Since 2021, the Los Angeles Dodgers have the most wins by a team, with 443 wins.

Interpreted as:

teams with most regular-season wins in MLB since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	443	248	.641	691	23,481	3,663	5,985	1,243	110	999	3,532	2,624	322	5,837	434	92	26,712	10,445	2,352	53	232	127	408	.255	.335	.445	.780
2	Braves	404	287	.585	691	23,438	3,405	5,935	1,196	75	1,046	3,272	2,186	272	6,074	376	105	26,114	10,419	2,317	49	169	84	454	.253	.322	.445	.767
3	Astros	401	288	.582	689	23,490	3,341	6,075	1,190	70	883	3,214	2,230	280	5,150	358	103	26,245	10,054	2,143	52	193	93	542	.259	.328	.428	.756
4	Yankees	392	299	.567	691	23,002	3,256	5,521	984	56	1,008	3,103	2,643	254	6,018	385	117	26,132	9,641	2,048	48	185	103	557	.240	.323	.419	.742
5	Brewers	387	305	.559	692	23,092	3,161	5,510	1,070	88	792	3,014	2,500	290	6,153	580	135	26,105	9,132	1,950	68	155	91	484	.239	.319	.395	.714
6	Rays	385	306	.557	691	23,259	3,157	5,655	1,172	103	777	2,997	2,227	311	6,210	571	185	25,983	9,364	2,052	29	157	62	396	.243	.316	.403	.718
7	Phillies	379	312	.548	691	23,406	3,263	5,899	1,158	112	866	3,132	2,258	263	5,961	510	111	26,188	9,879	2,136	83	178	101	466	.252	.323	.422	.745
8	Mariners	376	314	.545	690	22,980	3,022	5,312	1,028	57	847	2,899	2,418	412	6,489	450	122	26,016	8,995	1,932	44	162	55	437	.231	.313	.391	.705
9	Giants	372	320	.538	692	23,189	3,096	5,541	1,119	91	821	2,962	2,362	304	6,248	280	78	26,111	9,305	2,031	75	181	96	481	.239	.315	.401	.716
10	Mets	370	322	.535	692	23,039	3,098	5,669	1,077	92	821	2,963	2,201	430	5,653	372	90	25,910	9,393	1,990	84	156	78	494	.246	.321	.408	.729
11	Padres	370	320	.536	690	23,174	3,142	5,763	1,143	76	767	3,000	2,411	250	5,325	450	130	26,129	9,359	1,986	113	181	105	511	.249	.324	.404	.728
12	Blue Jays	367	324	.531	691	23,453	3,209	6,012	1,240	71	844	3,082	2,193	269	5,313	346	114	26,119	9,926	2,155	44	160	66	534	.256	.325	.423	.748
13	Guardians	365	325	.529	690	23,104	2,961	5,645	1,116	103	687	2,805	1,982	304	5,188	562	137	25,661	9,028	1,906	78	193	130	463	.244	.310	.391	.701
14	Cardinals	361	331	.522	692	23,366	3,081	5,822	1,157	77	812	2,953	2,222	311	5,551	408	115	26,164	9,569	2,046	79	186	78	459	.249	.320	.410	.730
15	Red Sox	351	342	.506	693	23,747	3,308	6,103	1,414	90	806	3,156	2,122	287	6,117	393	120	26,376	10,115	2,310	43	177	100	480	.257	.323	.426	.749
16	Twins	344	348	.497	692	23,343	3,127	5,703	1,185	87	864	2,979	2,238	349	6,079	268	82	26,145	9,654	2,136	39	176	59	516	.244	.318	.414	.731
17	Orioles	342	348	.496	690	23,283	3,082	5,677	1,166	107	833	2,957	2,048	277	5,939	383	110	25,839	9,556	2,106	54	177	53	419	.244	.310	.410	.721
18	Cubs	336	356	.486	692	23,199	3,161	5,645	1,087	126	798	3,014	2,293	335	6,150	530	148	26,094	9,378	2,011	96	171	66	467	.243	.318	.404	.722
19	Tigers	336	356	.486	692	23,178	2,841	5,497	1,023	147	672	2,728	2,006	221	6,249	315	99	25,632	8,830	1,842	48	179	42	446	.237	.302	.381	.683
20	Reds	325	368	.469	693	23,140	3,124	5,579	1,129	100	797	2,985	2,221	394	6,217	539	164	26,000	9,299	2,026	87	158	47	468	.241	.316	.402	.718
21	Diamondbacks	322	370	.465	692	23,281	3,235	5,714	1,203	143	755	3,070	2,350	275	5,653	467	112	26,258	9,468	2,101	141	211	72	461	.245	.319	.407	.726
22	Rangers	319	373	.461	692	23,375	3,050	5,665	1,051	81	820	2,916	2,092	228	5,867	444	124	25,896	9,338	1,952	44	157	61	420	.242	.309	.399	.708
23	Royals	306	387	.442	693	23,215	2,891	5,707	1,095	153	663	2,775	1,838	240	5,418	563	159	25,613	9,097	1,911	97	223	56	414	.246	.305	.392	.697
24	Angels	303	387	.439	690	23,082	2,878	5,465	1,011	100	834	2,748	2,014	294	6,284	380	140	25,608	9,178	1,945	78	140	99	461	.237	.304	.398	.702
25	Marlins	298	392	.432	690	23,199	2,685	5,606	1,041	95	658	2,557	1,846	251	6,047	478	136	25,539	8,811	1,794	89	154	75	513	.242	.303	.380	.682