The Philadelphia Phillies have the lowest run differential by a team, with a differential of -5,706 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,706	21,719	.474	10,249	11,355	743,147	96,447	193,508	33,451	6,681	14,217	86,666	67,820	5,423	105,525	14,981	2,919	831,328	282,972	54,349	11,919	3,019	3,742	9,875	.260	.326	.381	.706
2	Orioles	-5,431	19,384	.475	9,150	10,124	658,425	83,695	169,898	29,367	4,914	14,460	77,381	63,354	4,484	98,550	10,573	2,786	739,905	252,473	48,741	10,532	3,110	2,578	10,863	.258	.326	.383	.709
3	Twins	-3,239	19,394	.482	9,295	9,990	661,598	85,273	173,492	29,790	6,335	12,045	78,511	62,432	5,176	94,675	12,024	3,083	742,566	252,087	48,170	10,190	3,170	2,664	10,990	.262	.329	.381	.710
4	Athletics	-3,130	19,348	.486	9,358	9,903	655,826	85,393	168,808	29,246	5,334	14,171	78,695	64,601	4,740	99,255	12,125	3,209	738,957	251,235	48,751	10,683	3,107	2,272	10,639	.257	.327	.383	.710
5	Padres	-2,846	8,916	.467	4,166	4,748	301,408	36,141	75,152	13,299	1,764	7,278	33,985	28,690	2,130	59,641	6,021	2,608	338,200	113,813	22,341	3,717	2,255	2,688	6,515	.249	.317	.378	.694
6	Marlins	-2,247	5,081	.459	2,331	2,750	172,721	21,374	44,006	8,372	984	4,625	20,267	15,614	1,837	38,448	3,266	1,302	193,177	68,221	13,981	1,722	1,283	1,203	3,816	.255	.321	.395	.716
7	Royals	-2,185	8,905	.476	4,242	4,661	304,587	38,910	79,985	14,947	2,294	7,018	36,724	26,045	2,467	52,284	7,106	2,904	338,150	120,574	24,259	2,375	2,676	1,870	6,794	.263	.323	.396	.719
8	Rangers	-2,055	10,198	.476	4,854	5,338	348,113	45,875	89,766	16,002	1,893	10,223	43,347	32,967	2,708	65,373	5,965	2,853	389,590	140,223	28,118	2,964	2,838	2,254	7,805	.258	.324	.403	.727
9	Rockies	-1,951	5,091	.459	2,335	2,756	174,832	25,150	47,206	9,324	1,318	5,747	23,917	16,046	1,590	37,943	3,065	1,373	195,835	76,407	16,389	2,005	1,362	1,209	3,882	.270	.335	.437	.772
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Mariners	-1,661	7,621	.477	3,635	3,984	259,980	33,826	66,798	12,450	1,260	7,755	32,137	24,641	2,363	49,931	5,047	2,175	291,013	105,033	21,465	1,950	2,079	1,668	5,693	.257	.325	.404	.729
13	Nationals	-1,492	8,909	.482	4,295	4,610	301,298	37,315	76,437	14,753	1,792	7,621	35,073	28,312	2,641	57,339	6,558	2,784	338,420	117,637	24,166	3,880	2,289	2,883	6,520	.254	.321	.390	.711
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
16	Brewers	-793	8,915	.488	4,347	4,564	302,594	39,621	77,465	14,436	1,759	8,730	37,538	29,126	2,720	59,130	6,011	2,738	340,029	121,609	24,925	3,167	2,422	2,160	6,621	.256	.324	.402	.726
17	Mets	-749	10,044	.484	4,861	5,175	339,814	41,454	84,908	15,169	1,819	8,617	39,039	32,504	2,880	65,144	5,910	2,738	381,813	129,566	25,605	3,989	2,626	3,145	7,482	.250	.318	.381	.700
18	Angels	-720	10,209	.495	5,054	5,152	346,360	44,176	88,600	15,316	1,812	9,249	41,569	32,378	2,837	62,964	6,058	3,106	387,892	135,287	26,377	3,540	2,777	2,485	7,890	.256	.322	.391	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-412	4,341	.491	2,130	2,211	147,581	19,311	37,451	7,465	851	4,527	18,369	14,039	1,686	33,611	3,246	1,235	165,209	60,199	12,843	742	1,161	688	3,037	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315