		456		6,359	2,830	569	147				.367		.512
2	Barry Bonds B. Bonds	1,105	1,492	4,757	1,430	292	40	379	980	1,256	60	754	259	62	6,124	2,939	711	4	47	340	79	.301	.449	.618	1.067
3	Pete Rose P. Rose	1,092	1,775	6,850	2,123	396	74	85	686	789	69	523	103	63	7,784	2,922	555	25	51	83	120	.310	.384	.427	.811
4	Rickey Henderson R. Henderson	1,088	1,543	5,319	1,455	227	32	135	526	1,079	42	802	663	181	6,489	2,151	394	15	34	32	81	.274	.398	.404	.802
5	Hank Aaron H. Aaron	1,081	1,647	5,968	1,811	283	37	385	1,117	746	17	652	117	32	6,804	3,323	705	15	58	159	133	.303	.379	.557	.936
6	Babe Ruth B. Ruth	1,078	1,253	4,036	1,398	239	70	347	1,062	1,044	18	615	72		5,150	2,818	656	52				.346	.483	.698	1.181
7	Alex Rodriguez A. Rodriguez	1,022	1,396	5,223	1,574	283	14	354	1,076	652	91	1,131	180	30	6,032	2,947	651	7	59	49	141	.301	.385	.564	.949
8	Willie Mays W. Mays	1,017	1,490	5,238	1,583	258	61	335	929	721	23	659	147	47	6,027	2,968	654	9	36	92	121	.302	.387	.567	.953
9	Derek Jeter D. Jeter	1,013	1,391	5,517	1,727	273	30	138	666	569	82	891	194	44	6,241	2,474	441	51	22	21	136	.313	.384	.448	.833
10	Stan Musial S. Musial	999	1,524	5,402	1,815	394	90	252	1,056	857	25	338	39	11	6,332	3,145	736	17	31	69	122	.336	.427	.582	1.009
11	Carl Yastrzemski C. Yastrzemski	994	1,676	5,948	1,822	382	38	237	1,063	959	25	642	81	49	6,996	2,991	657	8	56	109	157	.306	.402	.503	.904
12	Tristram Speaker T. Speaker	980	1,408	5,008	1,828	469	114	59		728	51		219		5,941	2,702	642	154				.365	.450	.540	.990
13	Ted Williams T. Williams	974	1,165	3,887	1,403	319	35	248	965	1,031	22	322	17	2	4,954	2,536	602	3	11	50	98	.361	.496	.652	1.148
14	Frank Robinson F. Robinson	958	1,383	4,779	1,462	255	28	321	970	708	101	709	91	34	5,649	2,736	604	7	54	122	131	.306	.403	.573	.975
15	Mel Ott M. Ott	954	1,367	4,576	1,360	182	21	323	947	955	31	429	49		5,600	2,553	526	38			20	.297	.422	.558	.980
16	Charlie Gehringer C. Gehringer	949	1,176	4,386	1,417	297	62	92	764	618	24	177	97		5,101	2,114	451	73			18	.323	.410	.482	.891
17	Craig Biggio C. Biggio	948	1,447	5,481	1,579	365	34	143	599	592	148	882	233	65	6,313	2,441	542	52	40	32	68	.288	.370	.445	.816
18	Albert Pujols A. Pujols	932	1,542	5,583	1,668	358	4	333	1,104	695	63	648	61	23	6,397	3,033	695	1	55	145	201	.299	.379	.543	.923
19	Jimmie Foxx J. Foxx	930	1,145	3,885	1,341	220	58	299	1,029	760	9	615	44		4,678	2,574	577	24			34	.345	.453	.663	1.116
20	Paul Molitor P. Molitor	903	1,340	5,292	1,676	301	61	116	672	539	21	579	247	63	5,943	2,447	478	31	60	47	106	.317	.378	.462	.841
21	Eddie Collins E. Collins	901	1,417	4,890	1,630	217	102	16		731	38		355		5,913	2,099	335	254				.333	.424	.429	.853
22	Lou Gehrig L. Gehrig	882	1,080	3,861	1,269	206	83	251	951	714	22	375	43		4,660	2,394	540	63			2	.329	.436	.620	1.056
23	Todd Helton T. Helton	874	1,141	4,038	1,394	321	28	227	859	710	29	514	24	15	4,839	2,452	576	2	60	99	97	.345	.441	.607	1.048
24	Rafael Palmeiro R. Palmeiro	866	1,424	5,135	1,466	265	22	311	935	736	40	702	47	19	5,981	2,708	598	10	60	98	123	.285	.375	.527	.903
25	Paul Waner P. Waner	864	1,284	4,706	1,628	316	129	58	700	560	17	153	46		5,379	2,376	503	96			16	.346	.417	.505	.922

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StatMuse has game-level data for runs going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Thu 3/26	DET	@	SDP	4:10 PM
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Braves	76	86	.469	20.0
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Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Ty Cobb has put up the most career runs at home, with 1,110 runs.

Interpreted as:

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