Since 2021, the Los Angeles Dodgers have the most wins by a team, with 444 wins.

Interpreted as:

teams with most MLB regular-season wins since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	444	249	.641	693	23,550	3,684	6,010	1,246	110	1,005	3,553	2,637	322	5,850	436	92	26,796	10,491	2,361	53	234	127	413	.255	.335	.445	.781
2	Braves	405	287	.585	692	23,470	3,409	5,942	1,196	75	1,048	3,276	2,191	272	6,083	376	106	26,151	10,432	2,319	49	169	84	455	.253	.322	.444	.766
3	Astros	402	289	.582	691	23,558	3,347	6,089	1,192	70	884	3,220	2,237	280	5,163	358	103	26,320	10,073	2,146	52	193	93	542	.258	.328	.428	.755
4	Yankees	393	299	.568	692	23,033	3,262	5,529	985	56	1,008	3,108	2,650	254	6,024	386	117	26,171	9,650	2,049	48	186	103	557	.240	.323	.419	.742
5	Brewers	387	306	.558	693	23,124	3,161	5,515	1,071	88	792	3,014	2,501	291	6,169	582	135	26,139	9,138	1,951	68	155	91	484	.238	.319	.395	.714
6	Rays	385	307	.556	692	23,294	3,161	5,663	1,173	103	777	3,001	2,227	311	6,219	572	185	26,018	9,373	2,053	29	157	62	396	.243	.316	.402	.718
7	Phillies	380	312	.549	692	23,437	3,271	5,908	1,159	113	866	3,140	2,266	264	5,965	511	111	26,229	9,891	2,138	83	179	101	467	.252	.323	.422	.745
8	Mariners	377	314	.546	691	23,015	3,027	5,322	1,028	57	850	2,904	2,421	412	6,498	450	122	26,054	9,014	1,935	44	162	55	439	.231	.314	.392	.705
9	Giants	373	320	.538	693	23,226	3,105	5,554	1,122	91	824	2,971	2,367	304	6,256	280	78	26,153	9,330	2,037	75	181	96	481	.239	.315	.402	.717
10	Mets	370	323	.534	693	23,071	3,100	5,674	1,080	92	821	2,965	2,207	430	5,664	373	90	25,948	9,401	1,993	84	156	78	494	.246	.321	.407	.729
11	Padres	370	321	.535	691	23,208	3,143	5,771	1,145	77	767	3,001	2,412	251	5,334	450	130	26,165	9,371	1,989	113	181	105	512	.249	.324	.404	.728
12	Blue Jays	367	325	.530	692	23,488	3,213	6,022	1,242	71	846	3,086	2,194	269	5,322	347	114	26,155	9,944	2,159	44	160	66	535	.256	.325	.423	.748
13	Guardians	365	326	.528	691	23,134	2,965	5,650	1,117	103	689	2,809	1,985	304	5,193	562	137	25,695	9,040	1,909	79	193	130	464	.244	.310	.391	.701
14	Cardinals	362	331	.522	693	23,405	3,091	5,835	1,162	77	812	2,962	2,223	311	5,559	408	115	26,205	9,587	2,051	79	187	78	460	.249	.320	.410	.730
15	Red Sox	351	343	.506	694	23,777	3,310	6,109	1,414	91	807	3,158	2,125	288	6,127	395	122	26,410	10,126	2,312	43	177	100	480	.257	.323	.426	.749
16	Twins	345	348	.498	693	23,378	3,130	5,711	1,186	87	864	2,981	2,239	350	6,084	268	82	26,182	9,663	2,137	39	176	59	517	.244	.317	.413	.731
17	Orioles	342	349	.495	691	23,322	3,085	5,691	1,169	107	833	2,960	2,052	278	5,954	385	112	25,884	9,573	2,109	54	178	53	419	.244	.311	.410	.721
18	Cubs	337	356	.486	693	23,238	3,174	5,660	1,091	127	799	3,026	2,295	337	6,158	531	148	26,139	9,402	2,017	96	173	66	467	.244	.318	.405	.723
19	Tigers	337	356	.486	693	23,214	2,846	5,507	1,024	147	675	2,733	2,010	222	6,259	315	99	25,673	8,850	1,846	48	179	42	446	.237	.302	.381	.683
20	Reds	326	368	.470	694	23,174	3,129	5,590	1,131	100	799	2,989	2,223	394	6,224	541	164	26,036	9,318	2,030	87	158	47	468	.241	.316	.402	.718
21	Diamondbacks	323	370	.466	693	23,314	3,243	5,726	1,208	143	755	3,078	2,353	276	5,655	471	112	26,297	9,485	2,106	141	213	72	462	.246	.319	.407	.726
22	Rangers	320	374	.461	694	23,435	3,054	5,673	1,052	81	822	2,920	2,093	229	5,883	446	124	25,958	9,353	1,955	44	157	61	420	.242	.309	.399	.708
23	Royals	306	388	.441	694	23,251	2,894	5,716	1,097	155	664	2,777	1,838	240	5,424	564	159	25,649	9,115	1,916	97	223	56	414	.246	.305	.392	.697
24	Angels	304	387	.440	691	23,118	2,884	5,475	1,014	100	835	2,754	2,017	296	6,299	380	140	25,649	9,194	1,949	78	140	99	462	.237	.305	.398	.702
25	Marlins	299	392	.433	691	23,233	2,694	5,619	1,044	95	658	2,566	1,853	252	6,056	478	136	25,583	8,827	1,797	89	156	75	513	.242	.303	.380	.683