The Chicago Cubs have the highest run differential by a team this season, with a differential of 102 runs.

Interpreted as:

team with the biggest run differential this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	102	2025	60	.633	38	22	2,084	349	545	115	15	81	341	227	16	473	79	14	2,355	933	211	6	22	8	29	.262	.335	.448	.783
2	Yankees	99	2025	59	.627	37	22	2,000	322	516	107	10	97	309	243	29	518	42	14	2,297	934	214	1	24	16	36	.258	.343	.467	.810
3	Tigers	91	2025	62	.645	40	22	2,098	310	526	95	10	73	296	206	26	557	21	6	2,350	860	178	4	16	5	37	.251	.323	.410	.733
4	Dodgers	79	2025	60	.600	36	24	2,057	346	551	102	9	98	333	229	20	493	40	12	2,330	965	209	3	21	12	47	.268	.344	.469	.813
5	Mets	68	2025	60	.633	38	22	1,985	264	488	102	13	68	255	216	38	463	46	8	2,264	820	183	3	22	13	53	.246	.328	.413	.741
6	Rays	45	2025	60	.517	31	29	2,003	261	493	93	3	62	249	182	16	502	84	17	2,219	778	158	1	17	1	40	.246	.312	.388	.700
7	Giants	41	2025	60	.550	33	27	1,980	248	459	86	9	57	237	210	20	511	36	13	2,232	734	152	10	12	5	41	.232	.310	.371	.681
8	Twins	36	2025	59	.542	32	27	1,980	243	477	95	7	56	233	165	39	481	32	12	2,199	754	158	1	14	4	37	.241	.310	.381	.691
9	Reds	31	2025	62	.484	30	32	2,080	279	509	105	7	64	267	213	20	553	55	19	2,330	820	176	3	14	6	37	.245	.319	.394	.713
10	Phillies	27	2025	60	.617	37	23	2,054	289	528	92	9	66	274	221	22	473	56	11	2,317	836	167	5	15	6	36	.257	.333	.407	.740
11	Cardinals	27	2025	60	.550	33	27	2,038	280	527	112	4	54	265	197	27	465	35	12	2,286	809	170	6	18	9	45	.259	.329	.397	.726
12	Astros	18	2025	60	.550	33	27	1,991	242	502	81	6	61	231	173	28	457	30	13	2,215	778	148	8	15	6	49	.252	.319	.391	.709
13	Padres	17	2025	58	.586	34	24	1,920	243	476	86	7	53	223	178	14	401	42	12	2,145	735	146	15	18	6	37	.248	.314	.383	.696
14	Brewers	17	2025	62	.532	33	29	2,075	279	492	88	5	55	256	214	25	505	81	19	2,342	755	148	14	14	8	28	.237	.314	.364	.678
15	Red Sox	11	2025	63	.460	29	34	2,194	292	553	119	8	74	280	212	24	582	56	13	2,446	910	201	5	11	13	30	.252	.323	.415	.738
16	Braves	8	2025	59	.458	27	32	2,002	239	491	82	6	63	229	200	17	501	35	11	2,236	774	151	6	11	4	36	.245	.317	.387	.704
17	Mariners	4	2025	59	.542	32	27	2,005	264	474	71	3	80	255	219	31	528	54	18	2,275	791	154	9	11	4	35	.236	.320	.395	.714
18	Rangers	-1	2025	61	.475	29	32	1,963	205	435	71	6	60	200	156	20	496	55	14	2,158	698	137	3	16	3	30	.222	.284	.356	.639
19	Royals	-4	2025	61	.525	32	29	2,042	204	507	101	12	36	201	144	21	424	48	22	2,242	740	149	14	21	9	27	.248	.302	.362	.664
20	Diamondbacks	-5	2025	60	.483	29	31	2,038	304	520	117	12	84	297	216	29	446	51	12	2,314	913	213	8	23	7	41	.255	.332	.448	.780
21	Blue Jays	-10	2025	60	.517	31	29	2,014	251	509	102	2	60	241	211	21	420	35	9	2,278	795	164	13	19	11	45	.253	.327	.395	.722
22	Guardians	-17	2025	59	.542	32	27	1,923	237	450	82	6	61	224	190	23	470	44	14	2,167	727	149	8	23	9	34	.234	.307	.378	.685
23	Nationals	-42	2025	60	.467	28	32	2,001	268	488	103	10	60	255	175	31	467	56	20	2,231	791	173	10	14	2	36	.244	.312	.395	.708
24	Angels	-55	2025	60	.467	28	32	1,993	246	448	81	6	87	237	153	25	583	25	10	2,191	802	174	6	14	6	36	.225	.286	.402	.689
25	White Sox	-57	2025	61	.311	19	42	1,988	210	440	90	3	48	203	198	13	513	47	11	2,220	680	141	7	14	1	34	.221	.294	.342	.636