Since 2000, the New York Yankees have the most wins by a team, with 2,311 wins.

Interpreted as:

teams with most regular-season wins since 2000

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,311	1,676	.580	3,989	136,279	20,314	35,670	6,737	494	5,437	19,461	14,770	1,597	29,253	2,442	770	154,356	59,706	12,668	593	1,117	770	3,220	.262	.338	.438	.777
2	Dodgers	2,267	1,724	.568	3,991	135,551	18,503	34,925	6,861	692	4,465	17,651	13,711	1,496	29,057	2,341	857	153,092	56,565	12,018	1,269	1,065	1,068	2,974	.258	.330	.417	.747
3	Cardinals	2,203	1,786	.552	3,989	135,596	18,735	35,561	6,989	594	4,385	17,833	13,256	1,618	28,311	1,922	823	152,981	56,893	11,968	1,391	1,120	1,106	3,113	.262	.333	.420	.752
4	Braves	2,174	1,814	.545	3,989	136,120	18,534	35,314	7,064	607	4,516	17,701	13,313	1,307	30,034	1,986	785	153,095	57,140	12,187	1,352	1,003	1,055	3,075	.259	.329	.420	.749
5	Red Sox	2,167	1,825	.543	3,992	138,701	20,349	37,309	8,295	643	4,701	19,382	14,058	1,459	29,475	2,093	697	155,903	60,993	13,639	489	1,196	962	3,175	.269	.340	.440	.780
6	Giants	2,077	1,912	.521	3,990	135,754	17,492	34,668	6,981	846	3,881	16,651	12,839	1,287	28,598	1,792	758	152,317	54,984	11,708	1,310	1,127	1,237	3,113	.255	.323	.405	.728
7	Guardians	2,071	1,917	.519	3,988	135,975	18,683	35,150	7,305	630	4,334	17,799	13,333	1,565	28,921	2,418	870	152,856	56,717	12,269	822	1,161	766	3,021	.259	.329	.417	.746
8	Athletics	2,052	1,937	.514	3,989	135,695	18,149	33,872	6,983	579	4,383	17,294	13,802	1,427	29,217	1,893	617	152,534	55,162	11,945	529	1,081	608	3,145	.250	.323	.407	.730
9	Angels	2,051	1,939	.514	3,990	136,124	18,346	35,354	6,753	654	4,306	17,465	12,112	1,427	27,741	2,675	1,054	151,591	56,333	11,713	816	1,112	874	3,072	.260	.324	.414	.738
10	Astros	2,051	1,937	.514	3,989	135,651	18,382	35,005	7,012	625	4,584	17,538	12,881	1,515	29,000	2,284	911	152,262	57,019	12,221	1,144	1,071	818	3,173	.258	.327	.420	.747
11	Phillies	2,044	1,946	.512	3,990	136,332	18,322	34,698	6,972	793	4,444	17,474	13,528	1,493	30,562	2,569	688	153,536	56,588	12,209	1,198	985	1,130	2,767	.255	.326	.415	.741
12	Twins	2,008	1,985	.503	3,993	136,900	18,457	35,612	7,215	766	4,116	17,510	12,758	1,380	29,035	2,086	862	152,834	56,707	12,097	690	1,106	752	3,114	.260	.327	.414	.741
13	Mets	2,004	1,986	.502	3,990	135,237	17,507	34,142	6,756	656	4,201	16,704	13,052	1,601	29,316	2,379	809	152,175	54,813	11,613	1,284	1,001	1,045	2,969	.252	.323	.405	.729
14	Mariners	1,998	1,992	.501	3,990	136,008	17,532	34,390	6,502	577	4,159	16,686	12,592	1,481	29,951	2,543	923	151,892	54,523	11,238	772	1,039	763	2,868	.253	.321	.401	.722
15	Blue Jays	1,998	1,991	.501	3,989	136,553	18,838	35,240	7,400	574	4,867	17,994	12,806	1,432	28,729	1,932	719	152,419	58,389	12,841	555	1,073	588	3,188	.258	.326	.428	.753
16	Cubs	1,994	1,996	.500	3,991	135,684	17,981	34,413	6,944	715	4,491	17,123	13,073	1,567	31,181	2,011	835	152,618	56,260	12,150	1,324	970	947	2,950	.254	.324	.415	.739
17	Brewers	1,981	2,011	.496	3,993	134,896	17,773	33,832	6,821	671	4,596	16,978	13,157	1,655	32,356	2,681	905	151,892	55,783	12,088	1,229	955	922	3,010	.251	.323	.414	.736
18	Rays	1,978	2,010	.496	3,988	135,461	17,756	34,217	6,875	778	4,231	16,908	12,936	1,571	31,222	3,004	1,103	151,692	55,341	11,884	654	1,070	637	2,740	.253	.323	.409	.731
19	Rangers	1,960	2,033	.491	3,993	137,113	19,421	35,794	7,082	659	4,937	18,501	12,414	1,453	29,749	2,422	871	152,817	59,005	12,678	727	1,110	681	2,876	.261	.327	.430	.757
20	Diamondbacks	1,945	2,047	.487	3,992	136,105	18,154	34,599	7,181	972	4,231	17,311	13,275	1,308	30,306	2,290	825	153,022	56,417	12,384	1,219	1,115	1,006	2,862	.254	.324	.415	.738
21	White Sox	1,925	2,067	.482	3,992	135,855	18,000	34,910	6,596	559	4,624	17,250	11,589	1,517	29,271	2,222	981	150,844	56,496	11,779	872	1,011	547	3,096	.257	.320	.416	.736
22	Padres	1,915	2,076	.480	3,991	134,683	16,848	33,340	6,463	722	3,834	16,015	13,221	1,238	30,824	2,478	881	151,367	52,749	11,019	1,185	1,040	856	2,886	.248	.318	.392	.710
23	Nationals	1,896	2,095	.475	3,991	134,854	17,342	34,380	6,988	659	3,983	16,490	12,792	1,436	29,396	2,468	955	151,564	54,635	11,630	1,463	1,019	1,028	3,051	.255	.324	.405	.729
24	Reds	1,882	2,111	.471	3,995	135,397	17,802	34,050	6,752	599	4,574	16,999	13,147	1,698	31,540	2,534	956	152,602	55,722	11,925	1,391	969	931	2,831	.251	.323	.412	.735
25	Tigers	1,870	2,117	.469	3,987	136,706	17,829	35,617	6,823	945	4,107	17,057	11,727	1,224	29,884	1,814	821	151,479	56,651	11,875	738	1,084	673	3,091	.261	.322	.414	.737