The Washington Nationals had the lowest run differential by a team in 2009, with a differential of -164 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Nationals	-164	2009	162	.364	59	103	5,493	710	1,416	271	38	156	685	617	56	1,208	73	40	6,272	2,231	465	64	42	39	133	.258	.337	.406	.743
2	Royals	-156	2009	162	.401	65	97	5,532	686	1,432	276	51	144	657	457	42	1,091	88	29	6,101	2,242	471	38	32	20	135	.259	.318	.405	.724
3	Orioles	-135	2009	162	.395	64	98	5,618	741	1,508	307	19	160	708	517	39	1,013	76	37	6,233	2,333	486	13	46	25	131	.268	.332	.415	.747
4	Pirates	-132	2009	161	.385	62	99	5,417	636	1,364	289	34	125	612	499	46	1,142	90	32	6,058	2,096	448	60	36	44	124	.252	.318	.387	.705
5	Padres	-131	2009	162	.463	75	87	5,425	638	1,315	265	31	141	605	586	57	1,182	82	29	6,178	2,065	437	74	36	52	131	.242	.321	.381	.701
6	Astros	-127	2009	162	.457	74	88	5,436	643	1,415	270	32	142	616	448	43	990	113	44	6,038	2,175	444	66	45	37	153	.260	.319	.400	.719
7	Indians	-92	2009	162	.401	65	97	5,568	773	1,468	314	28	161	730	582	81	1,211	84	31	6,320	2,321	503	39	50	20	140	.264	.339	.417	.756
8	Mets	-86	2009	162	.432	70	92	5,453	671	1,472	295	49	95	631	526	36	928	122	44	6,158	2,150	439	88	55	49	144	.270	.335	.394	.729
9	Diamondbacks	-62	2009	162	.432	70	92	5,565	720	1,408	307	45	173	686	571	37	1,298	102	40	6,268	2,324	525	54	41	47	93	.253	.324	.418	.742
10	Mariners	-52	2009	162	.525	85	77	5,543	640	1,430	280	19	160	613	421	49	1,093	89	33	6,113	2,228	459	56	44	39	124	.258	.314	.402	.716
11	Reds	-50	2009	162	.481	78	84	5,462	673	1,349	280	25	158	637	531	53	1,129	96	40	6,187	2,153	463	100	41	37	103	.247	.318	.394	.712
12	Brewers	-33	2009	162	.494	80	82	5,510	785	1,447	281	37	182	757	610	71	1,231	68	37	6,296	2,348	500	58	47	44	128	.263	.341	.426	.767
13	White Sox	-8	2009	162	.488	79	83	5,463	724	1,410	246	20	184	695	534	62	1,022	113	49	6,132	2,248	450	34	39	25	139	.258	.329	.411	.740
14	Tigers	-2	2009	163	.528	86	77	5,540	743	1,443	245	35	183	718	540	61	1,114	72	33	6,233	2,307	463	53	39	30	131	.260	.331	.416	.747
15	Athletics	-2	2009	162	.463	75	87	5,584	759	1,464	307	21	135	723	527	50	1,046	133	48	6,246	2,218	463	31	54	16	130	.262	.328	.397	.726
16	Marlins	6	2009	162	.537	87	75	5,572	772	1,493	296	25	159	727	568	63	1,226	75	35	6,312	2,316	480	70	39	46	110	.268	.340	.416	.756
17	Blue Jays	27	2009	162	.463	75	87	5,696	798	1,516	339	13	209	766	548	45	1,028	73	23	6,362	2,508	561	24	49	23	130	.266	.333	.440	.773
18	Cubs	35	2009	161	.516	83	78	5,486	707	1,398	293	29	161	678	592	59	1,185	56	34	6,244	2,232	483	65	42	44	134	.255	.332	.407	.738
19	Rangers	44	2009	162	.537	87	75	5,526	784	1,436	296	27	224	748	472	37	1,253	149	36	6,126	2,458	547	40	51	23	97	.260	.320	.445	.764
20	Giants	46	2009	162	.543	88	74	5,493	657	1,411	275	43	122	612	392	50	1,158	78	28	6,057	2,138	440	67	55	41	115	.257	.309	.389	.699
21	Rays	49	2009	162	.519	84	78	5,462	803	1,434	297	36	199	765	642	49	1,229	194	61	6,223	2,400	532	25	45	36	104	.263	.343	.439	.782
22	Twins	52	2009	163	.534	87	76	5,608	817	1,539	271	40	172	770	585	45	1,021	85	32	6,346	2,406	483	51	57	46	147	.274	.345	.429	.774
23	Rockies	89	2009	162	.568	92	70	5,398	804	1,408	300	50	190	760	660	47	1,277	106	55	6,241	2,378	540	76	60	40	111	.261	.343	.441	.784
24	Cardinals	90	2009	162	.562	91	71	5,465	730	1,436	294	29	160	694	528	61	1,041	75	31	6,165	2,268	483	68	43	73	127	.263	.332	.415	.747
25	Braves	94	2009	162	.531	86	76	5,539	735	1,459	300	20	149	700	602	52	1,064	58	26	6,335	2,246	469	95	47	54	142	.263	.339	.405	.744