The Baltimore Orioles had the highest run differential by a team in 1973, with a differential of 193 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	193	1973	162	.599	97	65	5,537	754	1,474	229	48	119	692	648	43	752	146	64	6,335	2,156	396	58	49	49	126	.266	.345	.389	.734
2	Athletics	143	1973	162	.580	94	68	5,507	758	1,431	216	28	147	714	595	35	919	128	57	6,257	2,144	391	67	53	53	118	.260	.333	.389	.722
3	Reds	120	1973	162	.611	99	63	5,505	741	1,398	232	34	137	686	639	31	947	148	55	6,304	2,109	403	78	51	74	118	.254	.332	.383	.715
4	Dodgers	110	1973	162	.590	95	66	5,604	675	1,473	219	29	110	623	497	28	795	109	50	6,267	2,080	358	81	57	92	123	.263	.323	.371	.694
5	Red Sox	91	1973	162	.549	89	73	5,513	738	1,472	235	30	147	692	581	31	799	114	45	6,223	2,208	412	54	44	49	143	.267	.338	.401	.738
6	Twins	46	1973	162	.500	81	81	5,625	738	1,521	240	44	120	688	598	34	954	87	46	6,331	2,209	404	34	40	49	150	.270	.342	.393	.735
7	Cardinals	40	1973	162	.500	81	81	5,478	643	1,418	240	35	75	592	531	29	796	100	46	6,177	1,953	350	89	50	82	149	.259	.325	.357	.681
8	Giants	37	1973	162	.543	88	74	5,537	739	1,452	212	52	161	684	590	35	913	112	52	6,274	2,251	425	75	37	82	113	.262	.335	.407	.742
9	Yankees	31	1973	162	.494	80	82	5,492	641	1,435	212	17	131	616	489	22	680	47	43	6,064	2,074	360	27	34	34	142	.261	.322	.378	.700
10	Braves	25	1973	162	.472	76	85	5,631	799	1,497	219	34	206	758	608	34	870	84	40	6,384	2,402	459	65	46	66	112	.266	.339	.427	.765
11	Mets	20	1973	161	.509	82	79	5,457	608	1,345	198	24	85	553	540	23	805	27	22	6,164	1,846	307	108	36	54	147	.246	.315	.338	.653
12	Pirates	11	1973	162	.494	80	82	5,608	704	1,465	257	44	154	664	432	27	842	23	30	6,167	2,272	455	60	40	73	130	.261	.315	.405	.720
13	Astros	9	1973	162	.506	82	80	5,532	681	1,391	216	35	134	634	469	33	962	92	48	6,153	2,079	385	83	36	72	135	.251	.312	.376	.688
14	Royals	3	1973	162	.543	88	74	5,508	755	1,440	239	40	114	703	644	26	696	105	69	6,274	2,101	393	49	47	44	134	.261	.339	.381	.720
15	Brewers	-23	1973	162	.457	74	88	5,526	708	1,399	229	40	145	669	563	42	977	110	66	6,227	2,143	414	61	35	44	114	.253	.325	.388	.713
16	Angels	-28	1973	162	.488	79	83	5,505	629	1,395	183	29	93	595	509	34	816	59	47	6,153	1,915	305	60	45	42	131	.253	.318	.348	.666
17	Tigers	-32	1973	162	.525	85	77	5,508	642	1,400	213	32	157	592	509	39	722	28	30	6,135	2,148	402	48	31	47	147	.254	.320	.390	.710
18	Expos	-34	1973	162	.488	79	83	5,369	668	1,345	190	23	125	613	695	44	777	77	68	6,251	1,956	338	115	28	76	144	.251	.340	.364	.704
19	Cubs	-41	1973	161	.478	77	84	5,363	614	1,322	201	21	117	570	575	20	855	65	58	6,070	1,916	339	75	37	77	144	.247	.320	.357	.677
20	White Sox	-53	1973	162	.475	77	85	5,475	652	1,400	228	38	111	598	537	32	952	83	73	6,135	2,037	377	49	42	31	146	.256	.324	.372	.696
21	Phillies	-75	1973	162	.438	71	91	5,546	642	1,381	218	29	134	592	476	33	979	51	47	6,156	2,059	381	56	45	68	91	.249	.310	.371	.681
22	Indians	-146	1973	162	.438	71	91	5,592	680	1,429	205	29	158	636	471	32	793	60	68	6,178	2,166	392	40	43	26	125	.256	.315	.387	.702
23	Padres	-222	1973	162	.370	60	102	5,457	548	1,330	198	26	112	516	401	21	966	88	36	5,985	1,916	336	73	33	46	115	.244	.296	.351	.647
24	Rangers	-225	1973	162	.352	57	105	5,488	619	1,397	195	29	110	574	503	27	791	91	53	6,113	1,980	334	45	50	27	132	.255	.318	.361	.678