The Brooklyn Dodgers had the highest run differential by a team in 1952, with a differential of 172 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	172	1952	155	.627	96	57	5,266	775	1,380	199	32	153	725	663	35	699	90	49	6,068	2,102	384	104	151	.262	.348	.399	.748
2	Yankees	170	1952	154	.617	95	59	5,294	727	1,411	221	56	129	670	565	36	652	52	42	5,989	2,131	406	94	93	.267	.341	.403	.744
3	Indians	157	1952	155	.604	93	61	5,330	763	1,399	211	49	148	721	626	20	749	46	39	6,060	2,152	408	84	124	.262	.342	.404	.746
4	Phillies	105	1952	154	.565	87	67	5,205	657	1,353	237	45	93	606	540	22	534	60	41	5,874	1,959	375	107	115	.260	.332	.376	.708
5	Giants	83	1952	154	.597	92	62	5,229	722	1,337	186	56	151	663	536	38	672	30	31	5,891	2,088	393	88	96	.256	.329	.399	.729
6	Cardinals	47	1952	154	.571	88	66	5,200	677	1,386	247	54	97	643	537	43	479	33	32	5,845	2,032	398	65	122	.267	.340	.391	.731
7	White Sox	42	1952	156	.526	81	73	5,316	610	1,337	199	38	80	560	541	58	519	61	38	6,036	1,852	317	121	121	.252	.327	.348	.676
8	Red Sox	10	1952	154	.494	76	78	5,246	668	1,338	233	34	113	628	542	31	737	59	47	5,885	1,978	380	66	133	.255	.328	.377	.705
9	Cubs	-3	1952	155	.500	77	77	5,330	628	1,408	223	45	107	595	422	21	712	50	40	5,836	2,042	375	63	133	.264	.321	.383	.704
10	Senators	-10	1952	157	.506	78	76	5,357	598	1,282	225	44	50	555	580	30	605	48	37	6,046	1,745	319	79	137	.239	.317	.326	.643
11	Reds	-44	1952	154	.448	69	85	5,234	615	1,303	212	45	104	562	480	18	709	32	42	5,785	1,917	361	53	110	.249	.314	.366	.680
12	Athletics	-59	1952	155	.513	79	75	5,163	664	1,305	212	35	89	632	683	27	558	52	43	5,975	1,854	336	102	152	.253	.343	.359	.702
13	Braves	-82	1952	155	.418	64	89	5,221	569	1,214	187	31	110	530	483	32	711	58	34	5,828	1,793	328	92	117	.233	.301	.343	.645
14	Browns	-129	1952	155	.416	64	90	5,353	604	1,340	225	46	82	574	540	22	717	30	34	6,001	1,903	353	86	112	.250	.322	.356	.677
15	Tigers	-181	1952	156	.325	50	104	5,258	557	1,278	190	37	103	529	553	23	603	27	38	5,914	1,851	330	80	146	.243	.318	.352	.670
16	Pirates	-278	1952	155	.273	42	112	5,193	515	1,201	181	30	92	478	486	26	724	43	41	5,775	1,718	303	70	104	.231	.300	.331	.631