The New York Yankees had the highest run differential by a team this season, with a differential of 366 runs.

Interpreted as:

What team goes up by 2 or more runs the most this regular season?

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	366	2025	71	1.000	71	0	2,494	560	753	153	8	166	544	335	35	601	80	22	2,898	1,420	327	1	33	23	38	.302	.388	.569	.957
2	Brewers	364	2025	69	1.000	69	0	2,387	513	719	126	9	98	476	270	36	482	84	22	2,739	1,157	233	19	27	6	50	.301	.377	.485	.862
3	Cubs	359	2025	67	1.000	67	0	2,383	511	727	139	21	146	498	261	27	478	81	13	2,710	1,346	306	5	34	8	24	.305	.375	.565	.940
4	Tigers	334	2025	66	1.000	66	0	2,285	471	694	118	19	121	449	222	35	535	30	8	2,574	1,213	258	4	28	4	40	.304	.370	.531	.901
5	Phillies	329	2025	70	1.000	70	0	2,462	507	759	154	16	142	493	271	31	538	64	14	2,801	1,371	312	8	29	9	38	.308	.380	.557	.937
6	Dodgers	328	2025	68	1.000	68	0	2,372	504	700	138	12	136	482	275	29	519	37	13	2,713	1,270	286	5	32	18	38	.295	.371	.535	.906
7	Blue Jays	325	2025	67	1.000	67	0	2,340	496	751	155	8	107	477	240	33	395	43	13	2,655	1,243	270	17	25	10	43	.321	.388	.531	.919
8	Red Sox	321	2025	66	1.000	66	0	2,350	501	727	173	14	114	478	232	28	504	60	12	2,639	1,270	301	6	23	3	43	.309	.375	.540	.915
9	Rangers	298	2025	60	1.000	60	0	2,070	421	609	115	6	104	406	232	23	430	54	11	2,350	1,048	225	4	21	6	34	.294	.368	.506	.875
10	Athletics	291	2025	56	1.000	56	0	2,003	407	608	127	7	120	391	184	21	453	33	15	2,235	1,109	254	8	19	4	31	.304	.365	.554	.919
11	Mariners	285	2025	59	1.000	59	0	2,080	442	613	105	5	139	424	241	33	475	67	14	2,383	1,145	249	8	21	11	38	.295	.373	.550	.924
12	Mets	284	2025	60	1.000	60	0	2,091	447	637	124	8	128	436	213	37	441	68	9	2,368	1,161	260	6	21	10	43	.305	.376	.555	.931
13	Astros	279	2025	60	1.000	60	0	2,116	413	638	121	8	101	397	205	38	429	38	11	2,385	1,078	230	7	19	4	38	.302	.370	.509	.880
14	Padres	277	2025	60	1.000	60	0	2,068	412	631	116	7	82	390	240	25	399	49	9	2,375	1,007	205	20	22	5	35	.305	.380	.487	.867
15	Reds	274	2025	61	1.000	61	0	2,080	423	609	108	9	100	398	243	28	495	43	14	2,382	1,035	217	4	27	6	43	.293	.370	.498	.868
16	Rays	264	2025	55	1.000	55	0	1,969	411	619	114	9	96	389	173	19	443	82	20	2,189	1,039	219	8	20	3	33	.314	.372	.528	.900
17	Braves	261	2025	55	1.000	55	0	1,904	386	561	104	7	87	374	241	20	421	32	11	2,189	940	198	5	19	4	37	.295	.376	.494	.870
18	Diamondbacks	251	2025	59	1.000	59	0	1,997	401	576	121	15	107	393	220	32	452	63	13	2,298	1,048	243	18	31	8	33	.288	.363	.525	.888
19	Twins	247	2025	55	1.000	55	0	1,901	367	547	109	9	97	347	210	39	423	46	15	2,166	965	215	4	12	5	31	.288	.368	.508	.876
20	Royals	245	2025	58	1.000	58	0	2,034	399	623	153	6	94	391	186	28	354	63	12	2,285	1,070	253	15	22	7	33	.306	.369	.526	.895
21	Orioles	243	2025	48	1.000	48	0	1,680	349	506	103	7	87	333	174	26	378	42	12	1,906	884	197	2	24	7	33	.301	.371	.526	.897
22	Giants	240	2025	53	1.000	53	0	1,822	373	517	98	12	89	356	209	24	445	22	12	2,088	906	199	7	26	6	31	.284	.360	.497	.858
23	Guardians	230	2025	62	1.000	62	0	2,090	367	565	133	11	83	352	210	22	501	60	9	2,367	969	227	17	28	14	33	.270	.339	.464	.803
24	Cardinals	229	2025	52	1.000	52	0	1,790	351	531	117	4	74	331	184	28	392	35	12	2,034	878	195	11	21	8	32	.297	.367	.491	.858
25	White Sox	219	2025	45	1.000	45	0	1,586	340	477	103	3	79	331	173	16	339	35	7	1,798	823	185	7	16	1	17	.301	.372	.519	.891