The Philadelphia Phillies have the lowest run differential by a team, with a differential of -5,702 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,702	21,729	.474	10,254	11,360	743,481	96,483	193,587	33,467	6,682	14,225	86,701	67,846	5,428	105,605	14,985	2,920	831,695	283,093	54,374	11,919	3,021	3,742	9,881	.260	.326	.381	.706
2	Orioles	-5,445	19,394	.475	9,154	10,130	658,750	83,731	169,963	29,376	4,914	14,471	77,417	63,380	4,491	98,639	10,577	2,788	740,265	252,580	48,761	10,533	3,111	2,580	10,867	.258	.326	.383	.709
3	Twins	-3,255	19,404	.482	9,298	9,997	661,936	85,325	173,577	29,807	6,335	12,064	78,562	62,467	5,181	94,747	12,025	3,084	742,945	252,246	48,206	10,190	3,171	2,665	10,994	.262	.329	.381	.710
4	Athletics	-3,156	19,358	.486	9,362	9,909	656,152	85,423	168,881	29,252	5,335	14,182	78,723	64,629	4,743	99,339	12,129	3,211	739,315	251,349	48,769	10,683	3,108	2,272	10,651	.257	.327	.383	.710
5	Padres	-2,848	8,926	.467	4,171	4,753	301,733	36,182	75,232	13,314	1,765	7,287	34,025	28,721	2,134	59,706	6,024	2,610	338,565	113,937	22,366	3,718	2,259	2,689	6,524	.249	.317	.378	.694
6	Marlins	-2,237	5,091	.459	2,337	2,754	173,064	21,422	44,098	8,391	987	4,632	20,314	15,648	1,840	38,524	3,272	1,303	193,562	68,359	14,010	1,724	1,286	1,203	3,821	.255	.321	.395	.716
7	Royals	-2,189	8,914	.476	4,246	4,666	304,877	38,936	80,039	14,962	2,295	7,028	36,750	26,069	2,468	52,340	7,112	2,907	338,467	120,675	24,285	2,377	2,676	1,872	6,798	.263	.323	.396	.719
8	Rangers	-2,064	10,207	.476	4,858	5,343	348,416	45,905	89,832	16,016	1,895	10,227	43,374	32,992	2,713	65,443	5,972	2,854	389,927	140,319	28,138	2,964	2,842	2,254	7,810	.258	.324	.403	.727
9	Rockies	-1,961	5,101	.459	2,339	2,762	175,173	25,196	47,290	9,341	1,320	5,764	23,961	16,067	1,594	38,047	3,076	1,376	196,204	76,563	16,425	2,006	1,364	1,209	3,891	.270	.334	.437	.772
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Mariners	-1,648	7,631	.477	3,640	3,989	260,327	33,883	66,890	12,467	1,260	7,770	32,192	24,666	2,370	50,022	5,054	2,177	291,398	105,187	21,497	1,951	2,084	1,669	5,699	.257	.325	.404	.729
13	Nationals	-1,500	8,919	.482	4,298	4,617	301,643	37,362	76,523	14,768	1,792	7,638	35,119	28,341	2,642	57,412	6,568	2,789	338,805	117,789	24,198	3,885	2,294	2,884	6,523	.254	.321	.390	.711
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
16	Brewers	-766	8,923	.488	4,353	4,566	302,881	39,684	77,559	14,454	1,759	8,740	37,598	29,156	2,722	59,184	6,019	2,744	340,356	121,751	24,953	3,168	2,429	2,162	6,626	.256	.325	.402	.727
17	Mets	-764	10,054	.484	4,864	5,182	340,147	41,490	84,985	15,178	1,819	8,633	39,075	32,524	2,881	65,234	5,913	2,739	382,171	129,700	25,630	3,989	2,630	3,145	7,485	.250	.318	.381	.700
18	Angels	-704	10,219	.495	5,061	5,155	346,703	44,222	88,679	15,326	1,813	9,267	41,615	32,413	2,847	63,070	6,062	3,110	388,282	135,432	26,406	3,541	2,778	2,488	7,892	.256	.322	.391	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
24	Rays	-393	4,351	.491	2,137	2,214	147,930	19,369	37,562	7,483	855	4,539	18,423	14,066	1,691	33,694	3,254	1,237	165,594	60,372	12,877	745	1,162	688	3,046	.254	.323	.408	.732
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315