Since 2021, the Colorado Rockies have lost the most games by a team, with 439 losses.

Interpreted as:

teams with the most regular-season losses since 2021

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	439	274	.616	713	.384	24,048	3,049	5,913	1,241	145	730	2,925	2,021	250	6,480	313	115	26,589	9,634	2,116	95	175	67	532	.246	.309	.401	.710
2	Athletics	426	291	.594	717	.406	23,817	2,833	5,485	1,102	82	785	2,702	2,193	310	6,306	451	108	26,578	9,106	1,969	90	168	52	501	.230	.302	.382	.684
3	Nationals	422	292	.591	714	.409	23,899	2,966	5,969	1,180	94	669	2,818	2,078	329	5,400	538	182	26,580	9,344	1,943	114	160	74	566	.250	.316	.391	.707
4	White Sox	416	299	.582	715	.418	24,027	2,867	5,785	1,138	56	696	2,740	1,973	259	6,049	339	99	26,491	9,123	1,890	84	148	48	542	.241	.304	.380	.683
5	Pirates	414	303	.577	717	.423	23,827	2,782	5,545	1,071	125	650	2,645	2,279	248	6,398	437	140	26,622	8,816	1,846	96	172	71	452	.233	.304	.370	.674
6	Marlins	407	307	.570	714	.430	24,012	2,776	5,811	1,086	97	675	2,646	1,916	256	6,217	492	145	26,438	9,116	1,858	94	160	75	532	.242	.303	.380	.683
7	Royals	400	315	.559	715	.441	23,972	2,965	5,915	1,130	157	679	2,847	1,879	248	5,563	578	168	26,432	9,396	1,966	103	230	59	427	.247	.305	.392	.697
8	Angels	396	318	.555	714	.445	23,898	2,999	5,665	1,051	102	871	2,864	2,080	308	6,510	392	146	26,514	9,533	2,024	81	147	101	473	.237	.305	.399	.704
9	Rangers	387	328	.541	715	.459	24,128	3,133	5,823	1,076	83	842	2,996	2,150	235	6,074	470	130	26,721	9,591	2,001	45	163	63	427	.241	.308	.398	.705
10	Diamondbacks	383	333	.535	716	.465	24,103	3,359	5,928	1,241	150	792	3,192	2,428	286	5,835	484	116	27,181	9,845	2,183	145	219	75	478	.246	.320	.408	.728
11	Reds	378	339	.527	717	.473	23,938	3,227	5,783	1,169	104	825	3,083	2,297	398	6,422	550	171	26,888	9,635	2,098	90	165	50	484	.242	.316	.402	.719
12	Tigers	365	351	.510	716	.490	23,979	2,927	5,685	1,065	153	693	2,812	2,073	230	6,465	320	102	26,513	9,135	1,911	48	183	44	458	.237	.302	.381	.683
13	Cubs	364	352	.508	716	.492	24,046	3,293	5,876	1,138	131	829	3,142	2,371	340	6,338	564	153	27,035	9,763	2,098	97	181	71	477	.244	.319	.406	.725
14	Orioles	360	353	.505	713	.495	24,076	3,175	5,880	1,206	110	855	3,042	2,112	286	6,146	408	116	26,716	9,871	2,171	55	187	54	436	.244	.310	.410	.720
15	Twins	359	355	.503	714	.497	24,106	3,225	5,895	1,218	89	890	3,073	2,307	367	6,258	276	85	27,002	9,961	2,197	40	182	60	533	.245	.318	.413	.731
16	Red Sox	355	362	.495	717	.505	24,584	3,428	6,316	1,465	93	834	3,272	2,210	300	6,343	408	125	27,320	10,469	2,392	45	181	104	494	.257	.324	.426	.749
17	Cardinals	343	373	.479	716	.521	24,176	3,185	6,023	1,193	80	832	3,054	2,280	325	5,739	415	118	27,057	9,872	2,105	83	193	80	474	.249	.320	.408	.728
18	Guardians	339	375	.475	714	.525	23,898	3,050	5,833	1,153	106	708	2,891	2,053	314	5,394	581	142	26,545	9,322	1,967	81	199	134	480	.244	.310	.390	.700
19	Padres	333	381	.466	714	.534	23,980	3,223	5,942	1,175	81	785	3,077	2,477	256	5,506	468	134	27,019	9,634	2,041	120	186	106	524	.248	.323	.402	.724
20	Blue Jays	332	384	.464	716	.536	24,300	3,334	6,237	1,283	73	876	3,202	2,281	275	5,458	357	116	27,075	10,294	2,232	52	167	71	555	.257	.325	.424	.749
21	Mets	330	385	.462	715	.538	23,814	3,203	5,856	1,113	94	853	3,067	2,288	448	5,839	395	93	26,801	9,716	2,060	86	165	86	513	.246	.322	.408	.730
22	Giants	329	386	.460	715	.540	23,922	3,164	5,698	1,146	96	838	3,026	2,440	315	6,435	297	82	26,945	9,550	2,080	80	188	98	499	.238	.315	.399	.714
23	Mariners	329	386	.460	715	.540	23,852	3,112	5,526	1,057	59	878	2,988	2,489	421	6,718	470	128	26,973	9,335	1,994	46	165	57	454	.232	.313	.391	.705
24	Phillies	323	393	.451	716	.549	24,253	3,373	6,109	1,197	116	892	3,236	2,334	274	6,151	533	116	27,131	10,214	2,205	86	184	103	478	.252	.322	.421	.743
25	Brewers	315	402	.439	717	.561	23,929	3,267	5,708	1,104	90	817	3,116	2,591	300	6,367	610	141	27,054	9,443	2,011	73	161	93	493	.239	.319	.395	.713