Between the 2011 and 2015 seasons, the St. Louis Cardinals had the most wins by a team, with 465 wins.

Interpreted as:

team with the most regular-season wins 2011 to 2015

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	465	345	.574	810	27,621	3,576	7,290	1,483	139	688	3,407	2,533	313	5,680	319	168	30,993	11,115	2,310	312	214	222	726	.264	.330	.402	.733
2	Yankees	448	362	.553	810	27,555	3,718	6,981	1,313	115	970	3,552	2,664	312	5,888	530	155	30,924	11,434	2,398	156	237	137	619	.253	.324	.415	.739
3	Dodgers	446	363	.551	809	27,310	3,315	7,033	1,352	132	692	3,162	2,537	275	5,893	505	196	30,644	10,725	2,176	320	202	216	624	.258	.325	.393	.717
4	Nationals	443	366	.548	809	27,462	3,400	6,918	1,347	114	838	3,203	2,469	246	6,488	457	147	30,691	11,007	2,299	315	199	185	572	.252	.317	.401	.718
5	Tigers	440	369	.544	809	28,009	3,755	7,704	1,482	171	814	3,606	2,461	224	5,722	332	155	31,099	11,970	2,467	165	240	220	733	.275	.336	.427	.763
6	Angels	436	374	.538	810	27,706	3,601	7,183	1,379	147	837	3,407	2,341	264	5,836	484	192	30,739	11,367	2,363	197	231	178	642	.259	.320	.410	.731
7	Rangers	435	376	.536	811	27,805	3,781	7,409	1,414	147	869	3,582	2,335	294	5,495	589	233	30,881	11,724	2,430	204	243	174	627	.266	.327	.422	.749
8	Pirates	431	379	.532	810	27,486	3,274	6,882	1,358	164	734	3,123	2,383	340	6,558	477	238	30,719	10,770	2,256	316	194	196	583	.250	.316	.392	.708
9	Rays	430	381	.530	811	27,373	3,360	6,782	1,360	146	796	3,207	2,694	317	6,121	512	216	30,773	10,822	2,302	157	232	141	630	.248	.320	.395	.715
10	Giants	428	382	.528	810	27,684	3,278	7,161	1,394	197	599	3,104	2,284	212	5,701	419	179	30,699	10,746	2,190	287	232	198	617	.259	.318	.388	.706
11	Braves	425	385	.525	810	27,282	3,175	6,717	1,245	107	726	3,015	2,556	204	6,409	406	173	30,517	10,354	2,078	306	169	188	609	.246	.314	.380	.693
12	Orioles	424	386	.523	810	27,846	3,583	7,073	1,351	79	1,045	3,447	2,167	251	6,176	306	128	30,594	11,717	2,475	144	186	136	650	.254	.312	.421	.732
13	Athletics	420	390	.519	810	27,645	3,548	6,807	1,378	165	787	3,360	2,693	229	5,882	474	152	30,903	10,876	2,330	115	221	133	566	.246	.316	.393	.709
14	Royals	413	397	.510	810	27,977	3,429	7,448	1,460	183	606	3,261	2,031	253	5,044	695	198	30,680	11,092	2,249	185	234	160	646	.266	.319	.396	.716
15	Reds	406	404	.501	810	27,554	3,337	6,849	1,345	116	808	3,172	2,512	280	6,268	507	202	30,905	10,850	2,269	359	200	231	527	.249	.316	.394	.709
16	Indians	406	403	.502	809	27,513	3,454	6,962	1,433	125	744	3,301	2,648	256	5,985	506	177	30,831	10,877	2,302	177	237	135	618	.253	.322	.395	.717
17	Red Sox	405	405	.500	810	28,156	3,844	7,475	1,630	133	830	3,663	2,600	281	6,098	456	144	31,416	11,861	2,593	130	249	194	643	.265	.331	.421	.752
18	Blue Jays	404	406	.499	810	27,641	3,785	7,043	1,395	121	978	3,592	2,580	236	5,860	532	178	30,853	11,614	2,494	164	232	128	618	.255	.321	.420	.741
19	Brewers	403	407	.498	810	27,420	3,442	6,989	1,385	175	839	3,285	2,189	331	6,002	580	192	30,488	11,241	2,399	363	185	177	606	.255	.316	.410	.726
20	Diamondbacks	399	411	.493	810	27,760	3,485	7,114	1,450	196	739	3,312	2,477	221	6,134	506	224	30,935	11,173	2,385	263	214	224	599	.256	.320	.402	.722
21	Mets	394	416	.486	810	27,608	3,299	6,809	1,428	128	679	3,150	2,590	266	6,273	475	167	30,920	10,530	2,235	270	186	223	578	.247	.315	.381	.697
22	Phillies	392	418	.484	810	27,711	3,252	6,908	1,307	162	706	3,100	2,240	281	5,903	482	134	30,712	10,657	2,175	306	174	196	566	.249	.310	.385	.695
23	White Sox	376	434	.464	810	27,659	3,282	6,962	1,256	123	804	3,145	2,168	308	5,992	448	216	30,491	10,876	2,183	151	205	133	613	.252	.311	.393	.704
24	Mariners	376	434	.464	810	27,467	3,089	6,573	1,252	120	780	2,939	2,304	194	6,460	443	185	30,307	10,405	2,152	169	173	139	534	.239	.301	.379	.680
25	Padres	374	436	.462	810	27,107	3,047	6,495	1,249	177	615	2,874	2,401	235	6,488	616	187	30,223	9,943	2,041	278	202	163	530	.240	.305	.367	.672