Since 2021, the Los Angeles Dodgers have the most wins by a team, with 471 wins.

Interpreted as:

teams with most regular-season wins in MLB since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	471	268	.637	739	25,126	3,925	6,403	1,318	116	1,072	3,785	2,802	341	6,218	453	97	28,570	11,169	2,506	53	248	138	441	.255	.335	.445	.779
2	Astros	434	303	.589	737	25,132	3,563	6,518	1,260	75	949	3,426	2,356	305	5,510	383	114	28,053	10,775	2,284	53	207	96	583	.259	.328	.429	.757
3	Braves	421	315	.572	736	24,961	3,587	6,308	1,256	78	1,094	3,449	2,350	285	6,472	390	110	27,828	11,002	2,428	51	181	90	487	.253	.322	.441	.763
4	Yankees	416	322	.564	738	24,593	3,468	5,915	1,060	64	1,072	3,304	2,828	265	6,427	416	127	27,935	10,319	2,196	51	198	122	592	.241	.323	.420	.743
5	Brewers	416	322	.564	738	24,652	3,388	5,915	1,142	93	841	3,231	2,660	309	6,524	628	151	27,870	9,766	2,076	76	173	95	507	.240	.320	.396	.716
6	Rays	414	324	.561	738	24,861	3,418	6,093	1,251	109	839	3,244	2,362	330	6,588	638	203	27,761	10,079	2,199	39	169	70	426	.245	.317	.405	.722
7	Phillies	407	331	.551	738	24,991	3,474	6,302	1,233	119	918	3,334	2,407	283	6,333	548	120	27,958	10,527	2,270	88	189	105	490	.252	.323	.421	.744
8	Mariners	401	337	.543	738	24,649	3,223	5,737	1,098	59	910	3,095	2,554	437	6,909	486	132	27,865	9,683	2,067	51	174	67	470	.233	.314	.393	.707
9	Blue Jays	398	340	.539	738	25,051	3,450	6,435	1,313	74	900	3,311	2,358	287	5,601	365	120	27,923	10,596	2,287	56	171	78	570	.257	.326	.423	.749
10	Giants	396	343	.536	739	24,716	3,268	5,887	1,188	101	860	3,124	2,531	330	6,638	300	85	27,860	9,857	2,149	87	196	101	518	.238	.315	.399	.714
11	Mets	394	345	.533	739	24,603	3,295	6,042	1,142	94	887	3,158	2,355	462	6,032	409	95	27,678	10,033	2,123	88	170	87	530	.246	.321	.408	.729
12	Padres	391	346	.531	737	24,744	3,309	6,125	1,209	83	803	3,161	2,561	262	5,668	477	137	27,883	9,909	2,095	122	194	112	539	.248	.322	.400	.723
13	Cardinals	385	354	.521	739	24,950	3,283	6,204	1,226	80	860	3,147	2,347	338	5,919	424	120	27,917	10,170	2,166	84	198	82	488	.249	.319	.408	.727
14	Guardians	380	355	.517	735	24,578	3,097	5,962	1,182	108	724	2,937	2,112	316	5,573	593	148	27,293	9,532	2,014	83	204	138	490	.243	.308	.388	.696
15	Red Sox	375	364	.507	739	25,323	3,535	6,501	1,515	98	861	3,373	2,268	310	6,534	425	131	28,137	10,795	2,474	47	189	107	508	.257	.323	.426	.750
16	Orioles	367	370	.498	737	24,892	3,297	6,080	1,251	111	891	3,160	2,180	298	6,361	422	122	27,616	10,226	2,253	56	190	60	449	.244	.311	.411	.721
17	Cubs	365	373	.495	738	24,792	3,409	6,067	1,170	135	871	3,255	2,440	347	6,497	586	156	27,864	10,120	2,176	98	187	73	483	.245	.319	.408	.727
18	Tigers	364	375	.493	739	24,755	3,053	5,884	1,103	159	732	2,933	2,147	244	6,649	327	104	27,391	9,501	1,994	49	196	45	467	.238	.303	.384	.686
19	Twins	363	375	.492	738	24,899	3,319	6,074	1,251	90	924	3,165	2,372	378	6,468	289	90	27,875	10,277	2,265	41	185	61	547	.244	.317	.413	.730
20	Reds	350	388	.474	738	24,645	3,331	5,959	1,202	108	846	3,178	2,354	405	6,600	557	173	27,668	9,915	2,156	91	173	50	502	.242	.316	.402	.718
21	Diamondbacks	343	395	.465	738	24,850	3,474	6,109	1,270	155	826	3,304	2,494	299	6,025	494	120	28,022	10,167	2,251	148	231	75	489	.246	.319	.409	.729
22	Rangers	340	398	.461	738	24,940	3,236	6,017	1,120	85	864	3,091	2,240	249	6,258	493	134	27,648	9,899	2,069	47	172	70	441	.241	.308	.397	.705
23	Angels	329	408	.446	737	24,688	3,099	5,850	1,076	105	905	2,960	2,168	327	6,749	401	153	27,416	9,851	2,086	83	150	107	488	.237	.305	.399	.704
24	Royals	324	415	.438	739	24,761	3,041	6,084	1,175	160	697	2,922	1,938	261	5,733	594	174	27,299	9,670	2,032	108	231	62	439	.246	.305	.391	.695
25	Marlins	322	414	.438	736	24,773	2,882	6,015	1,120	104	697	2,748	1,981	259	6,393	508	149	27,276	9,434	1,921	96	167	77	543	.243	.304	.381	.685