Since 2000, the New York Yankees have the most wins by a team, with 2,334 wins.

Interpreted as:

teams with most regular-season wins since 2000

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,334	1,693	.580	4,029	137,614	20,486	35,992	6,797	502	5,487	19,625	14,928	1,607	29,601	2,469	780	155,873	60,254	12,786	595	1,129	784	3,250	.262	.338	.438	.776
2	Dodgers	2,292	1,741	.568	4,033	136,997	18,742	35,298	6,931	698	4,530	17,881	13,870	1,513	29,391	2,356	862	154,729	57,215	12,159	1,269	1,080	1,079	3,005	.258	.330	.418	.748
3	Cardinals	2,226	1,804	.552	4,030	136,985	18,926	35,904	7,049	597	4,429	18,016	13,365	1,643	28,629	1,938	828	154,521	57,434	12,075	1,396	1,132	1,110	3,137	.262	.332	.419	.752
4	Braves	2,190	1,837	.544	4,028	137,439	18,698	35,640	7,116	609	4,556	17,860	13,462	1,317	30,371	1,999	790	154,587	57,642	12,281	1,354	1,015	1,060	3,104	.259	.329	.419	.748
5	Red Sox	2,186	1,846	.542	4,032	140,055	20,527	37,635	8,372	650	4,747	19,551	14,189	1,480	29,849	2,118	705	157,422	61,548	13,769	493	1,205	968	3,201	.269	.340	.439	.779
6	Giants	2,097	1,932	.520	4,030	137,035	17,632	34,954	7,031	855	3,914	16,782	12,991	1,309	28,920	1,811	765	153,796	55,437	11,800	1,322	1,139	1,240	3,147	.255	.323	.405	.728
7	Guardians	2,086	1,941	.518	4,027	137,251	18,810	35,429	7,363	635	4,367	17,922	13,448	1,576	29,259	2,448	878	154,271	57,163	12,365	827	1,169	772	3,048	.258	.329	.416	.745
8	Astros	2,079	1,951	.516	4,031	137,062	18,558	35,370	7,066	627	4,639	17,706	12,987	1,537	29,317	2,309	921	153,813	57,607	12,332	1,145	1,082	820	3,210	.258	.327	.420	.747
9	Angels	2,075	1,956	.515	4,031	137,518	18,547	35,692	6,813	658	4,372	17,657	12,238	1,455	28,138	2,693	1,066	153,152	56,937	11,843	820	1,121	880	3,096	.260	.324	.414	.738
10	Phillies	2,068	1,963	.513	4,031	137,717	18,506	35,047	7,041	798	4,487	17,650	13,656	1,512	30,883	2,601	695	155,082	57,145	12,326	1,202	995	1,133	2,789	.254	.326	.415	.741
11	Athletics	2,064	1,968	.512	4,032	137,137	18,309	34,210	7,047	582	4,430	17,449	13,956	1,440	29,599	1,920	622	154,151	55,711	12,059	531	1,087	611	3,185	.249	.323	.406	.729
12	Twins	2,024	2,009	.502	4,033	138,261	18,631	35,942	7,275	769	4,170	17,679	12,878	1,407	29,368	2,101	867	154,352	57,265	12,214	692	1,114	754	3,141	.260	.327	.414	.741
13	Mets	2,024	2,007	.502	4,031	136,610	17,670	34,466	6,814	658	4,258	16,866	13,189	1,626	29,654	2,411	814	153,725	55,370	11,730	1,286	1,014	1,053	3,000	.252	.323	.405	.729
14	Blue Jays	2,022	2,008	.502	4,030	137,944	19,035	35,603	7,464	577	4,915	18,181	12,945	1,449	28,974	1,949	724	153,986	58,966	12,956	564	1,084	596	3,222	.258	.326	.427	.753
15	Cubs	2,018	2,012	.501	4,031	137,075	18,190	34,778	7,017	722	4,552	17,327	13,193	1,577	31,487	2,061	842	154,154	56,895	12,291	1,326	983	953	2,966	.254	.324	.415	.739
16	Mariners	2,018	2,013	.501	4,031	137,454	17,711	34,759	6,560	579	4,210	16,860	12,714	1,504	30,315	2,577	932	153,499	55,107	11,349	778	1,049	774	2,898	.253	.321	.401	.722
17	Brewers	2,007	2,025	.498	4,033	136,252	17,977	34,188	6,884	675	4,638	17,172	13,299	1,670	32,677	2,724	920	153,429	56,336	12,197	1,237	971	926	3,029	.251	.323	.413	.736
18	Rays	2,006	2,024	.498	4,030	136,896	17,997	34,613	6,945	784	4,289	17,136	13,058	1,590	31,564	3,064	1,116	153,284	55,993	12,018	662	1,078	640	2,766	.253	.323	.409	.732
19	Rangers	1,978	2,055	.490	4,033	138,464	19,575	36,091	7,141	663	4,974	18,646	12,540	1,471	30,093	2,460	880	154,329	59,480	12,778	730	1,124	689	2,894	.261	.326	.430	.756
20	Diamondbacks	1,963	2,068	.487	4,031	137,448	18,364	34,944	7,241	983	4,290	17,517	13,396	1,328	30,615	2,316	833	154,529	57,021	12,514	1,224	1,133	1,009	2,885	.254	.324	.415	.739
21	White Sox	1,939	2,093	.481	4,032	137,175	18,138	35,213	6,664	565	4,657	17,378	11,720	1,525	29,620	2,245	991	152,323	56,978	11,886	879	1,024	550	3,122	.257	.320	.415	.735
22	Padres	1,933	2,099	.479	4,032	136,050	16,997	33,654	6,525	728	3,868	16,158	13,346	1,249	31,117	2,501	888	152,890	53,239	11,121	1,194	1,051	860	2,912	.247	.318	.391	.709
23	Nationals	1,913	2,117	.475	4,030	136,182	17,525	34,714	7,064	664	4,025	16,668	12,901	1,455	29,677	2,496	973	153,039	55,181	11,753	1,471	1,030	1,038	3,075	.255	.324	.405	.729
24	Reds	1,905	2,127	.472	4,034	136,700	17,981	34,385	6,816	606	4,618	17,167	13,266	1,706	31,870	2,551	965	154,049	56,267	12,040	1,394	983	934	2,859	.252	.323	.412	.735
25	Tigers	1,894	2,134	.470	4,028	138,076	18,009	35,959	6,898	957	4,157	17,233	11,845	1,244	30,232	1,825	825	153,004	57,242	12,012	739	1,100	676	3,110	.260	.322	.415	.737