The Detroit Tigers had the highest run differential by a team in 1968, with a differential of 179 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Tigers	179	1968	164	.636	103	59	5,490	671	1,292	190	39	185	639	521	61	964	26	32	6,179	2,115	414	73	34	53	124	.235	.307	.385	.692
2	Cardinals	111	1968	162	.599	97	65	5,561	583	1,383	227	48	73	539	378	32	897	110	45	6,080	1,925	348	67	42	56	91	.249	.298	.346	.644
3	Orioles	82	1968	162	.562	91	71	5,275	579	1,187	215	28	133	534	570	48	1,019	78	32	6,022	1,857	376	80	49	63	102	.225	.304	.352	.656
4	Giants	70	1968	163	.543	88	74	5,441	599	1,301	162	33	108	566	508	47	904	50	37	6,132	1,853	303	92	44	55	117	.239	.307	.341	.648
5	Pirates	51	1968	163	.494	80	82	5,569	583	1,404	180	44	80	538	422	33	953	130	59	6,163	1,912	304	96	43	93	133	.252	.306	.343	.650
6	Athletics	25	1968	163	.506	82	80	5,406	569	1,300	192	40	94	522	472	35	1,022	147	61	6,026	1,854	326	78	35	53	87	.240	.304	.343	.647
7	Reds	17	1968	163	.512	83	79	5,767	690	1,573	281	36	106	638	379	37	938	59	55	6,286	2,244	423	64	39	95	142	.273	.320	.389	.709
8	Twins	16	1968	162	.488	79	83	5,373	562	1,274	207	41	105	522	445	49	966	98	54	5,974	1,878	353	69	38	61	106	.237	.299	.350	.649
9	Indians	12	1968	162	.534	86	75	5,416	516	1,266	210	36	75	476	427	39	858	115	61	5,988	1,773	321	69	37	51	96	.234	.293	.327	.620
10	Yankees	5	1968	164	.512	83	79	5,310	536	1,137	154	34	109	501	566	30	958	90	50	5,992	1,686	297	56	30	52	100	.214	.292	.318	.609
11	Red Sox	3	1968	162	.531	86	76	5,303	614	1,253	207	17	125	558	582	33	974	76	62	6,036	1,869	349	77	41	58	121	.236	.313	.352	.666
12	Cubs	1	1968	163	.519	84	78	5,458	612	1,319	203	43	130	576	415	36	854	41	30	6,020	1,998	376	74	37	58	103	.242	.298	.366	.664
13	Mets	-26	1968	163	.451	73	89	5,503	473	1,252	178	30	81	434	379	43	1,203	72	45	6,027	1,733	289	75	27	50	104	.228	.281	.315	.596
14	Braves	-35	1968	163	.500	81	81	5,552	514	1,399	179	31	80	480	414	36	782	83	44	6,118	1,880	290	86	30	85	145	.252	.307	.339	.645
15	Dodgers	-39	1968	162	.469	76	86	5,354	470	1,234	202	36	67	434	439	18	980	57	43	5,935	1,709	305	79	45	61	89	.230	.289	.319	.608
16	White Sox	-64	1968	162	.414	67	95	5,405	463	1,233	169	33	71	431	397	40	840	90	50	5,965	1,681	273	90	33	47	108	.228	.284	.311	.595
17	Phillies	-72	1968	162	.469	76	86	5,372	543	1,253	178	30	100	505	462	22	1,003	58	51	5,966	1,791	308	64	46	60	106	.233	.294	.333	.628
18	Astros	-78	1968	162	.444	72	90	5,336	510	1,233	205	28	66	473	479	48	988	44	51	5,994	1,692	299	97	34	81	115	.231	.298	.317	.616
19	Angels	-117	1968	162	.414	67	95	5,331	498	1,209	170	33	83	453	447	52	1,080	62	50	5,942	1,694	286	75	37	41	103	.227	.291	.318	.609
20	Senators	-141	1968	161	.404	65	96	5,400	524	1,208	160	37	124	489	454	39	960	29	19	5,971	1,814	321	46	32	50	125	.224	.287	.336	.623