Since 2021, the Los Angeles Dodgers have the most wins by a team, with 471 wins.

Interpreted as:

teams with most MLB regular-season wins since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	471	269	.636	740	25,159	3,926	6,410	1,320	116	1,072	3,786	2,804	342	6,229	453	97	28,606	11,178	2,508	53	248	138	442	.255	.335	.444	.779
2	Astros	434	304	.588	738	25,164	3,568	6,524	1,260	75	952	3,431	2,358	305	5,514	383	114	28,087	10,790	2,287	53	207	96	583	.259	.328	.429	.756
3	Braves	421	315	.572	736	24,961	3,587	6,308	1,256	78	1,094	3,449	2,350	285	6,472	390	110	27,828	11,002	2,428	51	181	90	487	.253	.322	.441	.763
4	Brewers	417	322	.564	739	24,685	3,397	5,923	1,143	93	843	3,239	2,665	309	6,529	628	151	27,908	9,781	2,079	76	173	95	507	.240	.320	.396	.716
5	Yankees	416	322	.564	738	24,593	3,468	5,915	1,060	64	1,072	3,304	2,828	265	6,427	416	127	27,935	10,319	2,196	51	198	122	592	.241	.323	.420	.743
6	Rays	414	325	.560	739	24,891	3,419	6,098	1,252	109	839	3,245	2,364	330	6,594	638	203	27,793	10,085	2,200	39	169	70	427	.245	.317	.405	.722
7	Phillies	407	332	.551	739	25,022	3,475	6,308	1,234	119	918	3,334	2,410	283	6,338	548	120	27,993	10,534	2,271	89	189	105	491	.252	.323	.421	.744
8	Mariners	401	337	.543	738	24,649	3,223	5,737	1,098	59	910	3,095	2,554	437	6,909	486	132	27,865	9,683	2,067	51	174	67	470	.233	.314	.393	.707
9	Blue Jays	399	340	.540	739	25,085	3,458	6,443	1,314	74	903	3,319	2,363	287	5,605	366	120	27,963	10,614	2,291	57	171	78	570	.257	.326	.423	.749
10	Giants	397	343	.536	740	24,749	3,271	5,895	1,190	101	860	3,127	2,532	332	6,647	300	85	27,896	9,867	2,151	87	196	101	518	.238	.315	.399	.714
11	Mets	394	345	.533	739	24,603	3,295	6,042	1,142	94	887	3,158	2,355	462	6,032	409	95	27,678	10,033	2,123	88	170	87	530	.246	.321	.408	.729
12	Padres	391	347	.530	738	24,776	3,312	6,132	1,209	83	804	3,163	2,566	263	5,678	477	137	27,922	9,919	2,096	123	194	112	541	.247	.322	.400	.723
13	Cardinals	385	354	.521	739	24,950	3,283	6,205	1,226	80	860	3,147	2,347	338	5,919	424	120	27,917	10,171	2,166	84	198	82	488	.249	.319	.408	.727
14	Guardians	381	355	.518	736	24,613	3,104	5,972	1,186	108	726	2,944	2,114	316	5,578	594	148	27,332	9,552	2,020	85	204	138	490	.243	.308	.388	.696
15	Red Sox	376	364	.508	740	25,361	3,544	6,515	1,518	99	864	3,382	2,269	310	6,544	426	132	28,176	10,823	2,481	47	189	107	508	.257	.323	.427	.750
16	Orioles	367	370	.498	737	24,892	3,297	6,080	1,251	111	891	3,160	2,180	298	6,361	422	122	27,616	10,226	2,253	56	190	60	449	.244	.311	.411	.721
17	Cubs	365	373	.495	738	24,792	3,409	6,067	1,170	135	871	3,255	2,440	347	6,497	586	156	27,864	10,120	2,176	98	187	73	483	.245	.319	.408	.727
18	Tigers	365	375	.493	740	24,788	3,058	5,893	1,107	159	735	2,938	2,150	244	6,659	328	104	27,427	9,523	2,001	49	196	45	467	.238	.303	.384	.687
19	Twins	363	375	.492	738	24,899	3,319	6,074	1,251	90	924	3,165	2,372	378	6,468	289	90	27,875	10,277	2,265	41	185	61	547	.244	.317	.413	.730
20	Reds	350	389	.474	739	24,673	3,332	5,962	1,202	108	846	3,179	2,356	405	6,607	557	173	27,699	9,918	2,156	91	174	50	503	.242	.316	.402	.718
21	Diamondbacks	344	395	.465	739	24,883	3,480	6,118	1,273	156	827	3,310	2,500	300	6,034	495	121	28,064	10,184	2,256	150	231	75	489	.246	.319	.409	.729
22	Rangers	340	399	.460	739	24,975	3,241	6,025	1,121	85	865	3,096	2,243	250	6,266	493	134	27,687	9,911	2,071	47	172	70	443	.241	.308	.397	.705
23	Angels	330	408	.447	738	24,721	3,105	5,860	1,080	105	906	2,966	2,172	327	6,757	401	153	27,454	9,868	2,091	83	151	108	488	.237	.305	.399	.705
24	Royals	325	415	.439	740	24,795	3,050	6,096	1,177	161	701	2,931	1,939	262	5,738	594	174	27,336	9,698	2,039	108	232	62	440	.246	.305	.391	.696
25	Marlins	323	414	.438	737	24,809	2,887	6,025	1,123	104	698	2,753	1,982	261	6,400	509	149	27,316	9,450	1,925	96	168	77	544	.243	.304	.381	.685